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OPENSEQ.org
EFEB - Deferrochelatase/peroxidase EfeB
UniProt: P31545 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11735
Length: 423 (411)
Sequences: 520
Seq/Len: 1.27
EFEB
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EFEB YFEX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
414_D 418_S 3.501 1.00
345_M 382_V 3.318 1.00
78_D 207_R 3.072 1.00
62_A 102_T 2.647 1.00
418_S 422_R 2.503 1.00
268_S 371_Y 2.494 1.00
136_L 416_F 2.492 1.00
87_L 142_L 2.43 0.99
200_T 204_L 2.322 0.99
77_F 197_I 2.306 0.99
415_Y 422_R 2.281 0.99
57_Y 99_A 2.248 0.99
328_S 331_R 2.127 0.98
138_V 417_G 1.996 0.97
138_V 406_L 1.96 0.97
307_Q 311_D 1.869 0.95
383_Q 386_L 1.851 0.95
305_G 323_V 1.845 0.95
175_G 403_F 1.794 0.94
54_Q 62_A 1.788 0.94
318_D 321_G 1.75 0.93
79_V 142_L 1.735 0.92
264_T 404_F 1.7 0.91
54_Q 131_N 1.693 0.91
178_L 270_Q 1.631 0.89
77_F 179_L 1.592 0.87
131_N 184_N 1.582 0.87
372_Q 386_L 1.574 0.86
182_C 350_Y 1.56 0.86
378_G 382_V 1.556 0.86
231_L 277_F 1.553 0.85
343_S 382_V 1.551 0.85
76_A 175_G 1.521 0.84
183_A 189_V 1.515 0.83
313_P 330_I 1.511 0.83
414_D 419_A 1.503 0.83
305_G 311_D 1.478 0.81
319_P 331_R 1.475 0.81
413_N 418_S 1.443 0.79
97_R 199_H 1.429 0.78
79_V 87_L 1.424 0.78
411_D 414_D 1.422 0.78
83_D 86_D 1.419 0.78
79_V 147_F 1.411 0.77
270_Q 369_V 1.403 0.76
272_V 369_V 1.389 0.75
333_A 383_Q 1.389 0.75
333_A 386_L 1.387 0.75
186_Q 270_Q 1.364 0.74
297_D 300_T 1.354 0.73
392_E 395_V 1.351 0.73
173_C 403_F 1.35 0.72
15_R 18_L 1.349 0.72
75_V 206_V 1.344 0.72
95_T 416_F 1.342 0.72
236_G 366_L 1.333 0.71
98_F 136_L 1.33 0.71
226_T 237_T 1.324 0.70
72_M 367_L 1.323 0.70
308_H 311_D 1.321 0.70
411_D 418_S 1.321 0.70
304_L 324_I 1.314 0.70
272_V 367_L 1.306 0.69
174_H 403_F 1.304 0.69
163_F 383_Q 1.302 0.68
17_L 32_V 1.297 0.68
64_I 405_A 1.295 0.68
14_R 18_L 1.29 0.67
27_A 32_V 1.283 0.67
278_R 396_K 1.282 0.67
292_T 325_A 1.282 0.67
165_N 397_P 1.28 0.67
274_L 398_I 1.279 0.66
406_L 416_F 1.277 0.66
60_H 266_G 1.267 0.65
380_L 402_Y 1.263 0.65
24_L 32_V 1.262 0.65
231_L 328_S 1.258 0.65
308_H 412_A 1.257 0.65
419_A 422_R 1.256 0.64
26_L 345_M 1.255 0.64
167_S 396_K 1.253 0.64
76_A 403_F 1.241 0.63
164_P 387_N 1.236 0.63
259_Q 373_H 1.232 0.62
91_F 138_V 1.226 0.62
91_F 421_L 1.223 0.61
415_Y 418_S 1.216 0.61
240_P 370_C 1.214 0.61
116_P 284_R 1.206 0.60
229_N 277_F 1.205 0.60
135_T 182_C 1.201 0.59
66_T 135_T 1.194 0.59
99_A 413_N 1.19 0.58
160_M 163_F 1.186 0.58
254_V 269_Y 1.181 0.57
134_I 196_I 1.179 0.57
315_Y 330_I 1.179 0.57
252_V 345_M 1.178 0.57
63_G 180_Q 1.177 0.57
391_L 395_V 1.163 0.56
