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OPENSEQ.org
HYFC - Hydrogenase-4 component C
UniProt: P77858 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14211
Length: 315 (292)
Sequences: 3341
Seq/Len: 11.44
HYFC
Paralog alert: 0.25 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HYCD HYFC NUOH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
162_S 167_M 4.7 1.00
240_S 267_T 3.087 1.00
29_T 50_D 3.042 1.00
36_R 283_N 2.867 1.00
39_M 283_N 2.715 1.00
190_G 277_L 2.669 1.00
131_A 217_T 2.41 1.00
186_L 242_F 2.407 1.00
240_S 271_V 2.351 1.00
51_Y 54_I 2.3 1.00
83_M 234_K 2.178 1.00
194_F 281_A 2.167 1.00
197_M 278_A 2.16 1.00
247_L 274_I 2.132 1.00
243_V 267_T 2.102 1.00
236_V 275_F 2.075 1.00
178_S 186_L 2.068 1.00
239_A 274_I 2.056 1.00
58_F 225_A 2.001 1.00
175_G 179_P 1.982 1.00
191_F 301_F 1.968 1.00
71_M 121_L 1.905 1.00
39_M 280_I 1.833 1.00
83_M 233_L 1.819 1.00
249_F 266_V 1.806 1.00
167_M 170_N 1.793 1.00
171_T 177_N 1.781 1.00
190_G 194_F 1.778 1.00
193_C 238_M 1.768 1.00
213_E 216_L 1.751 1.00
156_L 168_I 1.746 1.00
25_T 233_L 1.67 1.00
189_C 242_F 1.657 1.00
160_A 177_N 1.636 1.00
107_T 111_L 1.565 1.00
75_M 121_L 1.56 1.00
86_L 237_V 1.55 1.00
62_E 223_G 1.546 1.00
88_M 107_T 1.542 1.00
38_R 43_R 1.534 1.00
56_K 60_R 1.517 1.00
51_Y 55_H 1.505 1.00
243_V 247_L 1.486 1.00
155_V 185_A 1.463 1.00
105_L 165_I 1.46 1.00
79_L 230_G 1.445 1.00
151_L 309_V 1.435 1.00
183_V 187_L 1.433 1.00
207_A 211_L 1.433 1.00
79_L 118_F 1.432 1.00
178_S 247_L 1.424 1.00
25_T 229_W 1.402 0.99
65_P 72_F 1.386 0.99
152_S 188_A 1.378 0.99
190_G 242_F 1.372 0.99
160_A 171_T 1.371 0.99
31_I 276_V 1.339 0.99
148_M 192_A 1.308 0.99
224_L 228_K 1.296 0.99
89_A 107_T 1.292 0.99
256_S 259_C 1.282 0.99
176_W 270_K 1.267 0.99
170_N 173_A 1.261 0.99
157_A 163_T 1.259 0.99
280_I 284_T 1.255 0.99
49_Q 53_D 1.242 0.98
189_C 193_C 1.241 0.98
249_F 253_Q 1.241 0.98
290_F 294_H 1.239 0.98
28_F 275_F 1.237 0.98
166_E 170_N 1.234 0.98
58_F 222_A 1.229 0.98
85_V 107_T 1.222 0.98
78_V 82_S 1.221 0.98
153_L 245_L 1.22 0.98
262_T 265_V 1.204 0.98
105_L 157_A 1.201 0.98
204_V 292_L 1.201 0.98
123_G 135_A 1.201 0.98
134_G 205_A 1.199 0.98
80_I 230_G 1.199 0.98
176_W 248_P 1.19 0.98
141_L 198_G 1.18 0.98
122_S 125_D 1.177 0.98
101_G 107_T 1.175 0.98
21_L 233_L 1.173 0.98
156_L 245_L 1.165 0.97
156_L 182_T 1.159 0.97
216_L 224_L 1.159 0.97
289_R 294_H 1.154 0.97
155_V 309_V 1.152 0.97
82_S 111_L 1.151 0.97
185_A 308_W 1.148 0.97
155_V 305_A 1.134 0.97
148_M 297_T 1.133 0.97
265_V 269_L 1.132 0.97
80_I 84_L 1.123 0.97
164_H 167_M 1.119 0.96
114_L 300_G 1.115 0.96
193_C 242_F 1.115 0.96
304_A 308_W 1.115 0.96
97_S 166_E 1.112 0.96
85_V 111_L 1.108 0.96
37_A 43_R 1.103 0.96
27_L 50_D 1.098 0.96
207_A 210_E 1.096 0.96
287_R 291_L 1.096 0.96
30_G 36_R 1.095 0.96
274_I 277_L 1.091 0.96
35_I 276_V 1.091 0.96
204_V 293_I 1.091 0.96
109_I 150_I 1.087 0.96
169_S 248_P 1.084 0.96
138_E 205_A 1.077 0.95
73_R 77_W 1.076 0.95
204_V 288_G 1.069 0.95
291_L 294_H 1.064 0.95
225_A 229_W 1.055 0.95
262_T 266_V 1.052 0.95
128_S 131_A 1.051 0.94
212_Q 217_T 1.05 0.94
148_M 305_A 1.045 0.94
35_I 279_S 1.044 0.94
162_S 168_I 1.04 0.94
75_M 118_F 1.036 0.94
60_R 299_L 1.036 0.94
273_L 277_L 1.028 0.94
108_L 237_V 1.027 0.94
243_V 271_V 1.025 0.93
33_R 42_R 1.023 0.93
275_F 279_S 1.021 0.93
35_I 39_M 1.02 0.93
240_S 244_A 1.019 0.93
124_L 127_G 1.017 0.93
86_L 234_K 1.016 0.93
45_P 49_Q 1.014 0.93
79_L 115_F 1.013 0.93
190_G 274_I 1.011 0.93
233_L 236_V 1.011 0.93
189_C 238_M 1.008 0.93
160_A 168_I 1.002 0.92
30_G 50_D 1.002 0.92
64_A 69_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4he8H20.9811000.117Contact Map0.68
2jpkA10.08897.30.971Contact Map0.757
1q2fA10.09524.60.974Contact Map0.501
4b1zM20.16513.50.975Contact Map0.18
2yevB20.26032.90.976Contact Map0.524
1xioA10.21.90.978Contact Map0
2ks1B10.1271.70.979Contact Map0
2ll2A10.08251.70.979Contact Map0.058
3dacP20.06671.70.979Contact Map0.642
1qleD10.13331.70.979Contact Map0.156
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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