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OPENSEQ.org
GLXK2 - Glycerate kinase
UniProt: P77364 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13621
Length: 381 (377)
Sequences: 1139
Seq/Len: 3.02
GLXK2
Paralog alert: 0.37 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GLXK1 GLXK2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_S 114_T 3.82 1.00
67_G 71_E 3.552 1.00
273_L 278_L 2.887 1.00
269_I 307_G 2.857 1.00
139_V 205_A 2.726 1.00
295_I 321_G 2.659 1.00
143_M 153_F 2.592 1.00
77_Y 120_H 2.55 1.00
66_C 116_E 2.55 1.00
128_H 187_H 2.516 1.00
25_A 363_F 2.494 1.00
234_Q 240_N 2.463 1.00
241_V 255_I 2.399 1.00
5_I 23_I 2.326 1.00
29_T 367_R 2.315 1.00
128_H 189_E 2.293 1.00
42_A 48_T 2.24 1.00
279_A 311_V 2.144 1.00
367_R 371_C 2.135 1.00
23_I 366_A 2.133 1.00
294_R 325_V 2.083 1.00
71_E 103_K 2.081 1.00
22_A 26_G 2.059 1.00
279_A 314_Q 2.053 1.00
199_V 223_E 2.028 1.00
141_G 229_Y 2.027 1.00
29_T 363_F 2.024 1.00
27_F 370_A 2.003 1.00
24_K 38_C 1.99 1.00
20_C 38_C 1.961 1.00
214_A 222_L 1.941 1.00
166_G 225_G 1.907 0.99
79_L 126_I 1.864 0.99
147_Q 153_F 1.86 0.99
4_V 285_A 1.848 0.99
56_T 81_G 1.841 0.99
151_V 176_M 1.831 0.99
66_C 110_S 1.826 0.99
133_I 190_V 1.825 0.99
131_L 257_A 1.821 0.99
123_D 182_R 1.784 0.99
161_L 167_N 1.762 0.99
146_A 256_A 1.755 0.99
62_T 74_N 1.751 0.99
99_V 103_K 1.751 0.99
210_P 219_V 1.738 0.99
146_A 151_V 1.733 0.99
277_N 280_Q 1.716 0.98
64_E 74_N 1.711 0.98
191_A 271_I 1.703 0.98
21_Q 38_C 1.681 0.98
7_P 16_A 1.68 0.98
161_L 171_V 1.678 0.98
2_K 35_N 1.674 0.98
15_S 18_K 1.672 0.98
100_A 103_K 1.668 0.98
65_V 116_E 1.667 0.98
151_V 179_C 1.662 0.98
123_D 180_D 1.662 0.98
313_K 339_D 1.66 0.98
295_I 323_A 1.633 0.98
129_I 188_I 1.623 0.98
24_K 28_S 1.622 0.98
5_I 36_Y 1.611 0.97
14_L 358_G 1.607 0.97
7_P 20_C 1.592 0.97
68_P 98_L 1.589 0.97
111_S 138_T 1.588 0.97
231_R 242_C 1.588 0.97
41_I 304_A 1.588 0.97
284_G 317_V 1.583 0.97
84_K 127_R 1.58 0.97
127_R 185_N 1.58 0.97
350_P 353_E 1.574 0.97
61_V 124_N 1.549 0.97
67_G 73_V 1.532 0.96
187_H 264_D 1.531 0.96
215_T 218_M 1.526 0.96
80_T 87_V 1.526 0.96
76_F 92_A 1.52 0.96
53_V 78_G 1.52 0.96
93_A 114_T 1.519 0.96
278_L 311_V 1.519 0.96
3_I 287_L 1.515 0.96
27_F 36_Y 1.514 0.96
205_A 219_V 1.511 0.96
321_G 338_I 1.503 0.96
198_L 255_I 1.501 0.96
155_D 159_Q 1.483 0.95
90_M 253_M 1.465 0.95
37_I 281_A 1.463 0.95
153_F 171_V 1.456 0.95
299_T 306_L 1.453 0.95
19_C 362_L 1.443 0.94
18_K 359_E 1.44 0.94
66_C 70_G 1.438 0.94
192_C 265_I 1.438 0.94
127_R 186_C 1.43 0.94
90_M 133_I 1.425 0.94
152_R 175_E 1.418 0.94
146_A 260_F 1.396 0.93
7_P 23_I 1.379 0.92
233_L 255_I 1.375 0.92
23_I 289_I 1.373 0.92
