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OPENSEQ.org
XDHA - Xanthine dehydrogenase molybdenum-binding subunit
UniProt: Q46799 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13049
Length: 752 (747)
Sequences: 2672
Seq/Len: 3.58
XDHA
Paralog alert: 0.62 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: XDHA XDHD YAGR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_V 118_V 5.46 1.00
50_L 117_L 4.897 1.00
25_C 54_L 4.649 1.00
171_Q 285_Q 4.552 1.00
107_D 110_T 4.202 1.00
34_I 37_G 4.028 1.00
167_D 289_N 3.984 1.00
486_V 527_L 3.944 1.00
288_V 368_A 3.924 1.00
173_H 283_D 3.762 1.00
289_N 293_T 3.678 1.00
50_L 110_T 3.66 1.00
46_Q 119_S 3.58 1.00
298_S 333_A 3.504 1.00
374_I 382_R 3.485 1.00
30_V 115_A 3.46 1.00
37_G 122_W 3.357 1.00
158_N 161_Q 3.203 1.00
167_D 290_R 3.182 1.00
38_Y 123_Q 3.146 1.00
36_H 125_L 3.115 1.00
161_Q 165_A 3.061 1.00
294_L 365_L 3.01 1.00
34_I 124_E 2.985 1.00
381_L 408_E 2.977 1.00
465_I 492_V 2.94 1.00
40_V 121_E 2.889 1.00
171_Q 283_D 2.804 1.00
300_D 335_S 2.715 1.00
106_R 110_T 2.664 1.00
285_Q 298_S 2.662 1.00
489_T 532_L 2.657 1.00
54_L 106_R 2.645 1.00
163_I 287_G 2.625 1.00
200_T 229_I 2.615 1.00
115_A 118_V 2.552 1.00
44_D 48_R 2.545 1.00
724_V 737_L 2.521 1.00
304_N 343_L 2.504 1.00
293_T 382_R 2.498 1.00
227_R 504_D 2.471 1.00
168_Y 288_V 2.423 1.00
378_E 382_R 2.409 1.00
41_S 121_E 2.408 1.00
368_A 379_I 2.393 1.00
201_I 215_V 2.383 1.00
27_A 263_V 2.363 1.00
625_R 690_E 2.353 1.00
528_R 532_L 2.351 1.00
106_R 259_I 2.35 1.00
198_R 506_D 2.326 1.00
415_E 418_K 2.325 1.00
105_A 111_A 2.318 1.00
374_I 379_I 2.316 1.00
721_R 737_L 2.304 1.00
572_S 575_D 2.192 1.00
27_A 102_I 2.172 1.00
286_M 364_M 2.163 1.00
734_T 741_R 2.161 1.00
132_E 281_T 2.144 1.00
483_S 499_V 2.085 1.00
166_A 287_G 2.072 1.00
378_E 381_L 2.068 1.00
168_Y 290_R 2.066 1.00
53_V 105_A 2.05 1.00
300_D 337_K 2.048 1.00
459_M 534_L 2.041 1.00
34_I 122_W 2.038 1.00
192_W 202_V 2.021 1.00
40_V 123_Q 1.998 1.00
215_V 226_V 1.997 1.00
163_I 285_Q 1.968 1.00
485_M 524_A 1.964 1.00
457_L 467_V 1.963 1.00
27_A 261_V 1.961 1.00
43_N 119_S 1.948 1.00
520_S 636_L 1.945 1.00
410_G 609_F 1.943 1.00
650_G 686_L 1.941 1.00
166_A 295_K 1.934 1.00
33_P 100_V 1.934 1.00
38_Y 91_R 1.931 1.00
613_T 624_N 1.93 1.00
649_M 689_L 1.93 1.00
286_M 368_A 1.928 1.00
110_T 114_A 1.901 1.00
54_L 259_I 1.868 1.00
17_D 262_K 1.862 1.00
188_T 264_S 1.859 1.00
44_D 56_I 1.85 0.99
133_A 136_A 1.849 0.99
200_T 227_R 1.829 0.99
284_G 364_M 1.814 0.99
130_T 133_A 1.812 0.99
183_H 239_N 1.803 0.99
489_T 703_Y 1.797 0.99
175_Q 734_T 1.797 0.99
608_T 626_I 1.787 0.99
654_G 681_P 1.785 0.99
535_K 539_I 1.78 0.99
738_T 741_R 1.776 0.99
39_A 42_I 1.77 0.99
464_T 496_D 1.749 0.99
168_Y 289_N 1.739 0.99
45_E 48_R 1.735 0.99
457_L 531_A 1.731 0.99
455_A 527_L 1.717 0.99
286_M 294_L 1.693 0.99
31_R 269_E 1.689 0.99
94_R 98_D 1.683 0.99
182_C 675_L 1.672 0.99
36_H 92_H 1.662 0.99
464_T 498_R 1.656 0.99
162_T 296_G 1.648 0.99
46_Q 49_S 1.646 0.99
