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YFDE - Uncharacterized protein YfdE
UniProt: P76518 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13284
Length: 381 (372)
Sequences: 4572
Seq/Len: 12.29
YFDE
Paralog alert: 0.70 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: CAIB FCTA YFDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_R 72_E 4.318 1.00
112_S 115_T 4.03 1.00
28_T 98_A 3.566 1.00
301_Q 305_V 3.242 1.00
80_N 83_D 3.102 1.00
88_I 119_I 2.963 1.00
107_E 112_S 2.881 1.00
126_A 184_I 2.84 1.00
116_L 123_L 2.822 1.00
126_A 180_L 2.752 1.00
189_Y 192_E 2.732 1.00
245_Q 302_A 2.659 1.00
92_K 119_I 2.584 1.00
84_K 88_I 2.565 1.00
302_A 305_V 2.559 1.00
76_L 87_F 2.525 1.00
244_T 303_A 2.51 1.00
301_Q 306_W 2.488 1.00
369_D 372_G 2.403 1.00
243_N 299_K 2.361 1.00
16_I 91_L 2.352 1.00
371_H 374_Q 2.348 1.00
190_G 198_A 2.314 1.00
297_T 300_T 2.249 1.00
113_W 117_Q 2.246 1.00
14_L 93_Q 2.24 1.00
117_Q 196_R 2.227 1.00
301_Q 309_R 2.226 1.00
286_N 289_I 2.189 1.00
14_L 37_R 2.178 1.00
372_G 376_R 2.156 1.00
18_M 87_F 2.123 1.00
16_I 94_A 2.09 1.00
96_V 184_I 2.067 1.00
97_L 123_L 2.038 1.00
85_S 89_N 2.032 1.00
133_H 201_D 2.028 1.00
89_N 92_K 2.004 1.00
34_M 186_S 1.984 1.00
190_G 355_G 1.976 1.00
81_D 84_K 1.958 1.00
292_Q 296_R 1.954 1.00
137_L 329_L 1.927 1.00
182_S 185_V 1.92 1.00
106_M 111_F 1.898 1.00
304_E 308_A 1.892 1.00
190_G 194_S 1.883 1.00
74_V 375_I 1.877 1.00
293_Y 296_R 1.876 1.00
190_G 196_R 1.861 1.00
32_C 70_G 1.838 1.00
294_I 298_L 1.826 1.00
322_S 325_E 1.822 1.00
198_A 354_S 1.808 1.00
17_D 28_T 1.793 1.00
76_L 83_D 1.762 1.00
367_T 370_Q 1.753 1.00
340_E 343_G 1.751 1.00
183_G 200_V 1.748 1.00
268_L 271_L 1.733 1.00
13_L 188_L 1.729 1.00
72_E 378_E 1.726 1.00
196_R 355_G 1.718 1.00
140_A 311_H 1.716 1.00
124_I 191_R 1.689 1.00
159_Y 162_A 1.679 1.00
74_V 372_G 1.676 1.00
127_S 199_H 1.642 1.00
137_L 140_A 1.637 1.00
72_E 374_Q 1.618 1.00
205_F 332_T 1.605 1.00
151_S 208_T 1.605 1.00
262_L 266_L 1.605 1.00
91_L 120_N 1.579 1.00
206_D 335_R 1.578 1.00
289_I 292_Q 1.576 1.00
172_A 208_T 1.576 1.00
268_L 297_T 1.572 1.00
279_S 282_L 1.546 1.00
276_R 289_I 1.541 1.00
264_Q 272_V 1.54 1.00
115_T 118_E 1.539 1.00
240_D 291_K 1.532 1.00
76_L 86_I 1.524 1.00
308_A 312_E 1.508 1.00
340_E 345_M 1.506 1.00
91_L 116_L 1.505 1.00
142_A 204_M 1.504 1.00
149_A 250_T 1.5 1.00
198_A 357_A 1.5 1.00
33_N 69_H 1.491 1.00
77_D 80_N 1.481 1.00
268_L 293_Y 1.467 1.00
244_T 249_I 1.447 1.00
298_L 306_W 1.447 1.00
324_A 328_K 1.444 1.00
