May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
FCTA - Formyl-coenzyme A transferase
UniProt: P69902 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14145
Length: 416 (392)
Sequences: 4586
Seq/Len: 11.70
FCTA
Paralog alert: 0.70 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: CAIB FCTA YFDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_D 68_R 4.31 1.00
108_T 111_H 3.985 1.00
23_T 94_V 3.452 1.00
319_I 323_E 3.165 1.00
76_T 79_G 2.933 1.00
103_D 108_T 2.928 1.00
84_E 115_I 2.902 1.00
112_I 119_L 2.818 1.00
122_G 180_L 2.771 1.00
122_G 176_L 2.751 1.00
394_A 411_K 2.72 1.00
185_L 188_E 2.695 1.00
403_S 406_E 2.598 1.00
320_D 323_E 2.566 1.00
88_R 115_I 2.562 1.00
72_L 83_M 2.549 1.00
263_D 320_D 2.541 1.00
80_K 84_E 2.492 1.00
262_T 321_K 2.485 1.00
319_I 324_A 2.413 1.00
11_L 87_I 2.278 1.00
390_G 393_T 2.263 1.00
392_H 395_A 2.256 1.00
261_E 317_V 2.244 1.00
315_Y 318_T 2.218 1.00
113_Q 192_R 2.189 1.00
186_H 194_Q 2.185 1.00
358_E 366_K 2.178 1.00
9_K 89_E 2.166 1.00
319_I 327_Y 2.161 1.00
398_Q 404_D 2.16 1.00
304_H 307_D 2.155 1.00
109_W 113_Q 2.129 1.00
85_K 406_E 2.123 1.00
82_V 402_Y 2.093 1.00
9_K 32_D 2.076 1.00
13_F 83_M 2.06 1.00
186_H 378_A 2.057 1.00
92_I 180_L 2.041 1.00
78_E 413_N 2.025 1.00
11_L 90_A 2.024 1.00
93_L 119_L 2.004 1.00
81_E 85_K 1.972 1.00
70_I 396_V 1.965 1.00
129_E 197_T 1.959 1.00
29_F 182_A 1.954 1.00
85_K 88_R 1.926 1.00
310_A 314_K 1.926 1.00
77_A 80_K 1.914 1.00
178_I 181_L 1.889 1.00
133_Y 347_D 1.869 1.00
102_I 107_F 1.868 1.00
393_T 397_L 1.864 1.00
312_I 316_T 1.855 1.00
322_H 326_A 1.843 1.00
194_Q 377_S 1.839 1.00
186_H 190_T 1.839 1.00
186_H 192_R 1.816 1.00
68_R 399_E 1.812 1.00
340_S 343_E 1.802 1.00
27_A 66_N 1.788 1.00
12_D 23_T 1.751 1.00
179_G 196_V 1.739 1.00
8_I 184_L 1.723 1.00
311_E 314_K 1.712 1.00
70_I 393_T 1.707 1.00
388_L 391_E 1.697 1.00
394_A 408_A 1.686 1.00
286_K 289_W 1.685 1.00
136_V 329_T 1.67 1.00
155_F 158_G 1.67 1.00
120_I 187_R 1.661 1.00
68_R 395_A 1.655 1.00
409_A 413_N 1.644 1.00
147_G 204_V 1.627 1.00
133_Y 136_V 1.623 1.00
192_R 378_A 1.622 1.00
123_S 195_R 1.606 1.00
87_I 116_N 1.599 1.00
72_L 79_G 1.594 1.00
280_T 284_I 1.593 1.00
294_A 307_D 1.591 1.00
282_K 290_I 1.583 1.00
202_D 353_S 1.568 1.00
406_E 409_A 1.562 1.00
201_Q 350_L 1.553 1.00
286_K 315_Y 1.547 1.00
358_E 368_L 1.539 1.00
73_N 76_T 1.537 1.00
194_Q 379_F 1.537 1.00
111_H 114_E 1.535 1.00
360_E 366_K 1.516 1.00
326_A 330_Q 1.513 1.00
297_T 300_A 1.51 1.00
168_G 204_V 1.492 1.00
138_A 200_M 1.457 1.00
346_L 351_R 1.457 1.00
