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MURR - HTH-type transcriptional regulator MurR
UniProt: P77245 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14161
Length: 285 (281)
Sequences: 2690
Seq/Len: 9.57
MURR
Paralog alert: 0.77 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: HEXR MURR RPIR YFHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
214_A 227_A 3.722 1.00
128_I 213_I 3.461 1.00
136_P 183_G 3.38 1.00
194_S 222_P 3.207 1.00
128_I 229_F 3.13 1.00
188_A 202_A 3.115 1.00
60_A 69_A 2.907 1.00
11_G 23_D 2.907 1.00
206_R 228_H 2.791 1.00
153_L 157_L 2.735 1.00
28_N 31_E 2.724 1.00
130_E 265_L 2.671 1.00
202_A 212_V 2.641 1.00
131_V 211_T 2.547 1.00
129_I 261_G 2.417 1.00
185_V 213_I 2.315 1.00
24_F 28_N 2.287 1.00
22_A 54_F 2.231 1.00
110_E 114_E 2.157 1.00
140_I 153_L 2.154 1.00
187_I 215_I 2.121 1.00
136_P 184_D 2.05 1.00
55_A 66_L 2.018 1.00
231_L 254_V 1.986 1.00
203_E 226_L 1.984 1.00
131_V 229_F 1.963 1.00
132_I 187_I 1.915 1.00
189_I 215_I 1.883 1.00
202_A 223_L 1.881 1.00
11_G 19_Q 1.879 1.00
18_E 57_K 1.874 1.00
35_V 43_Q 1.846 1.00
150_G 189_I 1.842 1.00
180_L 210_A 1.823 1.00
205_A 210_A 1.812 1.00
96_D 104_K 1.79 1.00
153_L 187_I 1.79 1.00
140_I 157_L 1.759 1.00
23_D 27_A 1.738 1.00
127_K 229_F 1.72 1.00
188_A 212_V 1.7 1.00
131_V 185_V 1.68 1.00
211_T 228_H 1.679 1.00
61_Q 65_E 1.671 1.00
266_N 269_E 1.665 1.00
153_L 255_T 1.663 1.00
21_I 54_F 1.639 1.00
140_I 150_G 1.603 1.00
116_T 234_V 1.603 1.00
121_D 124_R 1.602 1.00
32_L 70_L 1.579 1.00
40_M 51_I 1.567 1.00
106_N 113_L 1.565 1.00
149_V 255_T 1.559 1.00
214_A 230_T 1.555 1.00
15_T 57_K 1.55 1.00
40_M 63_F 1.549 1.00
52_V 62_G 1.546 1.00
140_I 187_I 1.538 1.00
181_K 184_D 1.526 1.00
208_Q 276_R 1.522 1.00
17_N 50_S 1.506 1.00
133_S 262_L 1.506 1.00
124_R 127_K 1.504 1.00
132_I 185_V 1.5 1.00
137_F 163_R 1.484 1.00
188_A 198_I 1.464 1.00
31_E 43_Q 1.462 1.00
189_I 255_T 1.462 1.00
63_F 67_R 1.46 1.00
186_Q 205_A 1.459 1.00
132_I 138_I 1.45 1.00
180_L 186_Q 1.444 1.00
19_Q 23_D 1.417 0.99
151_R 168_A 1.4 0.99
60_A 66_L 1.394 0.99
21_I 44_L 1.393 0.99
135_A 185_V 1.378 0.99
25_L 66_L 1.375 0.99
37_S 52_V 1.375 0.99
133_S 266_N 1.365 0.99
138_I 162_Y 1.362 0.99
124_R 128_I 1.341 0.99
200_L 203_E 1.31 0.99
139_Q 180_L 1.297 0.99
129_I 265_L 1.29 0.99
180_L 184_D 1.288 0.99
103_R 117_C 1.282 0.99
68_M 71_I 1.277 0.99
10_A 13_E 1.27 0.99
21_I 50_S 1.269 0.99
186_Q 210_A 1.267 0.99
133_S 265_L 1.267 0.99
111_L 114_E 1.256 0.98
37_S 51_I 1.251 0.98
130_E 134_K 1.249 0.98
109_K 256_D 1.248 0.98
154_S 164_V 1.246 0.98
126_Q 261_G 1.239 0.98
97_S 100_V 1.238 0.98
233_T 251_Q 1.233 0.98
5_T 9_N 1.231 0.98
131_V 213_I 1.227 0.98
149_V 189_I 1.216 0.98
24_F 35_V 1.214 0.98
152_D 156_K 1.211 0.98
137_F 184_D 1.21 0.98
140_I 164_V 1.203 0.98
136_P 181_K 1.181 0.97
18_E 21_I 1.178 0.97
141_T 186_Q 1.169 0.97
162_Y 262_L 1.169 0.97
212_V 227_A 1.163 0.97
145_G 244_S 1.161 0.97
128_I 258_L 1.155 0.97
124_R 229_F 1.153 0.97
171_H 197_E 1.146 0.97
190_S 223_L 1.138 0.97
24_F 44_L 1.137 0.97
11_G 22_A 1.137 0.97
214_A 223_L 1.126 0.96
20_K 45_G 1.117 0.96
199_V 214_A 1.113 0.96
152_D 248_R 1.113 0.96
24_F 43_Q 1.092 0.95
157_L 262_L 1.09 0.95
38_R 48_Q 1.084 0.95
31_E 35_V 1.079 0.95
37_S 41_A 1.075 0.95
54_F 58_L 1.073 0.95
17_N 20_K 1.073 0.95
204_A 207_K 1.066 0.95
140_I 189_I 1.065 0.95
3_Y 7_I 1.052 0.94
17_N 21_I 1.051 0.94
137_F 165_A 1.048 0.94
135_A 138_I 1.048 0.94
190_S 193_G 1.044 0.94
233_T 254_V 1.038 0.94
44_L 49_S 1.036 0.93
183_G 211_T 1.036 0.93
154_S 166_C 1.036 0.93
64_T 67_R 1.028 0.93
224_R 230_T 1.02 0.93
132_I 135_A 1.02 0.93
206_R 226_L 1.005 0.92
24_F 31_E 1.003 0.92
49_S 53_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ivnA20.95441000.158Contact Map0.845
3shoA40.64911000.519Contact Map0.871
2xhzA40.63161000.557Contact Map0.828
3fxaA40.680799.90.569Contact Map0.859
3etnA40.712399.90.572Contact Map0.75
1m3sA20.624699.90.578Contact Map0.807
1jeoA10.61499.90.581Contact Map0.757
1vimA40.670299.90.582Contact Map0.854
3iwfA20.371999.90.6Contact Map0.856
2o3fA30.371999.90.6Contact Map0.755
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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