May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
DSBC - Thiol:disulfide interchange protein DsbC
UniProt: P0AEG6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11070
Length: 236 (214)
Sequences: 655
Seq/Len: 3.06
DSBC
Paralog alert: 0.59 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DSBC DSBG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
161_C 183_C 3.51 1.00
167_K 171_D 3.024 1.00
117_T 155_E 2.481 1.00
102_K 106_E 2.191 1.00
73_D 76_G 2.142 1.00
106_E 137_T 2.039 1.00
127_Q 219_P 1.962 1.00
81_N 84_N 1.952 1.00
164_D 167_K 1.913 0.99
67_I 71_M 1.84 0.99
143_F 194_G 1.809 0.99
151_D 155_E 1.792 0.99
193_L 197_L 1.777 0.99
149_D 152_A 1.756 0.99
153_E 157_K 1.754 0.99
206_V 212_L 1.74 0.99
97_E 189_D 1.728 0.99
101_Y 170_D 1.704 0.98
102_K 137_T 1.689 0.98
159_I 172_V 1.642 0.98
103_A 137_T 1.622 0.98
127_Q 216_Y 1.62 0.98
44_V 71_M 1.614 0.98
109_V 139_R 1.6 0.97
103_A 106_E 1.593 0.97
98_M 139_R 1.59 0.97
113_F 193_L 1.565 0.97
117_T 152_A 1.56 0.97
132_N 135_G 1.549 0.97
97_E 190_H 1.547 0.97
162_A 168_A 1.51 0.96
88_L 91_L 1.502 0.96
101_Y 140_Y 1.465 0.95
70_P 79_P 1.459 0.95
111_T 141_L 1.454 0.95
197_L 206_V 1.444 0.95
47_M 67_I 1.435 0.94
110_I 222_M 1.428 0.94
127_Q 130_D 1.421 0.94
142_A 156_M 1.415 0.94
48_K 61_D 1.359 0.92
47_M 59_I 1.348 0.91
169_F 173_M 1.334 0.91
152_A 156_M 1.33 0.91
111_T 139_R 1.321 0.90
22_D 25_I 1.31 0.90
44_V 47_M 1.298 0.89
83_T 86_M 1.293 0.89
21_D 24_A 1.286 0.89
221_E 224_E 1.283 0.89
171_D 175_G 1.268 0.88
75_S 79_P 1.264 0.88
26_Q 30_A 1.264 0.88
145_R 152_A 1.254 0.87
25_I 29_L 1.252 0.87
57_L 66_I 1.196 0.83
64_K 75_S 1.193 0.83
114_T 125_H 1.192 0.83
72_Y 165_K 1.187 0.83
109_V 137_T 1.178 0.82
110_I 205_V 1.175 0.82
157_K 222_M 1.173 0.82
23_A 26_Q 1.162 0.81
116_I 159_I 1.15 0.80
223_K 227_D 1.149 0.80
64_K 73_D 1.141 0.79
220_K 224_E 1.14 0.79
188_A 192_A 1.14 0.79
166_N 182_S 1.139 0.79
160_W 186_D 1.136 0.79
79_P 82_V 1.135 0.79
147_G 150_S 1.132 0.78
214_P 217_Q 1.13 0.78
53_N 164_D 1.123 0.78
146_Q 149_D 1.122 0.78
125_H 140_Y 1.122 0.78
159_I 186_D 1.121 0.77
164_D 168_A 1.12 0.77
71_M 82_V 1.104 0.76
52_T 55_G 1.103 0.76
146_Q 150_S 1.088 0.74
105_Q 133_A 1.08 0.74
136_I 187_I 1.076 0.73
25_I 59_I 1.069 0.73
27_Q 30_A 1.065 0.72
101_Y 128_M 1.062 0.72
117_T 145_R 1.06 0.72
17_F 20_A 1.059 0.72
25_I 64_K 1.053 0.71
39_I 50_V 1.05 0.71
106_E 156_M 1.047 0.70
100_V 137_T 1.047 0.70
213_V 225_F 1.038 0.69
50_V 59_I 1.035 0.69
192_A 196_Q 1.028 0.68
78_A 224_E 1.028 0.68
108_H 223_K 1.026 0.68
30_A 96_K 1.018 0.67
43_P 73_D 1.016 0.67
98_M 141_L 1.015 0.67
134_L 223_K 1.012 0.67
207_L 213_V 1.003 0.66
112_V 124_L 1.001 0.65
92_N 110_I 1.001 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1t3bA10.89411000.322Contact Map0.645
1eejA20.91531000.358Contact Map0.729
1v58A20.89831000.388Contact Map0.562
3tdgA10.90251000.443Contact Map0.499
3gv1A30.597599.90.661Contact Map0.737
3ghaA10.652599.80.72Contact Map0.513
1z6mA10.610299.80.723Contact Map0.543
3f4sA10.67899.80.725Contact Map0.451
3gmfA10.58999.80.725Contact Map0.595
4gxzA40.673799.80.726Contact Map0.662
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0632 seconds.