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OPENSEQ.org
UDG - UDP-glucose 6-dehydrogenase
UniProt: P76373 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13407
Length: 388 (375)
Sequences: 3542
Seq/Len: 9.45
UDG
Paralog alert: 0.62 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: UDG WECC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_P 36_A 5.848 1.00
125_A 191_T 4.346 1.00
2_K 24_E 3.318 1.00
298_V 331_E 3.246 1.00
37_M 42_I 3.133 1.00
291_I 364_I 2.857 1.00
188_T 227_Q 2.745 1.00
66_D 69_E 2.731 1.00
298_V 333_I 2.677 1.00
36_A 40_D 2.65 1.00
301_I 322_M 2.596 1.00
4_T 74_A 2.571 1.00
188_T 196_I 2.491 1.00
300_G 360_A 2.484 1.00
219_E 290_A 2.477 1.00
271_N 278_D 2.312 1.00
309_G 370_E 2.298 1.00
224_N 227_Q 2.298 1.00
189_D 192_E 2.289 1.00
39_N 63_A 2.285 1.00
305_I 339_M 2.224 1.00
137_I 171_A 2.184 1.00
33_S 36_A 2.177 1.00
24_E 62_N 2.166 1.00
150_Y 154_H 2.15 1.00
291_I 362_V 2.136 1.00
285_D 324_R 2.112 1.00
21_Q 56_S 2.107 1.00
43_S 54_L 2.101 1.00
108_N 111_A 2.062 1.00
200_A 232_V 2.003 1.00
164_S 167_A 1.993 1.00
29_D 35_V 1.964 1.00
38_L 61_F 1.946 1.00
77_V 111_A 1.939 1.00
8_T 27_A 1.93 1.00
202_T 210_Y 1.919 1.00
352_D 355_T 1.909 1.00
98_E 102_K 1.907 1.00
292_L 328_K 1.9 1.00
81_T 84_D 1.899 1.00
168_E 187_F 1.872 1.00
168_E 172_A 1.87 1.00
32_P 65_L 1.867 1.00
299_V 330_V 1.859 1.00
24_E 60_H 1.839 1.00
52_Q 56_S 1.837 1.00
135_N 164_S 1.829 1.00
333_I 360_A 1.828 1.00
206_M 276_I 1.802 1.00
99_S 102_K 1.801 1.00
300_G 356_F 1.769 1.00
195_A 218_A 1.754 1.00
68_N 72_R 1.712 1.00
102_K 130_K 1.695 1.00
17_L 54_L 1.685 1.00
324_R 327_A 1.68 1.00
67_K 103_D 1.666 1.00
269_P 274_S 1.653 1.00
17_L 53_F 1.637 1.00
36_A 39_N 1.625 1.00
129_K 136_I 1.614 1.00
163_R 166_R 1.608 1.00
113_M 131_Y 1.586 1.00
62_N 69_E 1.586 1.00
203_Y 207_R 1.566 1.00
35_V 63_A 1.564 1.00
31_L 34_R 1.553 1.00
17_L 61_F 1.527 1.00
262_L 274_S 1.525 1.00
286_F 290_A 1.515 1.00
165_E 168_E 1.507 1.00
18_L 21_Q 1.467 1.00
272_L 279_A 1.457 1.00
218_A 225_S 1.455 1.00
28_L 64_T 1.45 1.00
333_I 350_E 1.443 1.00
6_S 100_V 1.442 1.00
335_Y 372_L 1.429 0.99
112_V 137_I 1.422 0.99
69_E 73_D 1.418 0.99
28_L 67_K 1.413 0.99
39_N 62_N 1.388 0.99
26_V 62_N 1.387 0.99
102_K 106_E 1.374 0.99
203_Y 239_G 1.369 0.99
274_S 278_D 1.365 0.99
2_K 73_D 1.362 0.99
288_A 321_I 1.355 0.99
104_V 113_M 1.353 0.99
230_E 240_N 1.353 0.99
320_G 323_K 1.341 0.99
34_R 44_P 1.34 0.99
86_D 91_Y 1.34 0.99
35_V 65_L 1.338 0.99
221_L 266_Q 1.335 0.99
217_Y 270_N 1.319 0.99
135_N 166_R 1.318 0.99
165_E 169_R 1.317 0.99
249_Y 277_V 1.312 0.99