89_R 93_L 1.159 0.55
32_V 39_Q 1.155 0.55
64_I 310_H 1.155 0.55
58_G 408_G 1.151 0.54
290_Q 298_K 1.15 0.54
375_L 402_Y 1.148 0.54
63_G 133_T 1.145 0.54
55_P 102_T 1.145 0.54
238_A 312_V 1.144 0.54
345_M 386_L 1.143 0.54
69_Q 184_N 1.139 0.53
278_R 281_F 1.138 0.53
31_P 47_P 1.133 0.53
156_K 374_D 1.132 0.53
172_L 274_L 1.131 0.52
254_V 264_T 1.129 0.52
231_L 391_L 1.128 0.52
89_R 328_S 1.127 0.52
72_M 349_G 1.126 0.52
227_P 234_K 1.118 0.51
16_R 23_A 1.116 0.51
372_Q 395_V 1.115 0.51
300_T 308_H 1.115 0.51
136_L 345_M 1.113 0.51
287_L 394_Y 1.113 0.51
88_E 421_L 1.113 0.51
14_R 17_L 1.112 0.51
252_V 399_G 1.11 0.50
285_T 289_E 1.108 0.50
117_P 121_G 1.107 0.50
140_H 153_M 1.107 0.50
345_M 378_G 1.101 0.50
119_D 191_H 1.1 0.49
132_L 372_Q 1.1 0.49
32_V 40_S 1.1 0.49
298_K 378_G 1.096 0.49
66_T 180_Q 1.091 0.49
372_Q 378_G 1.09 0.48
55_P 103_Q 1.088 0.48
313_P 334_N 1.086 0.48
33_A 37_K 1.085 0.48
238_A 313_P 1.084 0.48
53_K 411_D 1.068 0.46
210_R 354_L 1.063 0.46
331_R 403_F 1.06 0.45
226_T 310_H 1.056 0.45
289_E 393_E 1.054 0.45
124_G 223_G 1.054 0.45
135_T 350_Y 1.053 0.45
213_F 226_T 1.053 0.45
354_L 417_G 1.049 0.44
39_Q 42_P 1.047 0.44
230_L 277_F 1.042 0.44
297_D 306_M 1.039 0.43
47_P 50_R 1.038 0.43
213_F 230_L 1.037 0.43
133_T 180_Q 1.035 0.43
37_K 43_G 1.034 0.43
95_T 409_V 1.034 0.43
59_E 266_G 1.033 0.43
39_Q 43_G 1.033 0.43
23_A 27_A 1.032 0.43
40_S 45_L 1.031 0.43
108_P 123_L 1.03 0.43
313_P 324_I 1.03 0.43
233_F 294_F 1.029 0.42
63_G 350_Y 1.029 0.42
64_I 268_S 1.029 0.42
63_G 228_I 1.024 0.42
76_A 174_H 1.023 0.42
160_M 315_Y 1.021 0.42
325_A 390_A 1.021 0.42
159_K 328_S 1.02 0.42
42_P 47_P 1.018 0.41
66_T 69_Q 1.018 0.41
63_G 182_C 1.017 0.41
72_M 350_Y 1.017 0.41
16_R 19_K 1.015 0.41
88_E 92_R 1.014 0.41
227_P 349_G 1.014 0.41
43_G 47_P 1.014 0.41
99_A 411_D 1.013 0.41
325_A 330_I 1.01 0.41
349_G 370_C 1.009 0.41
23_A 43_G 1.008 0.40
135_T 180_Q 1.007 0.40
294_F 307_Q 1.007 0.40
204_L 413_N 1.006 0.40
181_I 189_V 1.004 0.40
175_G 283_D 1.003 0.40
40_S 43_G 1.001 0.40
294_F 328_S 1.001 0.40
26_L 30_C 1.001 0.40
166_D 392_E 1 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4grcA10.96931000.169Contact Map0.611
4gt2B40.96221000.189Contact Map0.663
3o72A40.91731000.193Contact Map0.648
4gs1A20.89361000.244Contact Map0.611
2gvkA10.72811000.366Contact Map0.501
4g2cA20.91021000.38Contact Map0.467
3vxjA10.80141000.384Contact Map0.419
2iizA10.7211000.387Contact Map0.498
4au9A20.79671000.391Contact Map0.457
3qnsA10.74231000.4Contact Map0.488
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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