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OPENSEQ.org
WZC - Tyrosine-protein kinase wzc
UniProt: P76387 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13568
Length: 720 (704)
Sequences: 1414
Seq/Len: 2.01
WZC
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ETK WZC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
605_D 636_Y 6.431 1.00
559_L 632_A 4.112 1.00
247_N 413_A 3.51 1.00
236_G 242_I 3.474 1.00
585_I 595_A 3.254 1.00
105_D 207_T 3.178 1.00
563_C 641_I 3.166 1.00
595_A 607_I 3.008 1.00
544_C 640_L 2.928 1.00
551_I 638_L 2.707 1.00
472_L 697_S 2.68 1.00
544_C 560_L 2.646 1.00
49_T 427_I 2.602 1.00
392_K 395_E 2.592 1.00
45_A 431_A 2.581 1.00
236_G 241_Q 2.564 1.00
243_R 247_N 2.55 1.00
585_I 607_I 2.539 1.00
286_A 382_G 2.501 1.00
315_N 318_A 2.47 1.00
57_S 420_L 2.43 1.00
528_V 629_V 2.368 1.00
584_E 611_Q 2.36 1.00
530_M 643_T 2.338 1.00
439_S 443_V 2.332 1.00
232_L 246_L 2.282 1.00
667_R 697_S 2.21 1.00
90_E 253_Y 2.206 1.00
581_G 610_G 2.206 1.00
283_L 379_V 2.191 1.00
470_I 543_V 2.187 1.00
307_K 311_D 2.166 1.00
563_C 582_L 2.162 1.00
591_D 594_T 2.157 0.99
19_D 22_R 2.144 0.99
49_T 428_I 2.144 0.99
561_I 639_V 2.12 0.99
629_V 641_I 2.106 0.99
633_S 660_G 2.1 0.99
60_A 250_A 2.088 0.99
531_M 547_L 2.078 0.99
28_I 31_R 2.037 0.99
530_M 659_V 2.028 0.99
327_E 345_L 2.027 0.99
42_A 432_I 2.025 0.99
468_A 513_L 2.024 0.99
528_V 633_S 2.014 0.99
248_S 252_N 1.964 0.99
593_T 635_N 1.935 0.99
101_G 105_D 1.925 0.99
566_R 651_D 1.912 0.98
48_Y 52_A 1.898 0.98
217_S 234_Y 1.894 0.98
326_K 329_E 1.891 0.98
548_A 560_L 1.891 0.98
34_V 38_T 1.887 0.98
596_A 632_A 1.882 0.98
294_R 369_Q 1.868 0.98
565_M 583_S 1.866 0.98
331_S 341_Y 1.862 0.98
243_R 415_T 1.859 0.98
106_D 248_S 1.835 0.98
564_D 645_P 1.833 0.98
234_Y 245_I 1.829 0.98
57_S 235_T 1.819 0.98
613_P 616_P 1.807 0.98
552_S 604_F 1.799 0.98
561_I 641_I 1.798 0.98
320_L 352_E 1.779 0.97
327_E 341_Y 1.761 0.97
527_N 633_S 1.733 0.97
58_A 242_I 1.724 0.97
514_R 618_E 1.696 0.96
158_D 161_N 1.683 0.96
214_L 234_Y 1.651 0.95
664_M 679_S 1.644 0.95
100_L 214_L 1.644 0.95
508_E 651_D 1.634 0.95
91_I 220_V 1.626 0.95
157_L 163_T 1.617 0.95
240_E 244_D 1.612 0.94
255_E 259_E 1.607 0.94
508_E 566_R 1.606 0.94
57_S 233_T 1.606 0.94
598_P 605_D 1.605 0.94
533_G 538_I 1.585 0.94
42_A 428_I 1.584 0.94
561_I 628_L 1.582 0.94
64_I 230_L 1.577 0.94
528_V 659_V 1.576 0.94
565_M 644_P 1.56 0.93
450_N 454_E 1.54 0.93
282_R 382_G 1.53 0.92
559_L 636_Y 1.53 0.92
467_Y 663_L 1.525 0.92
462_H 693_V 1.509 0.91
327_E 331_S 1.507 0.91
157_L 161_N 1.505 0.91
304_L 307_K 1.502 0.91
92_Q 287_E 1.501 0.91
383_Q 387_M 1.495 0.91
292_A 296_D 1.492 0.91
576_T 606_L 1.49 0.91
371_E 374_R 1.482 0.90
532_T 683_F 1.479 0.90
273_A 397_K 1.479 0.90
