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DSBG - Thiol:disulfide interchange protein DsbG
UniProt: P77202 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13535
Length: 248 (228)
Sequences: 628
Seq/Len: 2.75
DSBG
Paralog alert: 0.61 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DSBC DSBG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
174_K 178_Q 3.299 1.00
168_A 198_Q 2.868 1.00
79_N 82_N 2.765 1.00
125_F 162_T 2.596 1.00
158_E 162_T 2.349 1.00
135_Q 238_Q 2.291 1.00
110_G 114_A 2.276 1.00
114_A 146_Q 2.217 1.00
109_D 177_Q 2.205 1.00
171_D 174_K 2.165 1.00
156_K 159_S 2.129 1.00
160_P 164_A 2.067 1.00
71_Y 79_N 1.889 0.99
125_F 159_S 1.86 0.99
105_H 205_N 1.837 0.99
44_M 68_I 1.76 0.99
111_K 146_Q 1.748 0.98
208_L 212_L 1.709 0.98
154_V 159_S 1.689 0.98
68_I 72_M 1.687 0.98
135_Q 235_L 1.665 0.98
221_Y 231_Q 1.655 0.98
110_G 146_Q 1.65 0.97
166_I 179_Y 1.648 0.97
109_D 149_T 1.64 0.97
106_W 148_R 1.639 0.97
212_L 221_Y 1.636 0.97
169_S 175_T 1.604 0.97
111_K 114_A 1.598 0.97
105_H 204_D 1.54 0.96
117_I 148_R 1.534 0.96
152_V 209_M 1.508 0.95
47_Y 62_P 1.447 0.93
125_F 156_K 1.446 0.93
176_W 180_E 1.445 0.93
122_A 133_W 1.428 0.93
21_P 24_V 1.425 0.93
178_Q 182_S 1.414 0.92
121_F 208_L 1.403 0.92
136_A 139_W 1.365 0.91
20_L 23_P 1.344 0.90
119_Y 150_L 1.325 0.89
204_D 207_K 1.312 0.88
233_V 236_P 1.31 0.88
164_A 241_L 1.306 0.88
127_P 156_K 1.286 0.87
159_S 163_A 1.274 0.86
118_V 139_W 1.272 0.86
118_V 241_L 1.268 0.86
119_Y 148_R 1.253 0.85
65_K 74_N 1.243 0.84
41_P 74_N 1.242 0.84
178_Q 183_G 1.23 0.83
171_D 175_T 1.23 0.83
166_I 201_V 1.225 0.83
73_Y 172_P 1.222 0.83
120_V 221_Y 1.212 0.82
37_T 49_G 1.196 0.81
153_G 157_P 1.19 0.80
109_D 173_A 1.186 0.80
131_Q 135_Q 1.185 0.80
49_G 60_L 1.17 0.79
51_Y 127_P 1.166 0.79
106_W 119_Y 1.164 0.78
117_I 146_Q 1.156 0.78
232_A 239_K 1.151 0.77
133_W 149_T 1.15 0.77
67_A 72_M 1.148 0.77
81_S 84_L 1.147 0.77
25_K 28_E 1.147 0.77
135_Q 138_P 1.144 0.77
237_D 240_T 1.143 0.77
164_A 202_L 1.139 0.76
143_G 148_R 1.134 0.76
48_L 84_L 1.128 0.75
72_M 80_L 1.126 0.75
214_A 232_A 1.118 0.74
240_T 243_I 1.111 0.74
139_W 145_V 1.103 0.73
152_V 157_P 1.097 0.72
154_V 157_P 1.088 0.71
115_P 144_K 1.087 0.71
109_D 127_P 1.084 0.71
208_L 219_A 1.082 0.71
145_V 202_L 1.072 0.70
167_L 172_P 1.068 0.69
73_Y 82_N 1.064 0.69
108_L 148_R 1.062 0.69
80_L 199_M 1.059 0.68
47_Y 85_I 1.055 0.68
116_V 223_M 1.049 0.67
114_A 148_R 1.046 0.67
209_M 233_V 1.039 0.66
58_I 208_L 1.037 0.66
109_D 133_W 1.034 0.66
58_I 67_A 1.033 0.66
102_E 106_W 1.032 0.66
130_K 188_L 1.024 0.65
65_K 207_K 1.017 0.64
58_I 69_S 1.016 0.64
120_V 132_F 1.014 0.64
127_P 180_E 1.012 0.63
173_A 197_E 1.01 0.63
132_F 241_L 1.006 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v58A20.91941000.302Contact Map0.542
1t3bA10.81851000.396Contact Map0.589
3tdgA10.88711000.427Contact Map0.421
1eejA20.81851000.437Contact Map0.659
3gv1A30.544499.90.672Contact Map0.662
3ghaA10.637199.80.698Contact Map0.437
3f4sA10.677499.80.705Contact Map0.43
3gmfA10.576699.80.705Contact Map0.496
3bciA10.556599.80.709Contact Map0.439
1z6mA10.596899.80.713Contact Map0.517
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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