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OPENSEQ.org
GLXK1 - Glycerate 2-kinase
UniProt: P23524 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11175
Length: 381 (376)
Sequences: 1135
Seq/Len: 3.02
GLXK1
Paralog alert: 0.37 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GLXK1 GLXK2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_S 114_T 3.812 1.00
67_G 71_E 3.588 1.00
273_T 278_L 2.888 1.00
269_I 307_G 2.869 1.00
139_N 205_S 2.714 1.00
295_I 321_G 2.65 1.00
66_T 116_E 2.584 1.00
143_A 153_L 2.566 1.00
77_W 120_Q 2.546 1.00
128_N 187_V 2.528 1.00
241_V 255_A 2.444 1.00
25_K 363_C 2.421 1.00
234_K 240_D 2.385 1.00
5_I 23_I 2.328 1.00
128_N 189_R 2.287 1.00
29_E 367_R 2.261 1.00
42_A 48_T 2.24 1.00
367_R 371_A 2.203 1.00
71_E 103_K 2.156 1.00
279_E 311_V 2.147 1.00
23_I 366_S 2.121 1.00
279_E 314_K 2.115 1.00
294_R 325_S 2.087 1.00
29_E 363_C 2.077 1.00
24_E 38_S 2.022 1.00
199_V 223_D 2.021 1.00
22_A 26_G 2.017 1.00
27_F 370_A 1.989 1.00
141_G 229_Y 1.957 1.00
20_A 38_S 1.945 1.00
214_A 222_L 1.936 0.99
166_G 225_N 1.896 0.99
66_T 110_T 1.896 0.99
79_I 126_A 1.896 0.99
147_Q 153_L 1.88 0.99
151_A 176_I 1.849 0.99
4_V 285_C 1.847 0.99
131_I 257_L 1.834 0.99
56_T 81_G 1.831 0.99
133_I 190_V 1.814 0.99
146_V 256_A 1.761 0.99
123_E 182_R 1.76 0.99
210_P 219_I 1.76 0.99
146_V 151_A 1.748 0.99
191_A 271_I 1.721 0.99
64_W 74_N 1.716 0.98
161_I 167_S 1.716 0.98
62_H 74_N 1.713 0.98
161_I 171_L 1.707 0.98
7_P 16_A 1.673 0.98
99_V 103_K 1.67 0.98
15_S 18_E 1.669 0.98
2_K 35_Q 1.662 0.98
129_I 188_I 1.66 0.98
65_V 116_E 1.659 0.98
295_I 323_A 1.648 0.98
100_P 103_K 1.641 0.98
21_Q 38_S 1.639 0.98
284_D 317_K 1.63 0.98
123_E 180_D 1.626 0.98
277_N 280_E 1.624 0.98
5_I 36_Y 1.624 0.98
68_P 98_L 1.609 0.97
14_L 358_A 1.608 0.97
111_S 138_T 1.607 0.97
151_A 179_L 1.602 0.97
24_E 28_R 1.596 0.97
7_P 20_A 1.586 0.97
231_E 242_K 1.579 0.97
350_T 353_E 1.576 0.97
313_K 339_D 1.571 0.97
41_V 304_V 1.57 0.97
215_S 218_M 1.562 0.97
155_D 159_N 1.559 0.97
278_L 311_V 1.559 0.97
321_G 338_I 1.554 0.97
84_K 127_T 1.549 0.97
76_S 92_A 1.542 0.96
93_A 114_T 1.538 0.96
27_F 36_Y 1.53 0.96
80_S 87_F 1.524 0.96
53_I 78_G 1.522 0.96
67_G 73_V 1.52 0.96
127_T 185_D 1.518 0.96
3_I 287_L 1.517 0.96
61_R 124_S 1.513 0.96
198_L 255_A 1.508 0.96
187_V 264_E 1.501 0.96
90_M 253_M 1.476 0.95
205_S 219_I 1.476 0.95
299_S 306_I 1.474 0.95
66_T 70_G 1.47 0.95
153_L 171_L 1.461 0.95
192_C 265_L 1.455 0.95
90_M 133_I 1.44 0.94
18_E 359_Y 1.434 0.94
37_V 281_H 1.424 0.94
19_V 362_I 1.42 0.94
127_T 186_C 1.419 0.94
233_I 255_A 1.413 0.94
146_V 260_F 1.409 0.93
152_K 175_D 1.389 0.93