289_N 295_K 1.644 0.99
58_T 88_L 1.637 0.98
155_S 333_A 1.63 0.98
366_D 722_N 1.625 0.98
21_M 24_M 1.617 0.98
36_H 126_P 1.611 0.98
38_Y 92_H 1.609 0.98
221_I 226_V 1.607 0.98
168_Y 368_A 1.581 0.98
159_V 162_T 1.578 0.98
632_S 635_I 1.573 0.98
641_A 693_F 1.573 0.98
47_A 118_V 1.565 0.98
362_E 380_R 1.562 0.98
634_H 695_E 1.556 0.98
169_Q 285_Q 1.547 0.98
168_Y 372_L 1.545 0.98
53_V 111_A 1.545 0.98
291_D 382_R 1.528 0.97
41_S 119_S 1.528 0.97
635_I 693_F 1.527 0.97
652_G 716_V 1.518 0.97
50_L 114_A 1.515 0.97
409_K 692_A 1.51 0.97
104_V 252_L 1.509 0.97
46_Q 117_L 1.508 0.97
635_I 641_A 1.5 0.97
460_N 466_N 1.494 0.97
39_A 122_W 1.487 0.97
222_P 225_C 1.48 0.97
60_E 91_R 1.471 0.96
626_I 649_M 1.464 0.96
414_F 609_F 1.455 0.96
13_A 232_F 1.447 0.96
29_Y 263_V 1.442 0.96
159_V 163_I 1.439 0.96
275_R 347_G 1.439 0.96
293_T 328_P 1.439 0.96
610_V 626_I 1.438 0.96
612_L 724_V 1.434 0.96
467_V 497_V 1.429 0.96
460_N 464_T 1.419 0.95
163_I 296_G 1.419 0.95
113_K 117_L 1.413 0.95
302_L 337_K 1.41 0.95
160_Q 333_A 1.405 0.95
198_R 225_C 1.402 0.95
349_M 651_M 1.402 0.95
487_A 497_V 1.4 0.95
641_A 708_L 1.398 0.95
484_Q 638_P 1.395 0.95
484_Q 637_N 1.394 0.95
614_V 621_V 1.394 0.95
386_R 404_P 1.39 0.95
493_P 496_D 1.39 0.95
406_C 607_C 1.39 0.95
161_Q 164_D 1.388 0.95
489_T 528_R 1.386 0.95
28_K 115_A 1.383 0.94
614_V 619_C 1.378 0.94
288_V 379_I 1.372 0.94
432_R 613_T 1.372 0.94
482_F 527_L 1.361 0.94
283_D 300_D 1.359 0.94
367_D 733_N 1.355 0.94
160_Q 164_D 1.353 0.94
413_I 690_E 1.344 0.93
549_S 552_N 1.339 0.93
52_G 114_A 1.335 0.93
131_P 302_L 1.332 0.93
16_T 188_T 1.329 0.93
163_I 169_Q 1.327 0.93
623_I 653_I 1.323 0.93
328_P 389_D 1.322 0.93
381_L 411_R 1.322 0.93
36_H 127_V 1.315 0.92
485_M 520_S 1.312 0.92
525_P 528_R 1.308 0.92
553_L 560_I 1.307 0.92
465_I 490_V 1.306 0.92
202_V 229_I 1.305 0.92
37_G 120_I 1.302 0.92
610_V 623_I 1.295 0.92
621_V 657_L 1.285 0.91
114_A 117_L 1.282 0.91
489_T 531_A 1.276 0.91
172_G 367_D 1.276 0.91
30_V 120_I 1.272 0.91
409_K 412_K 1.271 0.91
467_V 486_V 1.269 0.90
402_G 405_E 1.265 0.90
173_H 281_T 1.261 0.90
170_V 288_V 1.259 0.90
98_D 308_Y 1.252 0.90
151_Q 335_S 1.251 0.90
53_V 114_A 1.249 0.90
37_G 125_L 1.248 0.89
183_H 270_C 1.246 0.89
621_V 724_V 1.243 0.89
251_F 254_S 1.242 0.89
372_L 379_I 1.241 0.89
44_D 118_V 1.24 0.89
24_M 262_K 1.239 0.89
370_T 725_K 1.238 0.89
413_I 629_V 1.236 0.89
39_A 120_I 1.236 0.89
409_K 413_I 1.234 0.89
645_V 649_M 1.231 0.89
381_L 404_P 1.223 0.88
359_F 721_R 1.22 0.88
29_Y 102_I 1.218 0.88
486_V 489_T 1.213 0.88
662_I 672_N 1.21 0.87
458_L 591_S 1.202 0.87
737_L 741_R 1.201 0.87
411_R 417_E 1.2 0.87
3_V 483_S 1.199 0.87
28_K 111_A 1.197 0.87
377_V 411_R 1.194 0.86
533_L 592_A 1.194 0.86
17_D 264_S 1.194 0.86
191_A 201_I 1.192 0.86
529_S 533_L 1.191 0.86
737_L 742_L 1.186 0.86
481_V 520_S 1.18 0.86
168_Y 371_A 1.175 0.85
105_A 114_A 1.174 0.85
49_S 119_S 1.174 0.85
278_H 356_Q 1.174 0.85
48_R 55_A 1.17 0.85
191_A 253_T 1.169 0.85
104_V 261_V 1.166 0.85