258_K 309_F 1.452 1.00
307_D 310_A 1.429 1.00
72_L 82_V 1.429 1.00
408_A 412_Q 1.424 1.00
28_W 65_S 1.417 1.00
87_I 112_I 1.413 1.00
282_K 287_P 1.41 1.00
286_K 311_E 1.405 0.99
315_Y 324_A 1.404 0.99
262_T 268_I 1.403 0.99
316_T 324_A 1.392 0.99
342_K 346_L 1.39 0.99
321_K 343_E 1.383 0.99
349_S 352_Q 1.38 0.99
145_A 269_Y 1.364 0.99
8_I 185_L 1.363 0.99
283_A 327_Y 1.362 0.99
260_W 309_F 1.362 0.99
87_I 115_I 1.354 0.99
185_L 189_K 1.346 0.99
261_E 313_E 1.325 0.99
179_G 374_M 1.319 0.99
43_D 46_R 1.318 0.99
190_T 378_A 1.307 0.99
402_Y 407_I 1.301 0.99
387_P 392_H 1.299 0.99
13_F 93_L 1.299 0.99
84_E 107_F 1.29 0.99
109_W 121_F 1.272 0.99
323_E 327_Y 1.268 0.99
124_I 176_L 1.267 0.99
92_I 120_I 1.26 0.99
261_E 316_T 1.258 0.99
95_E 123_S 1.245 0.98
184_L 188_E 1.244 0.98
13_F 102_I 1.243 0.98
294_A 304_H 1.234 0.98
295_Y 304_H 1.233 0.98
22_C 177_L 1.231 0.98
296_S 300_A 1.225 0.98
283_A 331_F 1.223 0.98
385_A 391_E 1.22 0.98
78_E 81_E 1.215 0.98
339_L 343_E 1.208 0.98
199_S 202_D 1.203 0.98
171_N 207_L 1.198 0.98
74_T 105_M 1.192 0.98
394_A 398_Q 1.191 0.98
289_W 311_E 1.191 0.98
300_A 303_P 1.188 0.98
118_R 188_E 1.183 0.98
321_K 337_P 1.181 0.98
280_T 312_I 1.161 0.97
85_K 402_Y 1.159 0.97
118_R 187_R 1.155 0.97
387_P 391_E 1.154 0.97
10_V 92_I 1.148 0.97
133_Y 146_A 1.147 0.97
268_I 316_T 1.145 0.97
66_N 384_K 1.14 0.97
205_L 344_I 1.137 0.97
145_A 336_A 1.132 0.97
127_F 146_A 1.129 0.97
69_S 387_P 1.127 0.97
323_E 326_A 1.125 0.97
42_G 46_R 1.122 0.97
411_K 416_I 1.119 0.96
101_A 104_H 1.109 0.96
279_N 282_K 1.108 0.96
82_V 415_A 1.108 0.96
83_M 107_F 1.103 0.96
3_T 6_Q 1.091 0.96
268_I 324_A 1.083 0.96
157_D 241_R 1.081 0.95
4_P 376_F 1.076 0.95
109_W 195_R 1.066 0.95
36_I 70_I 1.061 0.95
205_L 350_L 1.061 0.95
278_E 282_K 1.06 0.95
140_E 144_Q 1.06 0.95
75_K 105_M 1.058 0.95
181_L 185_L 1.058 0.95
146_A 347_D 1.049 0.94
132_P 352_Q 1.047 0.94
277_W 281_C 1.042 0.94
197_T 353_S 1.041 0.94
278_E 291_T 1.038 0.94
184_L 187_R 1.025 0.93
84_E 88_R 1.022 0.93
361_Q 365_G 1.011 0.93
298_A 302_Q 1.009 0.93
71_E 393_T 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q7eA10.98321000.016Contact Map0.735
2vjqA40.94231000.019Contact Map0.816
3ubmA40.98081000.026Contact Map0.79
1xk7A30.92311000.042Contact Map0.761
4ed9A10.89421000.071Contact Map0.761
4hl6A60.89421000.072Contact Map0.863
2yimA40.85581000.123Contact Map0.753
2g04A60.84621000.157Contact Map0.766
2a9fA20.478472.50.963Contact Map0.286
1vl6A40.447168.80.964Contact Map0.413
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0302 seconds.