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OPENSEQ.org

PINQ - Putative DNA-invertase from lambdoid prophage Qin
UniProt: P77170 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13824
Length: 196 (187)
Sequences: 4123
Seq/Len: 22.05

PINQ
Paralog alert: 0.63 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: PINE PINQ PINR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_G 55_R 3.89 1.00
37_I 59_R 3.636 1.00
39_E 52_G 2.902 1.00
56_L 66_L 2.893 1.00
163_R 176_E 2.837 1.00
8_C 21_R 2.496 1.00
124_E 131_R 2.444 1.00
21_R 25_E 2.292 1.00
88_L 93_I 2.215 1.00
112_M 123_F 2.16 1.00
138_R 142_A 2.079 1.00
159_A 163_R 2.049 1.00
97_C 100_L 2.028 1.00
78_A 115_Q 2.017 1.00
171_S 175_R 2.008 1.00
163_R 168_V 1.949 1.00
6_A 24_I 1.946 1.00
122_E 126_D 1.896 1.00
115_Q 119_A 1.887 1.00
111_K 126_D 1.866 1.00
21_R 36_I 1.85 1.00
111_K 122_E 1.814 1.00
12_T 15_Q 1.804 1.00
60_L 66_L 1.801 1.00
79_M 83_K 1.783 1.00
168_V 176_E 1.755 1.00
132_T 136_I 1.75 1.00
5_F 56_L 1.747 1.00
129_L 133_H 1.718 1.00
78_A 118_S 1.712 1.00
21_R 38_E 1.705 1.00
112_M 119_A 1.697 1.00
139_A 144_K 1.668 1.00
53_F 84_T 1.627 1.00
44_S 125_R 1.615 1.00
87_Q 91_T 1.613 1.00
22_R 26_S 1.602 1.00
35_Q 55_R 1.589 1.00
174_A 184_I 1.542 1.00
81_I 118_S 1.51 1.00
60_L 93_I 1.51 1.00
78_A 82_R 1.475 1.00
125_R 128_L 1.464 1.00
89_T 111_K 1.46 1.00
82_R 115_Q 1.415 1.00
181_R 185_L 1.403 0.99
137_V 141_G 1.386 0.99
10_I 15_Q 1.383 0.99
4_I 29_F 1.378 0.99
5_F 59_R 1.366 0.99
79_M 86_E 1.344 0.99
153_N 156_Q 1.332 0.99
72_D 121_A 1.309 0.99
164_I 173_I 1.307 0.99
107_S 110_G 1.286 0.99
135_G 139_A 1.276 0.99
25_E 36_I 1.259 0.99
86_E 90_E 1.248 0.99
171_S 181_R 1.232 0.98
168_V 172_A 1.229 0.98
85_V 114_M 1.219 0.98
169_S 172_A 1.209 0.98
49_E 54_N 1.208 0.98
162_E 166_S 1.207 0.98
68_V 95_V 1.203 0.98
184_I 187_A 1.194 0.98
185_L 189_A 1.175 0.98
6_A 36_I 1.161 0.97
41_I 51_P 1.152 0.97
24_I 67_I 1.146 0.97
8_C 17_T 1.144 0.97
69_T 134_S 1.142 0.97
133_H 136_I 1.139 0.97
68_V 97_C 1.131 0.97
75_G 81_I 1.126 0.97
164_I 188_K 1.104 0.96
136_I 146_F 1.097 0.96
163_R 166_S 1.084 0.96
65_Q 96_H 1.08 0.95
37_I 56_L 1.079 0.95
127_L 131_R 1.074 0.95
53_F 56_L 1.072 0.95
136_I 140_R 1.072 0.95
160_V 184_I 1.07 0.95
163_R 173_I 1.068 0.95
138_R 141_G 1.041 0.94
112_M 116_V 1.028 0.94
112_M 120_V 1.027 0.94
66_L 88_L 1.026 0.94
55_R 59_R 1.006 0.93
160_V 173_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gdtA20.93371000.143Contact Map0.657
3uj3X10.95411000.161Contact Map0.418
2r0qC40.95921000.182Contact Map0.662
4bqqA20.96941000.278Contact Map0.671
3g13A20.78061000.343Contact Map0.576
3guvA10.76531000.355Contact Map0.54
2gm5A40.70921000.372Contact Map0.85
3lhkA40.734799.90.46Contact Map0.64
3bvpA20.632799.90.462Contact Map0.636
3ilxA20.663399.90.462Contact Map0.622

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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