233_I 260_F 1.382 0.93
195_T 202_N 1.376 0.92
23_I 289_I 1.363 0.92
214_A 219_I 1.358 0.92
12_E 97_E 1.357 0.92
129_I 186_C 1.355 0.92
7_P 23_I 1.346 0.91
282_I 317_K 1.338 0.91
122_L 182_R 1.338 0.91
111_S 256_A 1.332 0.91
279_E 315_Y 1.332 0.91
325_S 348_I 1.318 0.90
205_S 214_A 1.315 0.90
9_S 46_E 1.315 0.90
164_G 167_S 1.306 0.89
122_L 180_D 1.301 0.89
147_Q 163_F 1.285 0.88
280_E 283_H 1.282 0.88
155_D 170_T 1.277 0.88
50_E 60_E 1.275 0.88
120_Q 124_S 1.273 0.88
111_S 253_M 1.267 0.87
147_Q 164_G 1.263 0.87
2_K 284_D 1.259 0.87
41_V 273_T 1.252 0.87
152_K 160_E 1.252 0.87
282_I 288_V 1.246 0.86
282_I 311_V 1.245 0.86
85_T 128_N 1.242 0.86
143_A 171_L 1.236 0.86
162_G 167_S 1.229 0.85
349_G 354_A 1.223 0.85
77_W 124_S 1.222 0.85
199_V 242_K 1.218 0.85
60_E 76_S 1.218 0.85
65_V 75_A 1.218 0.85
342_F 372_T 1.213 0.84
269_I 273_T 1.21 0.84
274_T 311_V 1.209 0.84
322_I 366_S 1.195 0.83
247_A 258_M 1.193 0.83
165_G 222_L 1.191 0.83
165_G 225_N 1.184 0.82
295_I 299_S 1.179 0.82
71_E 100_P 1.174 0.81
72_K 116_E 1.172 0.81
105_D 218_M 1.17 0.81
12_E 104_R 1.17 0.81
64_W 72_K 1.154 0.80
342_F 369_I 1.149 0.79
67_G 100_P 1.147 0.79
118_I 188_I 1.142 0.79
65_V 93_A 1.138 0.79
309_A 338_I 1.137 0.79
58_G 78_G 1.129 0.78
63_A 77_W 1.11 0.76
357_G 360_D 1.106 0.76
14_L 19_V 1.103 0.76
162_G 171_L 1.1 0.75
349_G 361_N 1.097 0.75
197_P 247_A 1.096 0.75
50_E 54_A 1.091 0.74
206_R 220_V 1.086 0.74
189_R 266_K 1.086 0.74
190_V 265_L 1.083 0.74
143_A 161_I 1.079 0.73
287_L 318_P 1.069 0.72
105_D 108_V 1.065 0.72
12_E 355_F 1.062 0.72
164_G 171_L 1.06 0.71
93_A 117_L 1.06 0.71
135_G 193_D 1.06 0.71
167_S 170_T 1.052 0.71
75_A 117_L 1.052 0.71
90_M 94_S 1.049 0.70
300_I 333_V 1.048 0.70
130_I 191_A 1.042 0.69
24_E 36_Y 1.037 0.69
52_M 275_A 1.037 0.69
133_I 250_A 1.035 0.69
207_I 297_S 1.034 0.69
250_A 268_G 1.031 0.68
51_A 87_F 1.029 0.68
39_V 276_L 1.027 0.68
51_A 54_A 1.027 0.68
16_A 20_A 1.027 0.68
2_K 37_V 1.024 0.68
120_Q 123_E 1.023 0.67
14_L 359_Y 1.018 0.67
169_N 221_E 1.015 0.67
161_I 225_N 1.014 0.66
119_L 180_D 1.004 0.65
299_S 323_A 1.003 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cwcA20.99741000.009Contact Map0.759
1to6A20.97381000.035Contact Map0.733
2r75110.485669.80.968Contact Map0.151
1eyeA10.566968.30.969Contact Map0.048
4hb7A20.5696650.969Contact Map0.065
2xz9A20.703462.90.97Contact Map0.347
3jx9A20.417358.60.971Contact Map0.338
1vimA40.461955.90.971Contact Map0.255
3ab8A20.608941.70.973Contact Map0.242
2hwgA20.89538.50.974Contact Map0.307
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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