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OPENSEQ.org
FRVX - Putative aminopeptidase FrvX
UniProt: P32153 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11862
Length: 356 (348)
Sequences: 1718
Seq/Len: 4.94
FRVX
Paralog alert: 0.67 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: FRVX SGCX YPDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
336_G 339_T 4.084 1.00
141_R 145_E 3.189 1.00
27_I 31_E 3.066 1.00
12_A 25_I 2.837 1.00
23_R 62_M 2.83 1.00
329_A 332_T 2.798 1.00
185_E 188_Q 2.761 1.00
27_I 45_F 2.742 1.00
277_N 336_G 2.724 1.00
187_L 199_G 2.673 1.00
28_N 31_E 2.433 1.00
80_F 134_I 2.379 1.00
213_Q 295_R 2.369 1.00
271_K 275_A 2.341 1.00
246_K 249_Q 2.248 1.00
7_Q 11_E 2.236 1.00
276_H 336_G 2.209 1.00
186_L 334_I 2.205 1.00
266_L 306_V 2.189 1.00
168_K 323_S 2.163 1.00
48_R 198_Y 2.158 1.00
55_K 198_Y 2.121 1.00
99_R 156_S 2.115 1.00
272_S 276_H 2.112 1.00
276_H 340_T 2.109 1.00
10_C 171_G 2.076 1.00
8_Q 25_I 2.022 1.00
78_L 98_I 2.011 1.00
49_K 187_L 2.003 1.00
26_L 180_C 1.999 1.00
136_I 149_V 1.981 1.00
188_Q 192_N 1.97 1.00
73_D 79_R 1.96 1.00
38_T 218_H 1.933 1.00
226_V 293_G 1.922 1.00
16_S 83_I 1.872 1.00
8_Q 29_T 1.861 1.00
64_E 172_K 1.859 1.00
78_L 155_I 1.846 1.00
15_V 83_I 1.824 1.00
56_V 338_L 1.791 1.00
328_E 332_T 1.772 1.00
37_I 45_F 1.771 1.00
189_T 193_P 1.761 1.00
30_L 47_A 1.748 1.00
108_G 134_I 1.7 1.00
7_Q 10_C 1.695 0.99
14_A 22_V 1.681 0.99
138_A 144_V 1.665 0.99
20_Q 43_G 1.614 0.99
270_L 337_F 1.613 0.99
69_V 155_I 1.59 0.99
153_N 326_D 1.581 0.99
59_V 202_S 1.579 0.99
42_L 214_T 1.572 0.99
322_I 327_Y 1.546 0.99
13_S 94_H 1.544 0.99
275_A 280_P 1.539 0.99
280_P 329_A 1.534 0.99
251_P 329_A 1.521 0.99
136_I 144_V 1.492 0.98
189_T 335_R 1.473 0.98
4_E 8_Q 1.471 0.98
14_A 177_R 1.469 0.98
30_L 184_A 1.468 0.98
57_A 296_Y 1.464 0.98
279_L 333_L 1.463 0.98
270_L 306_V 1.461 0.98
43_G 62_M 1.448 0.98
12_A 21_E 1.445 0.98
35_N 49_K 1.441 0.98
60_G 183_M 1.428 0.98
181_A 185_E 1.425 0.98
142_E 146_K 1.413 0.97
138_A 147_R 1.411 0.97
197_L 338_L 1.401 0.97
186_L 335_R 1.4 0.97
205_E 316_H 1.381 0.97
44_S 214_T 1.379 0.97
273_C 277_N 1.359 0.97
40_D 218_H 1.349 0.96
142_E 145_E 1.338 0.96
40_D 44_S 1.331 0.96
58_V 338_L 1.326 0.96
57_A 215_S 1.321 0.96
178_I 327_Y 1.319 0.96
268_A 271_K 1.312 0.96
33_C 187_L 1.307 0.96
220_K 300_G 1.307 0.96
27_I 39_F 1.302 0.95
114_A 135_D 1.301 0.95
57_A 219_I 1.296 0.95
36_E 48_R 1.296 0.95
143_E 146_K 1.294 0.95