12_E 97_M 1.369 0.92
282_V 317_V 1.366 0.92
233_L 260_F 1.359 0.92
111_S 256_A 1.358 0.92
9_S 46_E 1.343 0.91
129_I 186_C 1.337 0.91
195_D 202_R 1.332 0.91
280_Q 283_Q 1.322 0.90
279_A 315_F 1.317 0.90
122_L 182_R 1.311 0.90
164_N 167_N 1.309 0.90
325_V 348_L 1.306 0.89
205_A 214_A 1.305 0.89
85_T 128_H 1.299 0.89
41_I 273_L 1.296 0.89
147_Q 163_A 1.286 0.88
122_L 180_D 1.28 0.88
50_D 60_I 1.267 0.87
155_D 170_R 1.267 0.87
111_S 253_M 1.257 0.87
120_H 124_N 1.256 0.87
147_Q 164_N 1.254 0.87
322_I 366_A 1.253 0.87
162_A 167_N 1.244 0.86
143_M 171_V 1.241 0.86
152_R 160_A 1.239 0.86
282_V 311_V 1.237 0.86
199_V 242_C 1.237 0.86
64_E 72_K 1.231 0.85
2_K 284_G 1.23 0.85
214_A 219_V 1.229 0.85
274_N 311_V 1.224 0.85
60_I 76_F 1.212 0.84
105_N 218_M 1.202 0.83
282_V 288_V 1.197 0.83
118_I 188_I 1.193 0.83
12_E 104_R 1.193 0.83
65_V 75_A 1.192 0.83
349_A 354_V 1.188 0.82
77_Y 124_N 1.187 0.82
247_G 258_A 1.181 0.82
165_G 222_L 1.174 0.81
72_K 116_E 1.168 0.81
269_I 273_L 1.167 0.81
165_G 225_G 1.156 0.80
67_G 100_A 1.149 0.79
65_V 93_A 1.147 0.79
295_I 299_T 1.146 0.79
58_G 78_G 1.141 0.79
71_E 100_A 1.141 0.79
357_S 360_T 1.135 0.78
342_F 369_I 1.134 0.78
63_L 77_Y 1.113 0.76
50_D 54_A 1.112 0.76
342_F 372_A 1.106 0.76
14_L 19_C 1.105 0.76
349_A 361_N 1.101 0.75
206_A 220_E 1.09 0.74
162_A 171_V 1.087 0.74
164_N 171_V 1.086 0.74
309_A 338_I 1.084 0.74
190_V 265_I 1.082 0.74
12_E 355_L 1.081 0.73
105_N 108_L 1.073 0.73
143_M 161_L 1.072 0.73
197_P 247_G 1.069 0.72
135_G 193_D 1.067 0.72
189_E 266_K 1.063 0.72
107_L 221_E 1.058 0.71
133_I 250_A 1.053 0.71
24_K 36_Y 1.051 0.70
4_V 308_V 1.051 0.70
51_A 54_A 1.047 0.70
300_A 333_V 1.044 0.70
299_T 323_A 1.043 0.70
167_N 170_R 1.039 0.69
93_A 117_L 1.034 0.69
90_M 94_S 1.031 0.68
130_I 191_A 1.031 0.68
16_A 20_C 1.031 0.68
207_V 297_S 1.029 0.68
250_A 268_G 1.028 0.68
52_M 275_A 1.028 0.68
39_L 276_V 1.027 0.68
161_L 225_G 1.024 0.68
35_N 284_G 1.023 0.67
2_K 37_I 1.021 0.67
244_M 258_A 1.013 0.66
51_A 87_V 1.011 0.66
219_V 226_L 1.01 0.66
135_G 194_V 1.008 0.66
120_H 123_D 1.005 0.65
75_A 117_L 1.003 0.65
342_F 368_N 1.001 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cwcA20.99741000.003Contact Map0.747
1to6A20.97381000.031Contact Map0.717
2r75110.477782.30.964Contact Map0.135
1eyeA10.569663.40.969Contact Map0.049
4hb7A20.572263.10.969Contact Map0.064
3jx9A20.412154.70.971Contact Map0.291
1vimA40.456751.30.971Contact Map0.237
3ab8A20.653548.60.972Contact Map0.178
3mcmA20.514444.30.972Contact Map0.108
1aj0A10.569641.40.973Contact Map0.08
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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