661_T 691_K 1.472 0.90
38_T 436_L 1.467 0.90
530_M 655_V 1.461 0.90
92_Q 95_R 1.458 0.90
141_F 152_F 1.457 0.89
571_H 578_N 1.451 0.89
423_K 426_L 1.444 0.89
527_N 639_V 1.441 0.89
551_I 640_L 1.44 0.89
631_W 635_N 1.432 0.88
218_L 234_Y 1.424 0.88
275_Q 278_E 1.424 0.88
45_A 427_I 1.423 0.88
557_R 637_D 1.422 0.88
163_T 173_R 1.42 0.88
545_A 574_L 1.419 0.88
470_I 513_L 1.416 0.88
287_E 377_R 1.414 0.88
508_E 511_R 1.414 0.88
336_K 345_L 1.409 0.87
48_Y 427_I 1.397 0.87
331_S 336_K 1.381 0.86
546_N 696_N 1.378 0.86
287_E 383_Q 1.37 0.85
280_R 284_D 1.368 0.85
257_N 406_D 1.367 0.85
104_V 210_M 1.366 0.85
104_V 109_L 1.363 0.85
279_V 389_L 1.362 0.85
64_I 395_E 1.358 0.85
99_V 249_I 1.355 0.84
560_L 640_L 1.354 0.84
568_G 609_R 1.354 0.84
246_L 413_A 1.354 0.84
625_F 655_V 1.353 0.84
290_L 379_V 1.352 0.84
470_I 510_I 1.352 0.84
97_R 411_D 1.349 0.84
460_E 681_S 1.347 0.84
30_A 446_R 1.343 0.84
31_R 35_I 1.342 0.84
665_V 696_N 1.338 0.83
112_A 241_Q 1.337 0.83
618_E 649_V 1.336 0.83
434_L 441_V 1.332 0.83
564_D 567_K 1.328 0.83
344_L 348_R 1.327 0.83
560_L 604_F 1.324 0.82
504_D 507_I 1.323 0.82
380_E 384_Q 1.315 0.82
354_E 357_K 1.315 0.82
552_S 555_N 1.31 0.82
515_T 650_T 1.308 0.81
104_V 214_L 1.307 0.81
235_T 421_K 1.297 0.81
101_G 211_I 1.292 0.80
49_T 52_A 1.291 0.80
623_E 627_E 1.29 0.80
95_R 220_V 1.289 0.80
533_G 540_K 1.288 0.80
534_V 664_M 1.286 0.80
643_T 655_V 1.275 0.79
435_G 439_S 1.274 0.79
508_E 645_P 1.268 0.79
632_A 639_V 1.268 0.79
585_I 628_L 1.266 0.78
61_L 229_V 1.265 0.78
175_Q 178_Q 1.259 0.78
543_V 696_N 1.255 0.78
100_L 245_I 1.254 0.77
53_T 237_E 1.251 0.77
566_R 645_P 1.249 0.77
212_N 216_N 1.244 0.77
540_K 566_R 1.242 0.77
559_L 639_V 1.241 0.76
644_P 652_A 1.237 0.76
283_L 287_E 1.231 0.76
376_T 380_E 1.223 0.75
566_R 649_V 1.222 0.75
233_T 436_L 1.218 0.75
382_G 385_V 1.216 0.74
421_K 426_L 1.214 0.74
104_V 211_I 1.212 0.74
246_L 250_A 1.207 0.74
313_M 362_V 1.205 0.73
334_Y 338_H 1.204 0.73
155_N 163_T 1.204 0.73
345_L 348_R 1.2 0.73
317_D 355_K 1.199 0.73
513_L 694_I 1.195 0.73
590_G 595_A 1.194 0.72
273_A 393_E 1.194 0.72
510_I 543_V 1.192 0.72
534_V 679_S 1.189 0.72
162_Y 176_A 1.188 0.72
272_L 366_P 1.188 0.72
540_K 642_D 1.188 0.72
27_V 34_V 1.186 0.72
558_V 639_V 1.185 0.72
382_G 394_Q 1.184 0.72
155_N 165_S 1.18 0.71
97_R 211_I 1.178 0.71
91_I 230_L 1.175 0.71
540_K 564_D 1.175 0.71
289_K 378_D 1.174 0.71
269_L 396_L 1.172 0.70
285_V 289_K 1.17 0.70
279_V 385_V 1.165 0.70
511_R 542_F 1.163 0.70
288_N 292_A 1.156 0.69
162_Y 180_L 1.155 0.69
248_S 251_R 1.153 0.69
161_N 175_Q 1.153 0.69
287_E 374_R 1.152 0.69
583_S 610_G 1.149 0.68
539_G 696_N 1.149 0.68
60_A 232_L 1.148 0.68
587_I 614_P 1.145 0.68
646_I 653_A 1.145 0.68
596_A 636_Y 1.143 0.68
327_E 348_R 1.141 0.67