663_I 670_V 1.164 0.85
411_R 416_W 1.163 0.84
627_L 690_E 1.162 0.84
199_I 221_I 1.161 0.84
539_I 555_L 1.16 0.84
384_A 404_P 1.157 0.84
619_C 742_L 1.157 0.84
409_K 629_V 1.157 0.84
104_V 257_G 1.154 0.84
24_M 190_L 1.153 0.84
233_V 474_I 1.152 0.84
496_D 574_K 1.151 0.84
151_Q 337_K 1.15 0.84
20_V 24_M 1.149 0.84
287_G 296_G 1.145 0.83
174_Y 733_N 1.144 0.83
216_G 226_V 1.143 0.83
288_V 372_L 1.142 0.83
282_I 360_A 1.141 0.83
165_A 289_N 1.133 0.82
42_I 58_T 1.131 0.82
559_H 570_L 1.13 0.82
175_Q 281_T 1.13 0.82
56_I 101_A 1.13 0.82
23_G 259_I 1.129 0.82
288_V 364_M 1.126 0.82
370_T 726_M 1.121 0.81
187_V 270_C 1.12 0.81
135_L 339_C 1.119 0.81
204_S 240_K 1.115 0.81
548_Q 552_N 1.114 0.81
539_I 553_L 1.113 0.81
298_S 335_S 1.107 0.80
547_H 552_N 1.107 0.80
408_E 412_K 1.106 0.80
204_S 233_V 1.104 0.80
38_Y 125_L 1.104 0.80
163_I 166_A 1.103 0.80
25_C 259_I 1.101 0.80
486_V 497_V 1.1 0.80
172_G 371_A 1.098 0.80
534_L 590_L 1.097 0.79
3_V 480_T 1.094 0.79
366_D 376_P 1.094 0.79
286_M 297_Y 1.094 0.79
254_S 257_G 1.092 0.79
50_L 113_K 1.092 0.79
181_H 239_N 1.092 0.79
279_A 304_N 1.092 0.79
101_A 120_I 1.092 0.79
54_L 110_T 1.09 0.79
531_A 534_L 1.087 0.79
167_D 291_D 1.086 0.78
325_Y 328_P 1.085 0.78
48_R 114_A 1.085 0.78
414_F 627_L 1.085 0.78
36_H 342_N 1.085 0.78
54_L 104_V 1.081 0.78
29_Y 99_A 1.081 0.78
159_V 298_S 1.079 0.78
527_L 531_A 1.073 0.77
206_Q 236_G 1.071 0.77
471_A 478_A 1.07 0.77
631_D 696_I 1.07 0.77
162_T 331_A 1.068 0.77
128_I 134_A 1.065 0.77
325_Y 329_R 1.062 0.76
486_V 531_A 1.061 0.76
366_D 380_R 1.058 0.76
365_L 379_I 1.057 0.76
540_A 550_A 1.055 0.76
480_T 484_Q 1.055 0.76
52_G 106_R 1.053 0.75
483_S 494_V 1.053 0.75
302_L 339_C 1.052 0.75
407_L 436_V 1.047 0.75
100_V 120_I 1.046 0.75
57_F 104_V 1.046 0.75
93_V 122_W 1.045 0.75
236_G 474_I 1.044 0.75
364_M 368_A 1.041 0.74
213_R 223_W 1.04 0.74
28_K 108_E 1.039 0.74
101_A 118_V 1.037 0.74
92_H 144_N 1.033 0.73
653_I 686_L 1.032 0.73
30_V 101_A 1.031 0.73
456_R 468_Q 1.03 0.73
44_D 47_A 1.028 0.73
430_L 613_T 1.026 0.73
621_V 742_L 1.025 0.73
192_W 200_T 1.024 0.72
182_C 680_M 1.022 0.72
165_A 295_K 1.021 0.72
529_S 532_L 1.021 0.72
404_P 408_E 1.021 0.72
496_D 558_G 1.019 0.72
227_R 506_D 1.019 0.72
742_L 745_E 1.018 0.72
39_A 100_V 1.017 0.72
174_Y 367_D 1.016 0.72
43_N 47_A 1.014 0.71
532_L 536_E 1.011 0.71
108_E 112_E 1.011 0.71
28_K 112_E 1.005 0.70
180_Q 661_M 1.003 0.70
170_V 371_A 1.002 0.70
732_I 737_L 1.002 0.70
468_Q 500_I 1.002 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rm6A20.96811000.08Contact Map0.806
1t3qB20.9881000.09Contact Map0.826
1ffvB20.98011000.096Contact Map0.786
1n62B20.98141000.099Contact Map0.812
2w3sB40.96281000.109Contact Map0.783
3uncA20.93621000.119Contact Map0.801
3zyvA40.93221000.13Contact Map0.717
3nvzC20.95351000.131Contact Map0.786
1vlbA10.94151000.132Contact Map0.788
1dgjA10.93881000.136Contact Map0.752
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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