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OPENSEQ.org
YPDE - Aminopeptidase YpdE
UniProt: P77585 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14152
Length: 345 (334)
Sequences: 2608
Seq/Len: 7.81
YPDE
Paralog alert: 0.78 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: FRVX SGCX YPDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
328_A 331_Q 4.65 1.00
27_L 31_D 3.832 1.00
267_A 272_P 3.431 1.00
27_L 45_V 2.803 1.00
23_R 63_M 2.771 1.00
268_E 332_R 2.666 1.00
132_Y 136_M 2.65 1.00
28_E 31_D 2.636 1.00
178_L 192_L 2.463 1.00
264_T 268_E 2.437 1.00
12_A 25_I 2.394 1.00
176_T 179_R 2.343 1.00
321_Q 324_Q 2.324 1.00
49_L 178_L 2.273 1.00
269_I 328_A 2.219 1.00
268_E 328_A 2.201 1.00
262_V 329_L 2.181 1.00
180_E 185_E 2.16 1.00
81_V 125_V 2.111 1.00
320_L 324_Q 2.085 1.00
24_Q 28_E 2.066 1.00
56_K 189_E 2.064 1.00
206_Q 287_A 2.048 1.00
144_D 315_D 2.034 1.00
7_K 11_E 2.033 1.00
38_R 211_A 2.012 1.00
48_R 189_E 1.969 1.00
48_R 191_W 1.956 1.00
263_E 267_A 1.934 1.00
304_T 307_G 1.91 1.00
314_A 319_I 1.903 1.00
56_K 191_W 1.89 1.00
10_S 162_G 1.89 1.00
258_L 298_V 1.845 1.00
30_A 47_I 1.841 1.00
58_M 214_P 1.821 1.00
27_L 39_F 1.813 1.00
51_E 189_E 1.808 1.00
9_L 22_V 1.807 1.00
33_L 179_R 1.793 1.00
238_Q 241_N 1.782 1.00
144_D 317_R 1.77 1.00
100_T 147_T 1.768 1.00
28_E 32_R 1.767 1.00
262_V 298_V 1.754 1.00
174_L 192_L 1.753 1.00
74_S 80_D 1.746 1.00
57_V 330_I 1.716 1.00
42_L 207_T 1.695 1.00
26_L 63_M 1.685 1.00
260_A 263_E 1.663 1.00
159_R 315_D 1.656 1.00
177_L 326_L 1.608 1.00
79_I 99_I 1.607 1.00
4_S 8_A 1.607 1.00
219_V 285_G 1.604 1.00
187_P 331_Q 1.558 1.00
177_L 327_S 1.552 1.00
23_R 39_F 1.551 1.00
179_R 183_D 1.514 1.00
65_E 163_K 1.512 1.00
35_K 47_I 1.501 0.99
39_F 45_V 1.496 0.99
20_Q 24_Q 1.492 0.99
63_M 194_A 1.485 0.99
56_K 215_D 1.483 0.99
263_E 275_A 1.48 0.99
50_N 189_E 1.473 0.99
26_L 171_C 1.471 0.99
15_I 84_V 1.455 0.99
265_V 328_A 1.444 0.99
127_I 140_I 1.436 0.99
16_A 84_V 1.432 0.99
169_L 314_A 1.423 0.99
41_G 209_T 1.42 0.99
261_W 329_L 1.41 0.99
129_A 135_V 1.402 0.99
265_V 332_R 1.394 0.99
79_I 146_V 1.386 0.99
30_A 175_V 1.384 0.99
37_V 45_V 1.368 0.99
272_P 321_Q 1.362 0.99
169_L 319_I 1.361 0.99
46_L 211_A 1.355 0.99
61_A 174_L 1.355 0.99
35_K 178_L 1.347 0.99
173_L 322_M 1.339 0.99
14_A 168_R 1.331 0.98
60_C 195_S 1.331 0.98
14_A 22_V 1.33 0.98
61_A 170_G 1.323 0.98
265_V 269_I 1.322 0.98
8_A 29_E 1.32 0.98
36_E 48_R 1.302 0.98
180_E 327_S 1.3 0.98
15_I 18_S 1.298 0.98
23_R 45_V 1.288 0.98
264_T 267_A 1.278 0.98
220_L 326_L 1.274 0.98
171_C 194_A 1.267 0.98
141_R 144_D 1.261 0.98
214_P 295_V 1.253 0.98
109_G 125_V 1.249 0.97
222_T 307_G 1.24 0.97
58_M 295_V 1.237 0.97
127_I 135_V 1.231 0.97
5_L 179_R 1.224 0.97
5_L 25_I 1.22 0.97
75_R 132_Y 1.22 0.97
59_I 330_I 1.219 0.97
40_D 44_S 1.217 0.97
70_V 146_V 1.213 0.97
180_E 324_Q 1.212 0.97
8_A 28_E 1.2 0.97
144_D 318_D 1.194 0.96
129_A 138_A 1.192 0.96
197_S 203_R 1.182 0.96
55_P 215_D 1.179 0.96
24_Q 27_L 1.178 0.96
27_L 37_V 1.175 0.96
263_E 273_L 1.175 0.96
8_A 11_E 1.169 0.96
8_A 25_I 1.166 0.96
58_M 193_V 1.164 0.96
172_Y 176_T 1.16 0.96
264_T 332_R 1.158 0.96
133_D 137_Q 1.157 0.96
131_S 134_E 1.153 0.95
63_M 171_C 1.152 0.95
133_D 136_M 1.146 0.95
90_A 148_F 1.145 0.95
44_S 207_T 1.141 0.95
35_K 49_L 1.136 0.95
33_L 178_L 1.136 0.95
83_P 89_M 1.13 0.95
122_A 157_H 1.129 0.95
19_E 43_G 1.128 0.95
198_E 308_H 1.127 0.95
10_S 14_A 1.122 0.94
139_G 142_P 1.121 0.94
108_P 153_Q 1.12 0.94
58_M 288_V 1.118 0.94
315_D 318_D 1.117 0.94
190_V 330_I 1.116 0.94
123_M 310_A 1.115 0.94
218_I 326_L 1.109 0.94
145_R 317_R 1.106 0.94
57_V 216_V 1.103 0.94
60_C 284_D 1.096 0.94
29_E 32_R 1.096 0.94
38_R 46_L 1.081 0.93
271_V 325_L 1.077 0.93
173_L 319_I 1.072 0.93
74_S 78_A 1.071 0.92
101_T 104_E 1.07 0.92
43_G 63_M 1.065 0.92
256_P 260_A 1.061 0.92
200_V 203_R 1.06 0.92
30_A 37_V 1.057 0.92
81_V 123_M 1.054 0.92
261_W 265_V 1.041 0.91
17_S 197_S 1.039 0.91
180_E 187_P 1.02 0.90
26_L 194_A 1.015 0.90
184_A 331_Q 1.009 0.89
25_I 28_E 1.009 0.89
199_E 308_H 1.003 0.89
4_S 7_K 1.002 0.89
81_V 146_V 1.001 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1y0yA10.9711000.354Contact Map0.75
2vpuA10.96231000.369Contact Map0.718
2wyrA120.92751000.376Contact Map0.8
2fvgA10.95361000.387Contact Map0.722
2ijzA120.95361000.391Contact Map0.254
1yloA611000.392Contact Map0.728
1vheA10.99711000.409Contact Map0.753
3isxA10.93331000.409Contact Map0.643
3vatA10.98261000.415Contact Map0.491
2gljA240.94491000.423Contact Map0.504
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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