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MDLA - Multidrug resistance-like ATP-binding protein MdlA
UniProt: P77265 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11622
Length: 590 (570)
Sequences: 22627
Seq/Len: 39.70
MDLA
Paralog alert: 0.94 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: CYDC CYDD MDLA MDLB MSBA YDDA YOJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
452_H 462_Y 5.21 1.00
339_I 354_N 5.173 1.00
363_Q 539_E 4.821 1.00
336_D 358_A 4.625 1.00
360_K 363_Q 4.604 1.00
338_N 392_D 4.389 1.00
424_D 428_N 4.254 1.00
554_H 564_Y 4.251 1.00
539_E 551_R 4.08 1.00
427_A 439_Q 4.06 1.00
447_R 452_H 3.959 1.00
338_N 394_R 3.799 1.00
452_H 456_L 3.637 1.00
392_D 399_P 3.537 1.00
353_E 547_H 3.516 1.00
334_E 358_A 3.458 1.00
427_A 463_D 3.378 1.00
341_Q 354_N 3.355 1.00
438_T 441_E 3.325 1.00
446_A 462_Y 3.212 1.00
337_V 340_H 3.114 1.00
561_S 565_R 3.098 1.00
427_A 431_A 3.071 1.00
379_L 527_S 3.033 1.00
439_Q 443_E 3.003 1.00
430_I 446_A 2.934 1.00
565_R 569_R 2.894 1.00
434_C 441_E 2.86 1.00
379_L 495_I 2.755 1.00
444_H 448_L 2.742 1.00
413_A 491_A 2.736 1.00
553_N 556_V 2.717 1.00
357_F 541_I 2.668 1.00
359_L 365_L 2.662 1.00
384_R 387_D 2.632 1.00
336_D 394_R 2.599 1.00
550_Q 562_G 2.561 1.00
427_A 442_I 2.557 1.00
443_E 447_R 2.533 1.00
411_R 492_E 2.503 1.00
334_E 360_K 2.46 1.00
443_E 452_H 2.429 1.00
430_I 442_I 2.423 1.00
460_Q 464_T 2.408 1.00
404_Q 407_S 2.388 1.00
350_P 353_E 2.35 1.00
550_Q 561_S 2.349 1.00
451_V 454_D 2.338 1.00
341_Q 390_E 2.328 1.00
334_E 361_P 2.324 1.00
541_I 551_R 2.292 1.00
490_N 522_R 2.29 1.00
337_V 357_F 2.28 1.00
387_D 401_T 2.237 1.00
550_Q 560_Q 2.236 1.00
150_I 155_Q 2.187 1.00
364_M 537_A 2.166 1.00
552_G 556_V 2.082 1.00
544_Q 563_W 2.08 1.00
443_E 456_L 2.061 1.00
431_A 442_I 2.059 1.00
444_H 447_R 2.056 1.00
365_L 539_E 2.022 1.00
341_Q 350_P 2.014 1.00
339_I 356_N 2.012 1.00
516_R 536_E 2.01 1.00
6_Q 316_A 1.983 1.00
359_L 525_I 1.966 1.00
343_T 389_S 1.964 1.00
431_A 439_Q 1.945 1.00
446_A 455_I 1.923 1.00
343_T 350_P 1.91 1.00
445_V 449_A 1.89 1.00
441_E 490_N 1.873 1.00
335_L 525_I 1.857 1.00
367_I 378_L 1.82 1.00
440_Q 443_E 1.82 1.00
44_D 275_G 1.812 1.00
157_S 266_M 1.812 1.00
399_P 402_K 1.806 1.00
44_D 273_T 1.805 1.00
352_L 355_V 1.803 1.00
312_R 316_A 1.791 1.00
549_A 563_W 1.761 1.00
123_D 310_R 1.757 1.00
508_E 530_R 1.72 1.00
550_Q 565_R 1.717 1.00
541_I 548_I 1.716 1.00
450_S 510_Q 1.714 1.00
365_L 541_I 1.707 1.00
215_L 218_R 1.701 1.00
443_E 462_Y 1.683 1.00
333_G 396_H 1.678 1.00
503_V 511_I 1.677 1.00
441_E 444_H 1.667 1.00
354_N 547_H 1.657 1.00
528_A 533_A 1.655 1.00
364_M 526_I 1.651 1.00
378_L 543_M 1.645 1.00
448_L 517_Q 1.623 1.00
467_G 472_M 1.622 1.00
544_Q 549_A 1.609 1.00
453_D 456_L 1.585 1.00
426_V 481_I 1.582 1.00
10_Y 95_D 1.581 1.00
535_T 555_D 1.573 1.00
99_Q 103_Q 1.571 1.00
439_Q 463_D 1.57 1.00
363_Q 538_S 1.563 1.00
367_I 541_I 1.563 1.00
99_Q 319_P 1.537 1.00
265_W 269_Q 1.533 1.00
558_A 568_Y 1.533 1.00
383_Q 414_V 1.53 1.00
388_V 400_L 1.517 1.00
437_A 488_L 1.517 1.00
509_H 513_H 1.492 1.00
446_A 452_H 1.489 1.00
366_G 537_A 1.485 1.00
430_I 488_L 1.478 1.00
556_V 560_Q 1.476 1.00
342_F 377_T 1.453 1.00
393_I 400_L 1.452 1.00
192_A 229_D 1.451 1.00
517_Q 520_Q 1.45 1.00
466_V 473_L 1.448 1.00
323_D 404_Q 1.443 1.00
431_A 437_A 1.428 1.00
475_G 480_R 1.425 1.00
371_T 507_T 1.422 1.00