264_Q 268_A 1.294 0.95
74_E 141_R 1.293 0.95
275_A 278_D 1.291 0.95
35_N 187_L 1.276 0.95
80_F 132_M 1.269 0.94
26_L 184_A 1.268 0.94
86_W 157_P 1.259 0.94
269_A 273_C 1.255 0.94
59_V 292_D 1.253 0.94
23_R 45_F 1.246 0.94
24_D 28_N 1.243 0.94
182_M 327_Y 1.239 0.94
335_R 339_T 1.236 0.93
26_L 201_G 1.236 0.93
271_K 283_F 1.229 0.93
217_E 300_G 1.216 0.93
107_P 162_A 1.216 0.93
312_T 315_L 1.212 0.93
132_M 318_N 1.207 0.92
33_C 191_N 1.204 0.92
272_S 275_A 1.197 0.92
189_T 332_T 1.182 0.91
82_T 88_N 1.181 0.91
100_T 103_G 1.178 0.91
227_L 334_I 1.174 0.91
248_G 323_S 1.172 0.91
39_F 45_F 1.169 0.91
255_L 283_F 1.156 0.90
98_I 155_I 1.155 0.90
206_E 316_H 1.152 0.90
57_A 200_V 1.152 0.90
140_S 143_E 1.151 0.90
167_D 325_A 1.149 0.90
5_L 29_T 1.13 0.89
33_C 188_Q 1.129 0.89
116_H 132_M 1.128 0.89
275_A 281_L 1.127 0.88
253_L 281_L 1.126 0.88
80_F 155_I 1.125 0.88
230_A 309_C 1.125 0.88
183_M 199_G 1.121 0.88
221_P 303_R 1.121 0.88
73_D 77_F 1.118 0.88
274_A 333_L 1.116 0.88
8_Q 28_N 1.115 0.88
193_P 339_T 1.115 0.88
55_K 222_D 1.109 0.87
141_R 144_V 1.086 0.86
323_S 326_D 1.085 0.86
253_L 267_V 1.085 0.86
23_R 39_F 1.083 0.86
7_Q 161_F 1.082 0.86
175_D 316_H 1.082 0.86
153_N 323_S 1.081 0.85
186_L 338_L 1.08 0.85
97_T 105_K 1.078 0.85
80_F 110_I 1.073 0.85
29_T 188_Q 1.073 0.85
3_I 163_C 1.071 0.85
144_V 149_V 1.068 0.85
180_C 201_G 1.066 0.84
25_I 28_N 1.065 0.84
232_A 326_D 1.064 0.84
62_M 180_C 1.064 0.84
121_K 124_Q 1.057 0.84
18_D 154_F 1.057 0.84
29_T 32_P 1.055 0.84
98_I 134_I 1.055 0.84
153_N 325_A 1.053 0.83
118_L 167_D 1.048 0.83
20_Q 39_F 1.048 0.83
254_M 286_M 1.041 0.82
313_R 326_D 1.04 0.82
271_K 281_L 1.039 0.82
96_V 134_I 1.038 0.82
185_E 327_Y 1.037 0.82
69_V 78_L 1.035 0.82
52_K 194_E 1.032 0.82
68_M 81_T 1.031 0.82
290_A 294_G 1.027 0.81
11_E 97_T 1.027 0.81
325_A 328_E 1.026 0.81
186_L 331_L 1.023 0.81
273_C 340_T 1.016 0.80
154_F 325_A 1.009 0.80
175_D 205_E 1.005 0.79
169_V 174_L 1.001 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ijzA120.95791000.382Contact Map0.252
1y0yA10.97191000.384Contact Map0.788
2vpuA10.96071000.402Contact Map0.734
2wyrA120.91851000.411Contact Map0.808
3vatA10.97751000.42Contact Map0.475
2gljA240.9411000.421Contact Map0.421
2fvgA10.94941000.421Contact Map0.724
2glfA40.93541000.436Contact Map0.55
3isxA10.93261000.44Contact Map0.651
1vheA10.99721000.443Contact Map0.784
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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