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YFHH - Uncharacterized HTH-type transcriptional regulator YfhH
UniProt: P37767 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12308
Length: 282 (280)
Sequences: 2698
Seq/Len: 9.64
YFHH
Paralog alert: 0.77 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: HEXR MURR RPIR YFHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
211_A 224_A 3.661 1.00
125_C 210_L 3.484 1.00
133_R 180_D 3.328 1.00
191_V 219_A 3.172 1.00
185_A 199_A 3.153 1.00
125_C 226_H 3.088 1.00
60_Y 69_A 2.895 1.00
11_Y 23_D 2.857 1.00
203_L 225_S 2.729 1.00
28_Q 31_T 2.722 1.00
127_T 262_Q 2.715 1.00
150_F 154_L 2.701 1.00
199_A 209_V 2.665 1.00
128_M 208_K 2.46 1.00
126_V 258_A 2.448 1.00
182_L 210_L 2.302 1.00
24_Y 28_Q 2.278 1.00
22_A 54_F 2.17 1.00
107_T 111_Y 2.134 1.00
137_L 150_F 2.115 1.00
184_L 212_I 2.093 1.00
55_A 66_L 2.088 1.00
133_R 181_D 2.053 1.00
129_L 184_L 2.003 1.00
147_A 186_I 1.983 1.00
200_D 223_R 1.967 1.00
18_D 57_K 1.94 1.00
199_A 220_L 1.915 1.00
228_L 251_L 1.905 1.00
186_I 212_I 1.896 1.00
35_L 43_E 1.889 1.00
128_M 226_H 1.885 1.00
11_Y 19_K 1.858 1.00
93_D 101_K 1.846 1.00
177_S 207_G 1.827 1.00
150_F 184_L 1.79 1.00
202_M 207_G 1.784 1.00
263_D 266_L 1.772 1.00
137_L 154_L 1.77 1.00
61_K 65_A 1.765 1.00
23_D 27_L 1.752 1.00
208_K 225_S 1.738 1.00
124_E 226_H 1.728 1.00
128_M 182_L 1.726 1.00
150_F 252_T 1.692 1.00
118_S 121_K 1.683 1.00
205_V 273_H 1.633 1.00
185_A 209_V 1.629 1.00
21_L 54_F 1.626 1.00
146_V 252_T 1.613 1.00
137_L 184_L 1.61 1.00
40_L 51_V 1.592 1.00
52_V 62_G 1.589 1.00
40_L 63_F 1.586 1.00
129_L 182_L 1.583 1.00
113_T 231_I 1.571 1.00
137_L 147_A 1.562 1.00
134_R 160_N 1.547 1.00
211_A 227_C 1.539 1.00
15_A 57_K 1.535 1.00
32_A 70_L 1.528 1.00
177_S 183_L 1.51 1.00
103_I 110_M 1.506 1.00
183_L 202_M 1.504 1.00
130_R 259_L 1.501 1.00
17_S 50_S 1.495 1.00
186_I 252_T 1.478 1.00
121_K 124_E 1.468 1.00
60_Y 66_L 1.456 1.00
25_L 66_L 1.454 1.00
63_F 67_K 1.454 1.00
178_S 181_D 1.442 1.00
31_T 43_E 1.435 1.00
130_R 263_D 1.427 1.00
185_A 195_L 1.424 1.00
19_K 23_D 1.423 1.00
129_L 135_I 1.419 0.99
21_L 44_A 1.412 0.99
132_A 182_L 1.41 0.99
37_S 52_V 1.374 0.99
148_Q 165_R 1.353 0.99
121_K 125_C 1.344 0.99
126_V 262_Q 1.324 0.99
183_L 207_G 1.324 0.99
197_L 200_D 1.321 0.99
94_P 97_L 1.292 0.99
136_I 177_S 1.286 0.99
177_S 181_D 1.283 0.99
128_M 210_L 1.278 0.99
123_H 258_A 1.275 0.99
100_E 114_L 1.271 0.99
108_A 111_Y 1.262 0.99
230_T 248_Q 1.262 0.99
21_L 50_S 1.262 0.99
135_I 159_F 1.247 0.98
68_L 71_S 1.245 0.98
106_N 253_D 1.244 0.98
127_T 131_S 1.242 0.98
37_S 51_V 1.233 0.98
5_L 9_Q 1.232 0.98
241_S 244_A 1.227 0.98
134_R 181_D 1.227 0.98
24_Y 35_L 1.222 0.98
121_K 226_H 1.221 0.98
133_R 178_S 1.221 0.98
137_L 161_A 1.22 0.98
130_R 262_Q 1.218 0.98
149_N 153_K 1.207 0.98
10_R 13_G 1.206 0.98
146_V 186_I 1.193 0.98
159_F 259_L 1.192 0.98
187_S 220_L 1.171 0.97
211_A 220_L 1.17 0.97
125_C 255_L 1.169 0.97
18_D 21_L 1.162 0.97
138_T 183_L 1.153 0.97
151_A 161_A 1.139 0.97
209_V 224_A 1.131 0.96
142_A 241_S 1.128 0.96
221_Q 227_C 1.127 0.96
24_Y 44_A 1.125 0.96
230_T 251_L 1.119 0.96
31_T 35_L 1.116 0.96
11_Y 22_A 1.114 0.96
20_K 45_G 1.106 0.96
154_L 259_L 1.091 0.95
201_E 204_R 1.078 0.95
168_H 194_E 1.074 0.95
24_Y 43_E 1.067 0.95
37_S 41_A 1.064 0.95
38_Q 48_Q 1.063 0.95
180_D 208_K 1.062 0.95
17_S 20_K 1.061 0.94
196_N 211_A 1.055 0.94
187_S 190_G 1.052 0.94
132_A 135_I 1.04 0.94
54_F 58_L 1.04 0.94
129_L 132_A 1.04 0.94
134_R 162_A 1.037 0.94
64_P 67_K 1.033 0.93
44_A 49_S 1.021 0.93
17_S 21_L 1.02 0.93
149_N 245_C 1.016 0.93
137_L 186_I 1.016 0.93
24_Y 31_T 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ivnA20.92911000.139Contact Map0.846
3shoA40.65251000.519Contact Map0.868
2xhzA40.60641000.551Contact Map0.826
3fxaA40.670299.90.571Contact Map0.856
3etnA40.666799.90.574Contact Map0.76
1m3sA20.631299.90.578Contact Map0.808
1vimA40.648999.90.58Contact Map0.855
1jeoA10.599399.90.58Contact Map0.756
3iwfA20.315699.90.59Contact Map0.851
2o3fA30.269599.90.591Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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