May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
GARL - 5-keto-4-deoxy-D-glucarate aldolase
UniProt: P23522 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10016
Length: 256 (250)
Sequences: 1029
Seq/Len: 4.12
GARL
Paralog alert: 0.57 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GARL RHMA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_T 160_N 3.331 1.00
149_L 172_G 3.094 1.00
165_A 173_I 2.841 1.00
103_K 107_E 2.75 1.00
162_D 205_R 2.653 1.00
161_V 205_R 2.575 1.00
13_A 18_Q 2.535 1.00
22_G 43_W 2.527 1.00
201_H 205_R 2.404 1.00
76_V 87_L 2.343 1.00
150_V 170_V 2.305 1.00
158_V 198_A 2.225 1.00
79_N 109_A 2.196 1.00
104_E 107_E 2.09 1.00
160_N 163_A 2.034 1.00
200_Q 229_W 2.034 1.00
102_T 156_Q 1.973 1.00
101_E 105_E 1.953 1.00
113_T 148_I 1.892 1.00
162_D 209_H 1.879 1.00
33_T 65_L 1.851 1.00
189_N 192_H 1.85 1.00
71_A 93_Y 1.835 1.00
101_E 156_Q 1.828 1.00
48_G 58_F 1.784 0.99
158_V 161_V 1.769 0.99
101_E 154_S 1.767 0.99
109_A 148_I 1.764 0.99
25_S 33_T 1.758 0.99
81_P 120_I 1.743 0.99
110_V 167_T 1.735 0.99
202_I 206_A 1.721 0.99
155_Q 159_D 1.72 0.99
214_G 233_F 1.714 0.99
155_Q 184_L 1.658 0.99
49_E 122_G 1.651 0.99
207_S 232_T 1.641 0.99
152_I 157_G 1.623 0.99
84_I 97_I 1.619 0.99
204_N 208_A 1.597 0.99
103_K 166_A 1.596 0.99
203_F 231_A 1.591 0.99
161_V 165_A 1.585 0.99
134_T 248_Q 1.581 0.99
34_E 128_R 1.58 0.99
162_D 165_A 1.545 0.98
101_E 157_G 1.537 0.98
155_Q 183_A 1.53 0.98
74_V 92_F 1.519 0.98
114_R 143_N 1.508 0.98
102_T 105_E 1.503 0.98
103_K 167_T 1.464 0.97
220_E 253_T 1.455 0.97
108_L 112_S 1.419 0.96
96_L 149_L 1.416 0.96
37_G 68_S 1.391 0.96
175_V 180_L 1.39 0.96
97_I 109_A 1.389 0.96
41_F 251_A 1.387 0.96
73_V 94_N 1.373 0.96
186_H 189_N 1.366 0.95
224_R 228_E 1.347 0.95
79_N 105_E 1.344 0.95
100_V 150_V 1.344 0.95
118_E 143_N 1.341 0.95
175_V 202_I 1.337 0.95
87_L 95_F 1.328 0.94
13_A 20_Q 1.296 0.93
36_L 247_T 1.292 0.93
24_W 45_V 1.288 0.93
165_A 205_R 1.286 0.93
186_H 192_H 1.274 0.93
203_F 213_S 1.274 0.93
72_P 93_Y 1.27 0.92
37_G 65_L 1.269 0.92
107_E 111_A 1.245 0.91
76_V 84_I 1.244 0.91
31_I 63_M 1.244 0.91
166_A 209_H 1.242 0.91
200_Q 204_N 1.24 0.91
107_E 167_T 1.24 0.91
186_H 194_D 1.234 0.91
111_A 120_I 1.232 0.91
77_P 83_I 1.227 0.91
53_N 61_Q 1.214 0.90
80_E 83_I 1.208 0.90
99_F 124_S 1.204 0.90
206_A 213_S 1.199 0.89
32_S 243_F 1.196 0.89
104_E 108_L 1.188 0.89
59_I 63_M 1.181 0.88
113_T 146_I 1.178 0.88
106_A 170_V 1.171 0.88
54_D 57_T 1.161 0.87
206_A 209_H 1.157 0.87
217_A 223_A 1.153 0.87
237_G 250_L 1.139 0.86
46_L 65_L 1.131 0.85
46_L 58_F 1.127 0.85
12_A 16_A 1.124 0.85
158_V 202_I 1.124 0.85
227_L 234_V 1.121 0.85
116_P 182_A 1.118 0.84
60_P 63_M 1.109 0.84
159_D 201_H 1.103 0.83
231_A 234_V 1.098 0.83
62_L 92_F 1.092 0.82
24_W 43_W 1.079 0.81
141_Q 145_N 1.076 0.81
162_D 208_A 1.074 0.81
156_Q 160_N 1.072 0.81
25_S 65_L 1.069 0.80
11_K 15_A 1.066 0.80
48_G 86_R 1.062 0.80
154_S 157_G 1.062 0.80
84_I 113_T 1.056 0.79
156_Q 159_D 1.056 0.79
94_N 147_T 1.052 0.79
106_A 164_I 1.052 0.79
58_F 74_V 1.05 0.79
96_L 172_G 1.047 0.79
76_V 97_I 1.046 0.78
138_Y 142_S 1.039 0.78
163_A 167_T 1.032 0.77
196_Q 225_R 1.027 0.77
171_D 211_K 1.027 0.77
103_K 163_A 1.024 0.76
10_F 147_T 1.023 0.76
193_P 197_K 1.023 0.76
78_T 82_V 1.022 0.76
220_E 224_R 1.022 0.76
168_E 211_K 1.02 0.76
152_I 173_I 1.016 0.76
85_K 122_G 1.014 0.75
249_K 253_T 1.014 0.75
190_A 195_V 1.011 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v5jA20.99611000.295Contact Map0.799
1dxeA211000.296Contact Map0.793
2vwsA30.99611000.307Contact Map0.796
3qz6A10.98051000.318Contact Map0.717
4mf4A60.99221000.322Contact Map0.794
1izcA111000.333Contact Map0.642
1sgjA30.84381000.596Contact Map0.735
3qllA30.89061000.608Contact Map0.714
2xz9A20.92971000.61Contact Map0.561
1u5hA10.80861000.617Contact Map0.553
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0963 seconds.