76_Y 174_L 1.305 0.99
206_M 272_L 1.304 0.99
220_S 268_V 1.302 0.99
23_H 176_E 1.301 0.99
37_M 44_P 1.296 0.99
216_S 283_R 1.291 0.99
126_A 130_K 1.291 0.99
107_I 111_A 1.289 0.99
227_Q 230_E 1.284 0.99
216_S 286_F 1.283 0.99
172_A 187_F 1.281 0.99
192_E 223_L 1.278 0.99
219_E 286_F 1.277 0.99
4_T 77_V 1.271 0.99
174_L 177_G 1.267 0.99
226_R 230_E 1.26 0.98
319_Q 323_K 1.26 0.98
49_E 52_Q 1.257 0.98
270_N 273_I 1.256 0.98
76_Y 112_V 1.251 0.98
299_V 362_V 1.243 0.98
355_T 358_Q 1.241 0.98
53_F 149_L 1.233 0.98
68_N 106_E 1.233 0.98
325_I 330_V 1.216 0.98
72_R 108_N 1.21 0.98
318_I 366_N 1.209 0.98
3_I 174_L 1.208 0.98
38_L 63_A 1.203 0.98
308_S 368_M 1.202 0.98
169_R 172_A 1.196 0.98
169_R 173_L 1.193 0.98
322_M 326_K 1.187 0.97
8_T 16_G 1.186 0.97
192_E 228_I 1.177 0.97
285_D 289_D 1.17 0.97
2_K 26_V 1.167 0.97
272_L 275_A 1.161 0.97
350_E 355_T 1.159 0.97
95_S 99_S 1.15 0.97
99_S 103_D 1.145 0.97
199_F 214_L 1.142 0.97
331_E 348_R 1.141 0.97
4_T 28_L 1.139 0.97
353_L 357_K 1.138 0.97
110_Y 135_N 1.137 0.96
112_V 170_F 1.136 0.96
214_L 225_S 1.136 0.96
211_F 229_I 1.135 0.96
323_K 326_K 1.134 0.96
128_H 163_R 1.131 0.96
147_K 150_Y 1.129 0.96
216_S 220_S 1.121 0.96
105_V 131_Y 1.12 0.96
291_I 299_V 1.117 0.96
75_D 111_A 1.115 0.96
206_M 210_Y 1.113 0.96
333_I 359_Q 1.112 0.96
324_R 328_K 1.097 0.95
98_E 127_M 1.087 0.95
162_E 168_E 1.085 0.95
21_Q 153_L 1.084 0.95
125_A 129_K 1.083 0.95
110_Y 166_R 1.082 0.95
236_P 241_H 1.082 0.95
51_Q 55_Q 1.078 0.95
76_Y 170_F 1.075 0.95
18_L 153_L 1.074 0.95
304_L 313_F 1.073 0.95
300_G 333_I 1.071 0.95
33_S 37_M 1.07 0.95
26_V 64_T 1.067 0.94
54_L 61_F 1.067 0.94
162_E 166_R 1.066 0.94
205_A 277_V 1.066 0.94
37_M 40_D 1.065 0.94
271_N 282_T 1.058 0.94
304_L 334_I 1.053 0.94
42_I 55_Q 1.051 0.94
23_H 177_G 1.05 0.94
304_L 316_S 1.05 0.94
18_L 152_N 1.046 0.94
370_E 373_K 1.042 0.94
98_E 126_A 1.04 0.93
26_V 73_D 1.037 0.93
282_T 289_D 1.032 0.93
296_P 331_E 1.029 0.93
77_V 104_V 1.019 0.93
64_T 70_A 1.018 0.92
30_I 96_S 1.015 0.92
339_M 349_L 1.014 0.92
288_A 324_R 1.002 0.92
300_G 363_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pidA111000.253Contact Map0.702
1dljA111000.259Contact Map0.674
2y0cA40.99741000.275Contact Map0.774
4a7pA211000.288Contact Map0.621
2o3jA30.99741000.295Contact Map0.709
2q3eA120.99741000.303Contact Map0.74
3ojoA20.96131000.312Contact Map0.783
3gg2A40.99741000.312Contact Map0.772
3vtfA10.98971000.321Contact Map0.705
3g79A20.9821000.321Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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