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RHMA - 2-keto-3-deoxy-L-rhamnonate aldolase
UniProt: P76469 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14083
Length: 267 (251)
Sequences: 1030
Seq/Len: 4.10
RHMA
Paralog alert: 0.57 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GARL RHMA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_T 160_N 3.321 1.00
149_L 172_G 3.059 1.00
165_L 173_V 2.8 1.00
102_A 106_R 2.776 1.00
162_D 205_R 2.646 1.00
12_R 17_E 2.579 1.00
161_L 205_R 2.479 1.00
201_T 205_R 2.434 1.00
21_G 42_W 2.334 1.00
75_P 86_V 2.29 1.00
103_E 106_R 2.281 1.00
158_L 198_I 2.28 1.00
150_V 170_I 2.271 1.00
78_G 108_V 2.227 1.00
160_N 163_E 2.068 1.00
200_E 229_W 2.03 1.00
101_T 156_T 1.989 1.00
100_D 104_Q 1.969 1.00
162_D 209_A 1.952 1.00
112_T 148_L 1.873 1.00
32_A 64_V 1.852 1.00
70_Q 92_Q 1.842 1.00
189_N 192_H 1.841 1.00
158_L 161_L 1.796 1.00
100_D 154_S 1.784 0.99
47_G 57_L 1.782 0.99
100_D 156_T 1.773 0.99
80_K 119_E 1.748 0.99
109_V 167_V 1.724 0.99
207_R 232_N 1.711 0.99
108_V 148_L 1.707 0.99
155_K 159_D 1.705 0.99
155_K 184_L 1.695 0.99
202_S 206_I 1.689 0.99
214_G 233_F 1.67 0.99
203_I 231_A 1.666 0.99
152_V 157_A 1.649 0.99
48_E 121_G 1.622 0.99
83_I 96_I 1.601 0.99
24_L 32_A 1.562 0.98
134_R 248_D 1.561 0.98
204_R 208_A 1.552 0.98
162_D 165_L 1.542 0.98
220_P 253_M 1.542 0.98
100_D 157_A 1.54 0.98
102_A 166_D 1.527 0.98
113_R 143_N 1.523 0.98
33_E 128_R 1.518 0.98
161_L 165_L 1.512 0.98
73_I 91_A 1.508 0.98
155_K 183_S 1.505 0.98
102_A 167_V 1.503 0.98
101_T 104_Q 1.48 0.97
95_L 149_L 1.479 0.97
40_Y 251_L 1.459 0.97
107_Q 111_A 1.454 0.97
36_A 67_Y 1.446 0.97
175_I 180_L 1.422 0.97
96_I 108_V 1.394 0.96
224_Q 228_A 1.384 0.96
72_V 93_T 1.363 0.95
117_Y 143_N 1.361 0.95
35_A 247_L 1.353 0.95
86_V 94_L 1.353 0.95
175_I 202_S 1.35 0.95
78_G 104_Q 1.348 0.95
106_R 167_V 1.324 0.94
99_V 150_V 1.318 0.94
36_A 64_V 1.301 0.93
12_R 19_Q 1.3 0.93
186_Y 189_N 1.299 0.93
186_Y 194_E 1.282 0.93
186_Y 192_H 1.278 0.93
203_I 213_A 1.262 0.92
30_Y 62_Q 1.258 0.92
200_E 204_R 1.251 0.92
71_P 92_Q 1.245 0.91
165_L 205_R 1.244 0.91
76_V 82_L 1.241 0.91
23_W 44_L 1.239 0.91
98_M 123_G 1.227 0.91
106_R 110_S 1.221 0.90
166_D 209_A 1.217 0.90
75_P 83_I 1.215 0.90
110_S 119_E 1.212 0.90
58_Y 62_Q 1.212 0.90
52_N 60_Q 1.21 0.90
79_S 82_L 1.198 0.89
206_I 213_A 1.198 0.89
53_T 56_D 1.193 0.89
159_D 201_T 1.193 0.89
112_T 146_L 1.172 0.88
206_I 209_A 1.164 0.87
217_A 223_A 1.156 0.87
45_I 64_V 1.156 0.87
31_M 243_Y 1.155 0.87
237_G 250_R 1.154 0.87
231_A 234_V 1.148 0.86
105_A 170_I 1.147 0.86
158_L 202_S 1.13 0.85
168_E 211_K 1.13 0.85
23_W 42_W 1.126 0.85
47_G 85_Q 1.112 0.84
59_H 62_Q 1.11 0.84
11_E 15_K 1.107 0.83
83_I 112_T 1.103 0.83
45_I 57_L 1.101 0.83
103_E 107_Q 1.1 0.83
18_V 227_L 1.091 0.82
105_A 164_I 1.087 0.82
115_P 182_A 1.082 0.81
61_L 91_A 1.081 0.81
156_T 159_D 1.079 0.81
154_S 157_A 1.078 0.81
227_L 234_V 1.077 0.81
9_F 147_C 1.074 0.81
249_Q 253_M 1.07 0.80
57_L 73_I 1.068 0.80
138_Y 142_V 1.065 0.80
141_Q 145_S 1.064 0.80
196_Q 225_Q 1.064 0.80
77_E 81_P 1.054 0.79
93_T 147_C 1.041 0.78
75_P 96_I 1.036 0.77
162_D 208_A 1.035 0.77
95_L 172_G 1.03 0.77
171_D 211_K 1.026 0.76
156_T 160_N 1.02 0.76
124_A 130_A 1.019 0.76
238_V 241_M 1.017 0.76
10_K 14_R 1.016 0.75
152_V 173_V 1.012 0.75
163_E 167_V 1.007 0.75
113_R 117_Y 1.004 0.74
24_L 45_I 1 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v5jA20.99631000.292Contact Map0.805
2vwsA311000.303Contact Map0.802
1dxeA20.95511000.308Contact Map0.797
4mf4A60.95511000.335Contact Map0.792
3qz6A10.95511000.336Contact Map0.714
1izcA10.99631000.346Contact Map0.654
1sgjA30.85021000.609Contact Map0.748
2xz9A20.92881000.62Contact Map0.557
3qllA30.88761000.626Contact Map0.718
1u5hA10.81651000.631Contact Map0.566
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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