395_F 493_I 1.42 1.00
460_Q 465_E 1.414 1.00
334_E 396_H 1.397 0.99
360_K 539_E 1.39 0.99
458_L 464_T 1.381 0.99
455_I 462_Y 1.371 0.99
342_F 386_F 1.369 0.99
540_I 554_H 1.366 0.99
451_V 455_I 1.364 0.99
357_F 378_L 1.351 0.99
445_V 487_L 1.349 0.99
513_H 517_Q 1.346 0.99
423_S 465_E 1.345 0.99
439_Q 442_I 1.344 0.99
413_A 486_A 1.342 0.99
370_P 563_W 1.339 0.99
448_L 487_L 1.336 0.99
355_V 378_L 1.334 0.99
109_L 386_F 1.327 0.99
219_Q 432_L 1.324 0.99
434_C 437_A 1.318 0.99
381_L 393_I 1.316 0.99
563_W 566_D 1.316 0.99
528_A 534_L 1.315 0.99
441_E 488_L 1.314 0.99
211_K 216_E 1.312 0.99
206_S 420_F 1.307 0.99
153_S 161_T 1.282 0.99
187_K 309_S 1.28 0.99
370_P 544_Q 1.277 0.99
340_H 388_V 1.275 0.99
158_W 162_L 1.274 0.99
221_A 225_A 1.267 0.99
153_S 158_W 1.263 0.99
555_D 559_Q 1.262 0.99
454_D 477_Q 1.261 0.99
199_R 226_D 1.255 0.99
61_A 65_L 1.246 0.98
440_Q 444_H 1.245 0.98
332_R 396_H 1.238 0.98
342_F 381_L 1.237 0.98
457_R 477_Q 1.235 0.98
366_G 534_L 1.233 0.98
519_G 524_V 1.23 0.98
102_R 319_P 1.225 0.98
195_S 229_D 1.225 0.98
159_Q 271_S 1.221 0.98
181_A 184_E 1.221 0.98
96_Y 314_M 1.219 0.98
446_A 451_V 1.213 0.98
173_I 177_R 1.213 0.98
355_V 548_I 1.211 0.98
335_L 395_F 1.203 0.98
14_E 91_E 1.202 0.98
456_L 461_G 1.2 0.98
339_I 390_E 1.197 0.98
337_V 382_I 1.196 0.98
437_A 441_E 1.194 0.98
223_F 227_A 1.192 0.98
12_R 15_W 1.186 0.98
36_P 283_Y 1.185 0.98
338_N 356_N 1.178 0.98
454_D 458_L 1.17 0.97
382_I 525_I 1.167 0.97
217_D 221_A 1.16 0.97
99_Q 315_L 1.158 0.97
266_M 271_S 1.157 0.97
473_L 481_I 1.156 0.97
152_M 280_F 1.156 0.97
40_G 44_D 1.155 0.97
336_D 397_D 1.154 0.97
398_I 402_K 1.153 0.97
398_I 403_L 1.152 0.97
543_M 548_I 1.146 0.97
40_G 279_S 1.146 0.97
467_G 470_G 1.145 0.97
341_Q 353_E 1.143 0.97
388_V 393_I 1.141 0.97
324_G 402_K 1.141 0.97
430_I 481_I 1.14 0.97
438_T 488_L 1.133 0.97
425_T 428_N 1.132 0.97
160_L 280_F 1.131 0.97
57_L 61_A 1.13 0.97
415_V 486_A 1.13 0.97
460_Q 463_D 1.128 0.97
456_L 462_Y 1.126 0.97
273_T 276_Q 1.125 0.97
443_E 446_A 1.124 0.97
450_S 507_T 1.124 0.97
126_R 307_A 1.121 0.97
483_I 496_L 1.12 0.96
203_S 219_Q 1.115 0.96
365_L 525_I 1.112 0.96
359_L 523_T 1.112 0.96
371_T 480_R 1.111 0.96
427_A 462_Y 1.106 0.96
112_R 115_D 1.102 0.96
442_I 462_Y 1.096 0.96
364_M 524_V 1.096 0.96
219_Q 222_L 1.095 0.96
405_L 409_R 1.093 0.96
337_V 378_L 1.093 0.96
109_L 380_S 1.089 0.96
192_A 195_S 1.08 0.95
466_V 472_M 1.078 0.95
554_H 558_A 1.066 0.95
192_A 233_K 1.064 0.95
451_V 457_R 1.056 0.95
445_V 488_L 1.052 0.95
395_F 408_W 1.05 0.94
340_H 381_L 1.044 0.94
111_H 115_D 1.037 0.94
334_E 397_D 1.03 0.94
115_D 194_S 1.028 0.94
444_H 490_N 1.026 0.94
415_V 483_I 1.022 0.93
361_P 492_E 1.022 0.93
336_D 356_N 1.021 0.93
450_S 513_H 1.021 0.93
453_D 457_R 1.021 0.93
383_Q 495_I 1.017 0.93
33_L 147_A 1.012 0.93
236_R 239_R 1.008 0.93
336_D 392_D 1.007 0.93
119_R 313_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qf4B10.97631000.168Contact Map0.726
4f4cA10.99831000.173Contact Map0.73
3b60A40.96951000.173Contact Map0.742
3b5xA20.96951000.173Contact Map0.1
4a82A40.96611000.173Contact Map0.077
3qf4A10.97971000.181Contact Map0.746
2yl4A10.98471000.184Contact Map0.714
3g5uA20.99831000.186Contact Map0.675
3nh6A10.51531000.446Contact Map0.776
3vx4A20.45761000.511Contact Map0.84
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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