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OPENSEQ.org
ETK - Tyrosine-protein kinase etk
UniProt: P38134 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11826
Length: 726 (702)
Sequences: 1412
Seq/Len: 2.01
ETK
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ETK WZC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
610_D 641_Y 6.464 1.00
564_L 637_A 4.24 1.00
247_N 413_A 3.454 1.00
236_G 242_I 3.351 1.00
590_Y 600_V 3.323 1.00
568_A 646_V 3.17 1.00
105_A 207_E 3.166 1.00
549_S 645_I 3.023 1.00
600_V 612_I 2.909 1.00
472_M 702_G 2.894 1.00
556_I 643_L 2.846 1.00
49_S 427_N 2.696 1.00
549_S 565_F 2.694 1.00
286_A 382_G 2.634 1.00
45_A 431_G 2.585 1.00
392_R 395_E 2.57 1.00
243_T 247_N 2.563 1.00
236_G 241_L 2.547 1.00
590_Y 612_I 2.509 1.00
535_M 648_T 2.455 1.00
57_Q 420_V 2.435 1.00
589_E 616_Q 2.425 1.00
315_N 318_N 2.404 1.00
439_S 443_V 2.351 1.00
232_L 246_L 2.348 1.00
533_I 634_L 2.299 1.00
566_I 644_V 2.291 1.00
568_A 587_L 2.273 1.00
672_R 702_G 2.263 1.00
283_L 379_V 2.222 1.00
586_G 615_G 2.215 1.00
90_E 253_Y 2.2 1.00
19_D 22_R 2.135 0.99
596_E 599_K 2.121 0.99
60_T 250_A 2.099 0.99
536_I 552_L 2.064 0.99
49_S 428_V 2.058 0.99
468_A 518_L 2.047 0.99
634_L 646_V 2.04 0.99
42_T 432_F 2.036 0.99
307_K 311_E 2.031 0.99
535_M 664_V 2.027 0.99
638_N 665_G 2.012 0.99
533_I 638_N 1.974 0.99
569_D 650_P 1.97 0.99
327_E 345_L 1.969 0.99
28_W 31_R 1.968 0.99
331_S 341_Y 1.955 0.99
217_T 234_M 1.955 0.99
470_I 548_V 1.93 0.99
248_S 252_N 1.928 0.99
243_T 415_T 1.928 0.99
570_L 588_S 1.914 0.99
294_R 369_Q 1.908 0.98
101_G 105_A 1.901 0.98
467_Y 668_L 1.855 0.98
598_N 640_H 1.855 0.98
571_R 656_D 1.852 0.98
57_Q 235_T 1.842 0.98
48_Y 52_S 1.835 0.98
553_A 565_F 1.819 0.98
618_P 621_P 1.809 0.98
601_I 637_A 1.806 0.98
557_A 609_F 1.795 0.97
327_E 341_Y 1.781 0.97
100_L 214_L 1.777 0.97
234_M 245_I 1.757 0.97
326_R 329_E 1.752 0.97
106_E 248_S 1.738 0.97
320_L 352_E 1.734 0.97
91_I 220_V 1.724 0.97
34_I 38_T 1.71 0.96
513_E 571_R 1.7 0.96
532_N 638_N 1.697 0.96
513_E 656_D 1.697 0.96
566_I 646_V 1.691 0.96
669_L 684_S 1.684 0.96
450_R 454_E 1.684 0.96
519_R 623_E 1.658 0.95
535_M 660_V 1.65 0.95
57_Q 233_T 1.63 0.95
273_Q 397_S 1.628 0.95
630_M 660_V 1.622 0.95
537_T 688_L 1.617 0.95
538_G 543_S 1.612 0.94
42_T 428_V 1.606 0.94
564_L 641_Y 1.599 0.94
58_A 242_I 1.595 0.94
214_L 234_M 1.592 0.94
581_V 611_V 1.588 0.94
566_I 633_L 1.576 0.94
240_Q 244_R 1.571 0.93
470_I 518_L 1.56 0.93
282_E 382_G 1.555 0.93
513_E 516_R 1.55 0.93
255_Q 259_A 1.54 0.93
64_V 230_L 1.52 0.92
556_I 645_I 1.519 0.92
92_Q 287_E 1.517 0.92
304_L 307_K 1.515 0.92
336_K 345_L 1.51 0.92
