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OPENSEQ.org
YAGR - Putative xanthine dehydrogenase YagR molybdenum-binding subunit
UniProt: P77489 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13557
Length: 732 (711)
Sequences: 2655
Seq/Len: 3.73
YAGR
Paralog alert: 0.62 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: XDHA XDHD YAGR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_V 130_V 5.06 1.00
74_A 129_L 4.894 1.00
49_A 78_L 4.527 1.00
177_D 290_R 4.518 1.00
119_T 122_Q 4.226 1.00
58_I 61_G 3.843 1.00
173_A 294_D 3.804 1.00
179_T 288_H 3.782 1.00
70_A 131_Q 3.645 1.00
480_A 519_V 3.585 1.00
293_A 368_L 3.572 1.00
294_D 298_K 3.541 1.00
74_A 122_Q 3.487 1.00
303_S 333_H 3.428 1.00
374_I 382_L 3.397 1.00
62_R 135_R 3.392 1.00
167_G 171_S 3.338 1.00
61_G 134_Y 3.282 1.00
459_V 486_V 3.268 1.00
173_A 295_Q 3.176 1.00
164_D 167_G 3.174 1.00
64_T 133_H 3.171 1.00
54_V 127_A 3.149 1.00
381_I 406_R 3.1 1.00
413_G 416_Q 3.089 1.00
177_D 288_H 2.943 1.00
305_E 335_G 2.814 1.00
299_I 365_I 2.767 1.00
483_M 524_M 2.749 1.00
118_E 122_Q 2.734 1.00
78_L 118_E 2.684 1.00
65_A 133_H 2.605 1.00
68_T 72_Q 2.538 1.00
290_R 303_S 2.536 1.00
298_K 382_L 2.53 1.00
169_F 292_G 2.527 1.00
378_E 382_L 2.475 1.00
205_T 234_I 2.46 1.00
118_E 264_R 2.439 1.00
307_W 343_L 2.401 1.00
706_V 719_I 2.359 1.00
116_V 258_A 2.358 1.00
606_R 671_E 2.324 1.00
58_I 136_R 2.318 1.00
520_Y 524_M 2.313 1.00
374_I 379_F 2.309 1.00
117_A 123_A 2.27 1.00
368_L 379_F 2.258 1.00
451_V 461_V 2.248 1.00
232_R 497_D 2.245 1.00
127_A 130_V 2.224 1.00
174_V 293_A 2.22 1.00
51_G 114_L 2.199 1.00
716_D 723_K 2.174 1.00
378_E 381_I 2.152 1.00
631_T 667_I 2.135 1.00
203_K 499_S 2.131 1.00
703_A 719_I 2.124 1.00
453_L 526_L 2.111 1.00
172_A 292_G 2.106 1.00
51_G 268_V 2.076 1.00
206_L 220_L 2.036 1.00
67_D 131_Q 2.005 1.00
62_R 103_P 2.003 1.00
63_L 66_L 1.995 1.00
64_T 135_R 1.988 1.00
291_I 364_A 1.969 1.00
60_K 137_N 1.964 1.00
305_E 337_R 1.963 1.00
77_V 117_A 1.961 1.00
198_V 207_W 1.957 1.00
58_I 134_Y 1.955 1.00
172_A 300_T 1.946 1.00
556_T 559_E 1.921 1.00
22_H 488_L 1.92 1.00
477_A 493_V 1.905 1.00
174_V 295_Q 1.893 1.00
116_V 262_V 1.888 1.00
479_T 516_T 1.857 1.00
78_L 264_R 1.856 1.00
51_G 266_V 1.854 1.00
594_G 605_R 1.852 1.00
205_T 232_R 1.846 1.00
630_M 670_Q 1.845 1.00
194_A 269_M 1.841 1.00
298_K 328_A 1.84 1.00
328_A 389_P 1.828 0.99
57_A 112_I 1.819 0.99
122_Q 126_A 1.804 0.99
483_M 685_M 1.804 0.99
148_Q 151_N 1.797 0.99
512_A 617_L 1.796 0.99
527_R 531_A 1.795 0.99
189_A 244_G 1.79 0.99
289_L 364_A 1.788 0.99
39_Y 267_K 1.788 0.99
69_D 72_Q 1.787 0.99
68_T 80_V 1.783 0.99
291_I 368_L 1.782 0.99
169_F 290_R 1.767 0.99
458_T 490_Q 1.742 0.99
220_L 231_V 1.742 0.99
547_K 554_S 1.736 0.99
294_D 300_T 1.725 0.99
60_K 104_T 1.719 0.99
408_G 590_F 1.716 0.99
451_V 523_C 1.708 0.99
62_R 104_T 1.707 0.99
174_V 294_D 1.702 0.99
70_A 73_K 1.7 0.99
181_T 716_D 1.669 0.99