297_T 306_W 1.444 1.00
264_Q 269_T 1.437 1.00
328_K 333_Q 1.432 1.00
303_A 325_E 1.43 1.00
265_A 309_R 1.419 1.00
331_Q 334_A 1.419 1.00
242_F 291_K 1.415 1.00
13_L 189_Y 1.415 1.00
91_L 119_I 1.395 0.99
189_Y 193_K 1.377 0.99
113_W 125_Y 1.358 0.99
18_M 97_L 1.345 0.99
243_N 295_E 1.337 0.99
96_V 124_I 1.329 0.99
83_D 376_R 1.326 0.99
88_I 111_F 1.323 0.99
305_V 309_R 1.322 0.99
278_S 282_L 1.319 0.99
265_A 313_V 1.303 0.99
366_A 371_H 1.303 0.99
128_S 180_L 1.297 0.99
183_G 351_I 1.29 0.99
99_E 127_S 1.284 0.99
194_S 355_G 1.281 0.99
48_D 51_R 1.279 0.99
78_L 109_L 1.279 0.99
188_L 192_E 1.265 0.99
175_C 211_F 1.258 0.99
27_G 181_F 1.251 0.99
243_N 298_L 1.245 0.98
122_R 192_E 1.238 0.98
282_L 285_Q 1.233 0.98
276_R 286_N 1.226 0.98
303_A 319_P 1.226 0.98
373_E 377_Q 1.224 0.98
122_R 191_R 1.216 0.98
18_M 106_M 1.214 0.98
203_A 206_D 1.209 0.98
364_G 370_Q 1.206 0.98
137_L 150_M 1.204 0.98
354_S 357_A 1.2 0.98
321_L 325_E 1.199 0.98
271_L 293_Y 1.199 0.98
277_F 286_N 1.198 0.98
161_D 228_R 1.193 0.98
82_H 85_S 1.188 0.98
105_T 108_K 1.182 0.98
15_V 96_V 1.179 0.98
261_A 264_Q 1.176 0.98
8_G 11_E 1.163 0.97
149_A 318_A 1.156 0.97
79_K 109_L 1.145 0.97
73_S 366_A 1.14 0.97
209_L 326_A 1.138 0.97
249_I 298_L 1.131 0.97
113_W 199_H 1.128 0.97
366_A 370_Q 1.128 0.97
305_V 308_A 1.126 0.97
41_V 74_V 1.126 0.97
260_S 264_Q 1.12 0.96
47_G 51_R 1.119 0.96
70_G 362_M 1.117 0.96
74_V 86_I 1.108 0.96
188_L 191_R 1.106 0.96
87_F 111_F 1.106 0.96
144_D 148_Q 1.096 0.96
9_P 353_I 1.094 0.96
249_I 306_W 1.091 0.96
86_I 376_R 1.09 0.96
262_L 294_I 1.085 0.96
131_F 150_M 1.084 0.96
185_V 189_Y 1.082 0.96
150_M 329_L 1.077 0.95
259_F 263_C 1.071 0.95
209_L 332_T 1.07 0.95
136_P 334_A 1.057 0.95
269_T 272_V 1.054 0.95
201_D 335_R 1.036 0.94
280_N 284_V 1.032 0.94
260_S 273_N 1.026 0.94
75_V 372_G 1.026 0.94
90_M 379_F 1.025 0.93
179_Y 210_S 1.024 0.93
87_F 91_L 1.016 0.93
16_I 87_F 1.015 0.93
88_I 92_K 1.014 0.93
266_L 297_T 1.012 0.93
88_I 115_T 1.007 0.93
255_N 258_L 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hl6A60.9974100-0.024Contact Map0.864
4ed9A10.9843100-0.002Contact Map0.753
1q7eA10.98691000.001Contact Map0.742
2vjqA40.98161000.008Contact Map0.814
3ubmA40.99211000.01Contact Map0.794
1xk7A30.97641000.014Contact Map0.77
2yimA40.93441000.061Contact Map0.744
2g04A60.92911000.091Contact Map0.759
2a9fA20.535484.30.956Contact Map0.285
1vl6A40.540783.60.956Contact Map0.48
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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