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OPENSEQ.org
NUOH - NADH-quinone oxidoreductase subunit H
UniProt: P0AFD4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12088
Length: 325 (306)
Sequences: 3404
Seq/Len: 11.12
NUOH
Paralog alert: 0.24 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HYCD HYFC NUOH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
173_S 178_D 4.599 1.00
33_S 60_L 3.087 1.00
250_A 271_F 2.928 1.00
40_L 287_A 2.881 1.00
43_F 287_A 2.78 1.00
200_A 281_M 2.719 1.00
196_F 252_M 2.462 1.00
250_A 275_T 2.419 1.00
142_S 227_I 2.399 1.00
204_V 285_I 2.189 1.00
61_V 64_M 2.173 1.00
94_L 244_G 2.157 1.00
207_C 282_F 2.136 1.00
253_V 271_F 2.107 1.00
257_F 278_F 2.102 1.00
246_V 279_M 2.073 1.00
186_V 190_I 2.054 1.00
167_V 179_I 2.019 1.00
189_V 196_F 2.015 1.00
201_I 305_C 2.004 1.00
29_G 243_I 1.932 1.00
68_F 235_G 1.922 1.00
192_Q 195_G 1.918 1.00
82_I 132_F 1.905 1.00
249_S 278_F 1.905 1.00
169_A 317_A 1.879 1.00
182_S 188_N 1.842 1.00
171_A 188_N 1.84 1.00
178_D 181_N 1.803 1.00
94_L 243_I 1.76 1.00
200_A 204_V 1.752 1.00
43_F 284_L 1.742 1.00
253_V 257_F 1.703 1.00
203_G 248_I 1.678 1.00
199_F 252_M 1.64 1.00
223_D 226_H 1.616 1.00
99_A 118_F 1.614 1.00
72_D 233_K 1.573 1.00
61_V 65_I 1.569 1.00
118_F 122_M 1.563 1.00
29_G 239_V 1.554 1.00
86_A 132_F 1.528 1.00
116_I 176_M 1.526 1.00
262_G 270_W 1.526 1.00
189_V 257_F 1.473 1.00
162_L 313_L 1.465 1.00
90_A 240_G 1.46 1.00
90_A 129_A 1.457 1.00
97_A 247_T 1.455 1.00
19_V 23_L 1.437 1.00
42_L 47_Y 1.43 1.00
167_V 193_F 1.418 1.00
66_K 70_K 1.404 0.99
187_W 258_G 1.387 0.99
217_A 221_L 1.386 0.99
35_G 280_M 1.375 0.99
171_A 182_S 1.354 0.99
112_L 118_F 1.327 0.99
47_Y 50_N 1.314 0.99
75_P 83_F 1.313 0.99
234_F 238_F 1.308 0.99
163_S 198_T 1.295 0.99
200_A 252_M 1.295 0.99
284_L 288_S 1.287 0.99
164_L 255_L 1.279 0.99
52_V 59_Q 1.274 0.99
16_L 19_V 1.27 0.99
96_L 118_F 1.264 0.99
166_G 313_L 1.264 0.99
32_M 279_M 1.262 0.99
100_I 118_F 1.253 0.99
31_F 60_L 1.248 0.99
91_F 240_G 1.235 0.98
159_F 202_A 1.232 0.98
152_Q 297_V 1.23 0.98
152_Q 208_H 1.221 0.98
23_L 26_V 1.217 0.98
145_G 215_P 1.211 0.98
181_N 184_A 1.206 0.98
294_Y 298_M 1.202 0.98
168_V 174_F 1.199 0.98
277_F 281_M 1.199 0.98
195_G 256_F 1.198 0.98
199_F 203_G 1.198 0.98
177_T 181_N 1.189 0.98
214_Q 297_V 1.185 0.98
159_F 309_T 1.181 0.98
68_F 232_M 1.18 0.98
187_W 274_K 1.177 0.98
180_V 258_G 1.177 0.98
293_R 298_M 1.169 0.97
116_I 168_V 1.167 0.97
133_A 136_S 1.161 0.97
25_V 243_I 1.16 0.97
214_Q 296_Q 1.15 0.97
166_G 309_T 1.149 0.97
266_P 270_W 1.132 0.97
89_I 93_S 1.132 0.97
91_F 95_L 1.131 0.97
134_G 146_A 1.131 0.97
214_Q 292_P 1.129 0.97
139_N 142_S 1.128 0.97
167_V 255_L 1.126 0.97
125_L 304_I 1.116 0.96
269_I 273_L 1.11 0.96
173_S 179_I 1.102 0.96
149_A 215_P 1.101 0.96
254_T 259_G 1.098 0.96
42_L 50_N 1.096 0.96
308_L 312_N 1.095 0.96
37_R 46_R 1.095 0.96
59_Q 63_D 1.095 0.96
192_Q 316_T 1.087 0.96
84_T 88_M 1.087 0.96
16_L 20_V 1.087 0.96
23_L 27_T 1.086 0.96
41_G 47_Y 1.082 0.96
70_K 303_K 1.077 0.95
278_F 281_M 1.072 0.95
213_D 216_E 1.066 0.95
217_A 220_E 1.065 0.95
86_A 129_A 1.055 0.95
175_N 178_D 1.049 0.94
39_L 283_I 1.049 0.94
166_G 192_Q 1.041 0.94
279_M 283_I 1.037 0.94
39_L 280_M 1.037 0.94
203_G 252_M 1.036 0.94
96_L 122_M 1.034 0.94
120_L 161_G 1.032 0.94
226_H 234_F 1.028 0.94
34_F 40_L 1.027 0.94
252_M 278_F 1.026 0.94
91_F 236_L 1.025 0.93
81_V 85_L 1.023 0.93
253_V 275_T 1.021 0.93
90_A 126_A 1.021 0.93
295_D 298_M 1.02 0.93
245_I 279_M 1.018 0.93
291_R 295_D 1.015 0.93
222_A 227_I 1.015 0.93
128_Y 294_Y 1.015 0.93
135_W 138_N 1.008 0.93
33_S 242_Y 1.006 0.93
171_A 179_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4he8H20.99691000.062Contact Map0.702
2jpkA10.10776.90.972Contact Map0.803
4h25C20.067730.977Contact Map0
1xioA10.20312.60.977Contact Map0.559
1q90G10.11382.60.978Contact Map0.794
3mp7A10.20622.40.978Contact Map0.044
3dacP20.06462.40.978Contact Map0.651
1qleD10.12922.10.979Contact Map0.116
1q2fA10.09541.80.979Contact Map0.629
2qjyA60.20311.70.98Contact Map0.295
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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