82_T 100_L 1.666 0.99
635_G 662_P 1.656 0.99
167_G 170_T 1.632 0.99
70_A 129_L 1.614 0.98
71_A 130_V 1.613 0.98
291_I 299_I 1.607 0.98
589_H 607_M 1.606 0.98
175_K 290_R 1.597 0.98
168_A 301_A 1.595 0.98
407_T 673_I 1.591 0.98
720_T 723_K 1.59 0.98
45_A 48_A 1.581 0.98
145_D 148_Q 1.57 0.98
412_F 590_F 1.567 0.98
63_L 134_Y 1.562 0.98
161_N 333_H 1.561 0.98
296_S 382_L 1.554 0.98
458_T 492_A 1.538 0.98
106_E 110_Q 1.536 0.98
74_A 126_A 1.534 0.98
140_A 146_E 1.533 0.98
55_G 274_S 1.529 0.98
406_R 410_D 1.525 0.98
77_V 123_A 1.525 0.98
188_M 656_M 1.517 0.97
537_D 540_Q 1.515 0.97
174_V 368_L 1.513 0.97
165_F 168_A 1.51 0.97
226_V 231_V 1.503 0.97
203_K 230_N 1.502 0.97
400_Q 403_E 1.5 0.97
140_A 149_A 1.494 0.97
449_A 519_V 1.492 0.97
84_S 103_P 1.491 0.97
114_L 258_A 1.491 0.97
174_V 372_A 1.469 0.97
595_V 602_V 1.465 0.97
169_F 301_A 1.463 0.97
166_D 170_T 1.463 0.97
386_Q 402_I 1.458 0.97
615_R 676_D 1.458 0.97
366_D 704_N 1.455 0.96
591_V 607_M 1.448 0.96
197_A 206_L 1.442 0.96
407_T 410_D 1.442 0.96
65_A 131_Q 1.439 0.96
53_I 268_V 1.433 0.96
258_A 266_V 1.432 0.96
622_A 674_F 1.429 0.96
593_V 706_V 1.428 0.96
613_A 616_I 1.425 0.96
633_G 698_V 1.424 0.96
227_P 230_N 1.403 0.95
362_E 380_R 1.397 0.95
142_S 145_D 1.397 0.95
604_V 634_M 1.391 0.95
411_K 671_E 1.39 0.95
381_I 409_A 1.383 0.95
483_M 520_Y 1.375 0.95
35_A 237_Y 1.365 0.94
454_E 460_T 1.361 0.94
616_I 674_F 1.361 0.94
168_A 331_N 1.358 0.94
53_I 254_L 1.352 0.94
81_I 262_V 1.348 0.94
23_D 620_K 1.346 0.94
179_T 286_L 1.345 0.94
616_I 622_A 1.344 0.94
147_K 286_L 1.344 0.94
79_A 261_A 1.344 0.94
476_L 519_V 1.343 0.94
622_A 690_V 1.336 0.94
479_T 512_A 1.336 0.94
454_E 458_T 1.335 0.94
54_V 132_A 1.335 0.94
25_I 477_A 1.333 0.93
293_A 379_F 1.33 0.93
169_F 175_K 1.323 0.93
288_H 305_E 1.321 0.93
181_T 286_L 1.32 0.93
61_G 132_A 1.317 0.93
280_T 347_N 1.313 0.93
607_M 630_M 1.312 0.93
171_S 300_T 1.311 0.93
481_A 491_V 1.301 0.92
58_I 138_K 1.294 0.92
174_V 371_K 1.294 0.92
52_Y 127_A 1.291 0.92
517_S 520_Y 1.29 0.92
166_D 333_H 1.288 0.92
521_A 525_K 1.277 0.91
602_V 638_L 1.273 0.91
377_V 409_A 1.272 0.91
165_F 169_F 1.266 0.91
461_V 480_A 1.264 0.91
487_P 490_Q 1.263 0.91
367_E 715_R 1.259 0.91
428_E 596_H 1.254 0.90
49_A 264_R 1.254 0.90
68_T 130_V 1.237 0.90
63_L 132_A 1.234 0.89
303_S 335_G 1.232 0.89
221_A 231_V 1.231 0.89
602_V 706_V 1.231 0.89
189_A 275_I 1.227 0.89
125_A 129_L 1.223 0.89
207_W 234_I 1.221 0.89
404_C 588_G 1.216 0.89
110_Q 311_L 1.213 0.88
238_I 468_I 1.212 0.88
178_A 367_E 1.205 0.88
480_A 523_C 1.204 0.88
76_G 126_A 1.2 0.88
409_A 415_K 1.2 0.88
45_A 198_V 1.195 0.87
412_F 608_L 1.195 0.87
438_G 587_A 1.189 0.87
365_I 379_F 1.188 0.87
53_I 114_L 1.185 0.87
645_D 648_L 1.185 0.87
483_M 523_C 1.182 0.87
42_H 48_A 1.181 0.86
349_M 632_M 1.18 0.86
542_Q 549_T 1.179 0.86
524_M 528_E 1.179 0.86
531_A 543_F 1.178 0.86
608_L 671_E 1.176 0.86
