OPENSEQ.org - YFCQ - ECOLI GREMLIN

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YFCQ - Uncharacterized fimbrial-like protein YfcQ

UniProt:	P76500	Sequence MRKTFLTLLCVSSAIAHAADEDITFHGTLLSPPTCSISGGKTIEVEFRDLIIDDINGNYGRKEVPYELTCDSTTRHPDWEMTLTWTGTQTSFNDAAIETDVPGFGIELQHDGQRFKLNTPLAINATDFTQKPKLEAVPVKASDAVLSDTNFSAYATLRVDYQ	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG14120
Length:	162 (159)
Sequences:	220
Seq/Len:	1.38

YFCQ
Paralog alert: 0.80 [within 20: 0.35] - ratio of genomes with paralogs
Cluster includes: YFCQ YFCR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
25_F	29_L	2.946	1.00
83_L	157_L	2.577	1.00
103_G	141_A	2.068	0.98
52_I	55_I	2.035	0.98
57_G	138_P	1.884	0.96
57_G	137_V	1.837	0.96
56_N	138_P	1.815	0.95
93_N	104_F	1.785	0.95
66_Y	132_P	1.69	0.92
137_V	146_L	1.66	0.91
45_V	48_R	1.651	0.91
90_T	105_G	1.639	0.91
106_I	138_P	1.634	0.90
51_I	54_D	1.623	0.90
58_N	138_P	1.554	0.87
88_T	153_A	1.518	0.85
33_P	146_L	1.486	0.84
135_E	157_L	1.47	0.83
55_I	137_V	1.453	0.82
68_L	93_N	1.4	0.78
34_T	85_W	1.35	0.75
40_G	44_E	1.345	0.74
108_L	155_A	1.308	0.71
61_R	109_Q	1.305	0.71
50_L	62_K	1.291	0.70
106_I	136_A	1.28	0.69
29_L	90_T	1.263	0.68
61_R	135_E	1.26	0.67
5_F	8_L	1.253	0.67
11_V	14_A	1.252	0.67
117_L	155_A	1.246	0.66
36_S	49_D	1.239	0.65
25_F	84_T	1.209	0.63
22_D	143_D	1.203	0.62
3_K	10_C	1.193	0.61
57_G	140_K	1.185	0.60
79_W	123_I	1.181	0.60
84_T	120_P	1.179	0.60
32_P	64_V	1.176	0.59
55_I	97_I	1.175	0.59
55_I	146_L	1.165	0.58
37_I	50_L	1.161	0.58
3_K	7_T	1.161	0.58
64_V	108_L	1.157	0.58
65_P	104_F	1.141	0.56
25_F	30_L	1.136	0.55
3_K	9_L	1.127	0.55
29_L	153_A	1.121	0.54
64_V	134_L	1.116	0.53
112_G	148_D	1.111	0.53
72_S	83_L	1.11	0.53
4_T	8_L	1.108	0.53
103_G	139_V	1.107	0.53
59_Y	138_P	1.106	0.52
5_F	10_C	1.102	0.52
104_F	112_G	1.099	0.52
30_L	66_Y	1.094	0.51
99_T	156_T	1.092	0.51
66_Y	160_D	1.085	0.50
65_P	71_D	1.081	0.50
1_M	4_T	1.075	0.49
99_T	112_G	1.066	0.48
3_K	8_L	1.059	0.48
4_T	14_A	1.052	0.47
96_A	107_E	1.049	0.47
8_L	16_A	1.049	0.47
50_L	106_I	1.036	0.45
54_D	92_F	1.035	0.45
60_G	125_A	1.034	0.45
51_I	159_V	1.034	0.45
100_D	104_F	1.032	0.45
62_K	74_T	1.028	0.45
123_I	131_K	1.02	0.44
6_L	10_C	1.01	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1n12A	2	0.7531	100	0.386	Contact Map	0.262
2w07B	1	0.8519	99.9	0.58	Contact Map	0.203
2xg5B	1	0.9815	99.8	0.633	Contact Map	0.27
2jtyA	1	0.8827	99.7	0.643	Contact Map	0.245
2uy6B	2	0.9074	99.7	0.649	Contact Map	0.25
2jmrA	1	0.858	99.7	0.651	Contact Map	0.185
1pdkB	1	0.8457	99.7	0.654	Contact Map	0.29
4dwhB	2	0.784	99.6	0.689	Contact Map	0.337
3bwuF	1	0.7778	99.6	0.69	Contact Map	0.378
3jwnH	2	0.9074	99.5	0.691	Contact Map	0.286

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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