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OPENSEQ.org
YFEX - Probable deferrochelatase/peroxidase YfeX
UniProt: P76536 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14165
Length: 299 (297)
Sequences: 829
Seq/Len: 2.79
YFEX
Paralog alert: 0.45 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EFEB YFEX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_A 290_A 2.975 1.00
100_S 106_N 2.941 1.00
262_L 265_M 2.868 1.00
230_I 261_Q 2.457 1.00
22_N 124_K 2.362 1.00
21_A 114_M 2.362 1.00
117_F 121_I 2.36 1.00
214_S 217_T 2.302 1.00
75_E 254_R 2.23 1.00
30_L 63_T 2.22 1.00
173_V 247_Y 2.201 1.00
91_Q 288_Y 2.196 1.00
169_S 251_Y 2.179 1.00
95_L 171_V 2.169 1.00
191_Q 199_K 2.131 1.00
69_G 164_V 2.099 1.00
6_S 45_E 2.091 1.00
23_V 63_T 2.062 1.00
98_I 106_N 2.059 1.00
8_I 290_A 1.994 1.00
139_S 276_M 1.98 0.99
59_F 291_P 1.932 0.99
173_V 249_C 1.92 0.99
92_F 288_Y 1.891 0.99
20_E 92_F 1.812 0.99
47_K 204_E 1.792 0.99
198_T 201_A 1.783 0.99
21_A 96_I 1.755 0.99
26_E 29_A 1.731 0.98
21_A 121_I 1.695 0.98
255_L 287_Y 1.686 0.98
275_A 278_R 1.683 0.98
61_N 72_G 1.66 0.98
65_R 72_G 1.64 0.97
179_N 182_Q 1.623 0.97
165_D 289_F 1.56 0.96
34_S 59_F 1.55 0.96
257_N 265_M 1.545 0.96
61_N 65_R 1.502 0.95
21_A 123_V 1.499 0.95
139_S 178_H 1.491 0.95
186_M 190_D 1.468 0.94
77_K 259_E 1.467 0.94
77_K 256_H 1.464 0.94
204_E 265_M 1.447 0.94
115_E 184_N 1.436 0.93
234_S 250_A 1.432 0.93
164_V 208_D 1.431 0.93
277_L 280_T 1.426 0.93
111_Q 184_N 1.415 0.93
79_F 82_Y 1.415 0.93
52_H 101_L 1.406 0.92
83_G 266_F 1.401 0.92
175_R 283_V 1.397 0.92
204_E 262_L 1.393 0.92
98_I 110_A 1.39 0.92
276_M 280_T 1.39 0.92
141_F 192_E 1.355 0.90
252_C 265_M 1.351 0.90
219_V 265_M 1.312 0.88
189_H 193_M 1.297 0.88
158_A 231_V 1.291 0.87
95_L 251_Y 1.286 0.87
40_K 116_A 1.274 0.86
134_E 145_T 1.27 0.86
85_G 281_K 1.253 0.85
262_L 266_F 1.248 0.85
19_I 123_V 1.246 0.85
75_E 170_Y 1.246 0.85
198_T 205_I 1.231 0.84
188_V 279_F 1.219 0.83
187_S 190_D 1.211 0.82
222_K 226_K 1.197 0.81
142_V 202_N 1.195 0.81
99_L 235_L 1.195 0.81
155_R 159_V 1.192 0.81
36_T 116_A 1.188 0.81
127_I 239_T 1.187 0.81
97_H 251_Y 1.185 0.80
69_G 242_G 1.185 0.80
211_P 275_A 1.173 0.79
32_A 36_T 1.168 0.79
257_N 261_Q 1.164 0.79
26_E 32_A 1.159 0.78
38_A 297_M 1.145 0.77
194_V 281_K 1.138 0.77
20_E 91_Q 1.138 0.77
148_P 250_A 1.135 0.76
190_D 193_M 1.133 0.76
213_T 218_R 1.118 0.75
213_T 217_T 1.117 0.75
41_L 57_V 1.113 0.74
214_S 220_D 1.109 0.74
28_D 151_E 1.105 0.74
205_I 210_R 1.102 0.73
230_I 248_F 1.098 0.73
261_Q 265_M 1.098 0.73
186_M 194_V 1.095 0.73
234_S 246_L 1.094 0.72
170_Y 191_Q 1.082 0.71
177_E 243_T 1.082 0.71
171_V 249_C 1.078 0.71
257_N 262_L 1.077 0.71
84_K 204_E 1.077 0.71
90_T 288_Y 1.071 0.70
205_I 262_L 1.062 0.69
51_A 105_V 1.06 0.69
63_T 68_S 1.058 0.69
20_E 288_Y 1.057 0.69
228_L 261_Q 1.057 0.69
187_S 199_K 1.054 0.68
7_G 56_V 1.053 0.68
203_E 293_L 1.049 0.68
16_A 95_L 1.047 0.68
193_M 205_I 1.041 0.67
220_D 227_G 1.04 0.67
237_Y 280_T 1.039 0.67
16_A 234_S 1.033 0.66
285_G 289_F 1.032 0.66
204_E 261_Q 1.028 0.66
208_D 242_G 1.027 0.65
259_E 265_M 1.02 0.65
204_E 266_F 1.017 0.64
251_Y 283_V 1.016 0.64
176_W 183_L 1.016 0.64
187_S 194_V 1.015 0.64
177_E 237_Y 1.009 0.63
205_I 265_M 1.007 0.63
7_G 97_H 1.005 0.63
84_K 163_G 1.005 0.63
79_F 87_A 1.005 0.63
164_V 242_G 1.002 0.63
37_F 117_F 1.002 0.63
18_W 130_F 1 0.62
92_F 100_S 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iizA10.99331000.106Contact Map0.581
3qnsA10.99671000.124Contact Map0.586
4gu7A40.99671000.128Contact Map0.598
2gvkA10.991000.13Contact Map0.599
4grcA10.97661000.166Contact Map0.633
4gs1A20.97991000.177Contact Map0.692
3o72A40.97991000.178Contact Map0.678
4gt2B40.97991000.182Contact Map0.687
4g2cA20.99671000.328Contact Map0.47
3vxjA10.991000.345Contact Map0.484
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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