384_D 402_I 1.175 0.86
116_V 266_V 1.175 0.86
178_A 371_K 1.167 0.86
287_Q 360_A 1.163 0.85
372_A 379_F 1.163 0.85
47_N 264_R 1.158 0.85
381_I 402_I 1.158 0.85
142_S 146_E 1.154 0.85
38_A 194_A 1.15 0.84
159_D 335_G 1.15 0.84
283_P 356_P 1.147 0.84
411_K 610_V 1.146 0.84
478_Q 619_P 1.145 0.84
402_I 406_R 1.143 0.84
72_Q 79_A 1.142 0.84
431_V 594_G 1.142 0.84
478_Q 618_N 1.142 0.84
408_G 588_G 1.14 0.84
626_V 630_M 1.139 0.84
126_A 129_L 1.139 0.84
197_A 255_A 1.13 0.83
370_E 707_Y 1.128 0.83
48_A 267_K 1.125 0.83
602_V 724_L 1.125 0.83
81_I 258_A 1.123 0.82
525_K 568_A 1.122 0.82
81_I 116_V 1.12 0.82
60_K 140_A 1.119 0.82
53_I 111_A 1.118 0.82
591_V 604_V 1.11 0.81
595_V 600_G 1.11 0.81
176_I 293_A 1.105 0.81
198_V 205_T 1.104 0.81
461_V 491_V 1.1 0.81
600_G 724_L 1.098 0.81
480_A 491_V 1.096 0.80
452_H 567_T 1.095 0.80
77_V 126_A 1.095 0.80
327_Y 362_E 1.094 0.80
204_L 226_V 1.093 0.80
169_F 172_A 1.093 0.80
366_D 376_P 1.091 0.80
176_I 371_K 1.087 0.80
146_E 149_A 1.086 0.79
173_A 296_S 1.084 0.79
410_D 415_K 1.084 0.79
209_S 238_I 1.083 0.79
459_V 484_L 1.08 0.79
475_I 512_A 1.08 0.79
536_F 540_Q 1.077 0.79
28_P 32_T 1.076 0.79
218_T 228_V 1.074 0.78
284_A 307_W 1.073 0.78
25_I 474_T 1.073 0.78
19_G 478_Q 1.073 0.78
142_S 149_A 1.073 0.78
79_A 262_V 1.064 0.78
531_A 541_S 1.064 0.78
407_T 610_V 1.064 0.78
63_L 112_I 1.064 0.78
719_I 723_K 1.063 0.77
52_Y 123_A 1.061 0.77
48_A 196_M 1.06 0.77
113_A 132_A 1.06 0.77
477_A 488_L 1.057 0.77
72_Q 84_S 1.057 0.77
66_L 112_I 1.052 0.76
83_A 102_G 1.05 0.76
52_Y 120_F 1.049 0.76
405_L 435_V 1.048 0.76
407_T 411_K 1.045 0.76
292_G 301_A 1.04 0.75
293_A 372_A 1.04 0.75
112_I 132_A 1.04 0.75
541_S 548_I 1.04 0.75
60_K 342_D 1.038 0.75
117_A 126_A 1.038 0.75
211_Q 241_G 1.037 0.75
359_M 703_A 1.037 0.75
186_S 642_L 1.036 0.75
73_K 131_Q 1.035 0.75
299_I 329_G 1.033 0.75
39_Y 269_M 1.029 0.74
165_F 333_H 1.029 0.74
359_M 717_Y 1.029 0.74
644_V 651_F 1.027 0.74
180_Y 367_E 1.025 0.74
404_C 610_V 1.024 0.74
200_D 203_K 1.019 0.73
82_T 85_N 1.019 0.73
209_S 245_K 1.018 0.73
54_V 113_A 1.017 0.73
411_K 673_I 1.014 0.73
293_A 364_A 1.012 0.72
141_Y 149_A 1.012 0.72
519_V 523_C 1.01 0.72
141_Y 146_E 1.009 0.72
714_V 719_I 1.008 0.72
297_G 374_I 1.008 0.72
144_A 286_L 1.007 0.72
171_S 294_D 1.006 0.72
465_M 472_S 1.006 0.72
482_E 615_R 1.003 0.71
327_Y 380_R 1.002 0.71
193_H 275_I 1.001 0.71
144_A 147_K 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rm6A20.97131000.099Contact Map0.8
1t3qB20.97541000.101Contact Map0.81
1ffvB20.98361000.105Contact Map0.787
1n62B20.98361000.106Contact Map0.813
2w3sB40.97131000.113Contact Map0.776
3uncA20.97811000.119Contact Map0.784
3zyvA40.97541000.129Contact Map0.713
3nvzC20.95771000.13Contact Map0.775
1vlbA10.95771000.139Contact Map0.773
1dgjA10.95771000.143Contact Map0.739
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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