462_H 698_A 1.502 0.91
576_H 583_N 1.495 0.91
141_M 153_L 1.49 0.91
159_E 162_H 1.487 0.91
257_N 406_N 1.479 0.90
371_E 374_R 1.47 0.90
513_E 650_P 1.469 0.90
509_D 512_V 1.463 0.90
533_I 664_V 1.456 0.89
331_S 336_K 1.448 0.89
551_T 701_N 1.447 0.89
603_H 610_D 1.446 0.89
383_R 387_L 1.436 0.89
570_L 649_P 1.435 0.89
292_V 296_Q 1.432 0.88
565_F 645_I 1.432 0.88
423_K 426_L 1.423 0.88
666_T 696_K 1.421 0.88
48_Y 427_N 1.419 0.88
38_T 436_L 1.418 0.88
164_T 173_N 1.417 0.88
569_D 572_R 1.414 0.88
30_H 446_R 1.409 0.87
518_L 699_I 1.402 0.87
565_F 609_F 1.397 0.87
670_V 701_N 1.397 0.87
218_F 234_M 1.387 0.86
246_L 413_A 1.387 0.86
158_G 164_T 1.384 0.86
550_S 579_F 1.384 0.86
327_E 331_S 1.382 0.86
45_A 427_N 1.382 0.86
623_E 654_V 1.379 0.86
532_N 644_V 1.375 0.86
636_W 640_H 1.368 0.85
562_K 642_D 1.364 0.85
212_N 216_E 1.357 0.84
112_I 241_L 1.354 0.84
470_I 515_V 1.354 0.84
515_V 548_V 1.353 0.84
571_R 650_P 1.347 0.84
539_A 669_L 1.341 0.84
158_G 162_H 1.339 0.83
104_I 210_A 1.337 0.83
49_S 52_S 1.336 0.83
64_V 395_E 1.335 0.83
290_L 379_V 1.331 0.83
648_T 660_V 1.328 0.83
104_I 109_L 1.327 0.83
280_R 284_D 1.325 0.83
287_E 383_R 1.323 0.82
287_E 377_R 1.321 0.82
376_S 380_E 1.319 0.82
590_Y 633_L 1.318 0.82
272_L 366_P 1.311 0.82
545_K 571_R 1.308 0.81
99_I 249_I 1.305 0.81
92_Q 95_Q 1.303 0.81
275_Q 278_E 1.301 0.81
279_V 385_V 1.301 0.81
571_R 654_V 1.3 0.81
557_A 560_D 1.299 0.81
97_R 411_D 1.299 0.81
354_E 357_R 1.298 0.81
564_L 644_V 1.298 0.81
460_E 686_Q 1.297 0.81
313_I 362_V 1.296 0.81
573_G 614_R 1.294 0.80
31_R 35_I 1.292 0.80
536_I 668_L 1.288 0.80
548_V 701_N 1.287 0.80
538_G 545_K 1.283 0.80
520_T 655_S 1.281 0.79
434_L 441_G 1.272 0.79
561_Q 643_L 1.27 0.79
100_L 245_I 1.27 0.79
382_G 385_V 1.267 0.78
246_L 250_A 1.265 0.78
279_V 389_L 1.264 0.78
61_L 229_M 1.264 0.78
95_Q 220_V 1.242 0.77
592_A 619_P 1.241 0.76
545_K 569_D 1.239 0.76
421_K 426_L 1.238 0.76
229_M 410_I 1.232 0.76
537_T 667_S 1.232 0.76
248_S 251_N 1.23 0.76
471_P 514_A 1.226 0.75
60_T 232_L 1.226 0.75
380_E 384_A 1.222 0.75
104_I 214_L 1.215 0.74
269_L 396_L 1.214 0.74
575_S 611_V 1.212 0.74
334_Y 338_H 1.209 0.74
283_L 287_E 1.201 0.73
53_T 237_D 1.201 0.73
563_V 644_V 1.2 0.73
289_K 378_D 1.199 0.73
317_D 355_R 1.195 0.73
602_Q 613_T 1.189 0.72
628_D 632_Q 1.181 0.71
382_G 394_Q 1.18 0.71
516_R 547_F 1.178 0.71
327_E 348_R 1.177 0.71
267_Q 270_E 1.171 0.70
612_I 633_L 1.171 0.70
513_E 569_D 1.166 0.70
91_I 230_L 1.165 0.70
101_G 211_I 1.163 0.70
544_G 701_N 1.161 0.69
509_D 543_S 1.16 0.69
49_S 431_G 1.158 0.69
649_P 657_A 1.157 0.69
344_L 348_R 1.156 0.69
637_A 644_V 1.15 0.68