47_V 51_F 1.141 0.67
583_S 619_L 1.139 0.67
556_K 638_L 1.138 0.67
41_F 435_G 1.137 0.67
436_L 439_S 1.136 0.67
100_L 215_Q 1.134 0.67
103_T 347_K 1.132 0.67
532_T 662_T 1.129 0.66
271_F 377_R 1.126 0.66
267_K 270_A 1.125 0.66
229_V 410_V 1.118 0.65
31_R 534_V 1.114 0.65
88_D 227_A 1.113 0.65
546_N 618_E 1.112 0.65
330_I 341_Y 1.111 0.64
293_F 371_E 1.11 0.64
585_I 592_I 1.11 0.64
541_T 642_D 1.109 0.64
607_I 628_L 1.109 0.64
547_L 663_L 1.108 0.64
519_F 614_P 1.107 0.64
370_Q 374_R 1.103 0.64
531_M 663_L 1.102 0.64
471_P 509_A 1.1 0.63
310_L 517_L 1.1 0.63
157_L 160_K 1.098 0.63
538_I 568_G 1.093 0.63
323_L 606_L 1.092 0.62
42_A 436_L 1.09 0.62
628_L 632_A 1.09 0.62
636_Y 639_V 1.088 0.62
319_Q 322_E 1.083 0.62
102_K 106_D 1.083 0.62
33_W 37_I 1.079 0.61
100_L 227_A 1.079 0.61
508_E 540_K 1.078 0.61
320_L 348_R 1.07 0.60
100_L 249_I 1.069 0.60
316_I 355_K 1.068 0.60
46_V 428_I 1.067 0.60
345_L 349_Q 1.067 0.60
156_V 192_I 1.066 0.60
530_M 541_T 1.065 0.60
559_L 596_A 1.064 0.59
272_L 392_K 1.063 0.59
453_I 676_V 1.061 0.59
597_K 608_P 1.061 0.59
214_L 218_L 1.061 0.59
271_F 401_A 1.061 0.59
584_E 614_P 1.06 0.59
116_N 199_E 1.059 0.59
214_L 245_I 1.058 0.59
320_L 351_L 1.057 0.59
49_T 431_A 1.055 0.59
161_N 173_R 1.054 0.58
30_A 443_V 1.053 0.58
59_D 231_S 1.051 0.58
75_D 78_S 1.051 0.58
390_L 393_E 1.048 0.58
26_T 444_L 1.047 0.58
656_G 688_I 1.045 0.57
210_M 529_L 1.044 0.57
101_G 207_T 1.043 0.57
58_A 415_T 1.042 0.57
570_T 606_L 1.04 0.57
596_A 605_D 1.04 0.57
419_V 422_P 1.039 0.57
583_S 613_P 1.038 0.57
563_C 625_F 1.037 0.57
46_V 50_F 1.036 0.56
583_S 614_P 1.036 0.56
508_E 649_V 1.035 0.56
92_Q 223_N 1.035 0.56
93_L 253_Y 1.031 0.56
438_L 441_V 1.031 0.56
631_W 634_K 1.03 0.56
545_A 570_T 1.03 0.56
108_D 354_E 1.028 0.56
323_L 348_R 1.023 0.55
62_V 639_V 1.023 0.55
571_H 608_P 1.022 0.55
539_G 564_D 1.02 0.55
392_K 399_T 1.019 0.55
504_D 538_I 1.018 0.54
93_L 309_V 1.018 0.54
666_A 676_V 1.017 0.54
94_I 232_L 1.016 0.54
98_L 411_D 1.016 0.54
597_K 607_I 1.015 0.54
529_L 638_L 1.014 0.54
286_A 379_V 1.014 0.54
155_N 199_E 1.013 0.54
330_I 344_L 1.013 0.54
626_A 630_N 1.01 0.54
373_V 376_T 1.009 0.53
506_A 542_F 1.006 0.53
508_E 564_D 1.004 0.53
626_A 658_H 1 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3la6A160.39441000.647Contact Map0.798
3cioA20.39721000.647Contact Map0.735
3bfvA20.37221000.671Contact Map0.759
3ug7A40.31000.819Contact Map0.366
1g3qA10.26941000.822Contact Map0.729
3fkqA10.44861000.826Contact Map0.585
1hyqA10.26811000.827Contact Map0.641
3ea0A20.27221000.83Contact Map0.645
3endA20.31941000.831Contact Map0.543
3q9lA20.26811000.833Contact Map0.701
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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