273_Q 393_Q 1.15 0.68
310_L 522_L 1.147 0.68
601_I 641_Y 1.146 0.68
435_G 439_S 1.145 0.68
59_D 231_E 1.145 0.68
33_F 37_V 1.139 0.67
235_T 421_K 1.137 0.67
545_K 647_D 1.135 0.67
100_L 249_I 1.128 0.66
271_F 366_P 1.125 0.66
62_V 644_V 1.124 0.66
588_S 624_L 1.123 0.66
98_M 411_D 1.121 0.65
108_N 301_D 1.12 0.65
41_F 435_G 1.119 0.65
513_E 545_K 1.117 0.65
601_I 610_D 1.117 0.65
310_L 389_L 1.115 0.65
641_Y 644_V 1.113 0.65
671_A 681_V 1.111 0.64
233_T 436_L 1.108 0.64
436_L 439_S 1.106 0.64
97_R 211_I 1.106 0.64
543_S 573_G 1.097 0.63
438_I 441_G 1.096 0.63
511_A 547_F 1.095 0.63
320_L 351_L 1.094 0.63
564_L 601_I 1.091 0.62
539_A 684_S 1.09 0.62
37_V 439_S 1.087 0.62
636_W 639_D 1.086 0.62
588_S 615_G 1.086 0.62
31_R 539_A 1.084 0.62
595_D 600_V 1.084 0.62
100_L 215_Q 1.082 0.61
287_E 374_R 1.08 0.61
323_L 611_V 1.08 0.61
524_F 619_P 1.08 0.61
588_S 618_P 1.08 0.61
58_A 415_T 1.078 0.61
88_A 227_S 1.078 0.61
271_F 401_S 1.076 0.61
214_L 218_F 1.072 0.60
370_Q 374_R 1.07 0.60
345_L 348_R 1.069 0.60
563_V 566_I 1.069 0.60
571_R 647_D 1.067 0.60
101_G 207_E 1.066 0.60
293_Y 371_E 1.065 0.60
633_L 637_A 1.062 0.59
271_F 377_R 1.061 0.59
93_L 253_Y 1.058 0.59
103_T 347_K 1.057 0.59
390_L 393_Q 1.052 0.58
285_Q 289_K 1.052 0.58
46_V 50_L 1.05 0.58
453_V 681_V 1.047 0.58
587_L 633_L 1.047 0.58
513_E 654_V 1.045 0.57
92_Q 229_M 1.044 0.57
516_R 569_D 1.044 0.57
551_T 623_E 1.032 0.56
590_Y 597_L 1.026 0.55
587_L 624_L 1.026 0.55
316_V 355_R 1.025 0.55
286_A 379_V 1.024 0.55
104_I 211_I 1.024 0.55
175_M 178_Q 1.023 0.55
97_R 101_G 1.023 0.55
520_T 659_V 1.022 0.55
320_L 348_R 1.02 0.55
597_L 612_I 1.02 0.55
563_V 642_D 1.018 0.54
517_A 579_F 1.018 0.54
635_E 638_N 1.015 0.54
242_I 246_L 1.015 0.54
392_R 399_S 1.014 0.54
257_N 405_G 1.014 0.54
588_S 619_P 1.012 0.54
516_R 545_K 1.011 0.54
545_K 654_V 1.011 0.54
244_R 248_S 1.008 0.53
650_P 654_V 1.007 0.53
46_V 428_V 1.007 0.53
210_A 534_L 1.007 0.53
94_L 99_I 1.006 0.53
100_L 227_S 1.005 0.53
345_L 349_Q 1.004 0.53
518_L 566_I 1.003 0.53
293_Y 368_T 1.002 0.53
568_A 630_M 1.001 0.53
94_L 232_L 1.001 0.53
27_L 34_I 1 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cioA20.40361000.639Contact Map0.713
3la6A160.39121000.655Contact Map0.781
3bfvA20.36911000.675Contact Map0.733
3ug7A40.29891000.817Contact Map0.342
1g3qA10.26861000.821Contact Map0.729
3fkqA10.44631000.824Contact Map0.578
1hyqA10.26721000.825Contact Map0.636
3ea0A20.27131000.826Contact Map0.652
3endA20.32091000.83Contact Map0.535
1wcv110.26721000.831Contact Map0.682
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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