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WECC - UDP-N-acetyl-D-mannosamine dehydrogenase
UniProt: P27829 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11452
Length: 420 (409)
Sequences: 3560
Seq/Len: 8.70
WECC
Paralog alert: 0.62 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: UDG WECC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_Q 40_D 6.005 1.00
127_E 206_R 4.35 1.00
360_V 399_F 4.199 1.00
333_N 397_S 3.541 1.00
303_V 391_V 3.435 1.00
322_K 356_E 3.33 1.00
5_T 28_Q 3.305 1.00
181_T 184_C 3.272 1.00
41_T 46_E 3.068 1.00
155_A 188_A 2.83 1.00
203_T 242_E 2.754 1.00
322_K 358_L 2.65 1.00
7_S 76_A 2.598 1.00
40_D 44_R 2.562 1.00
324_A 387_A 2.545 1.00
24_S 60_T 2.482 1.00
325_C 346_A 2.461 1.00
203_T 211_C 2.444 1.00
234_A 302_Q 2.417 1.00
153_N 181_T 2.368 1.00
239_N 242_E 2.336 1.00
204_N 207_T 2.284 1.00
28_Q 68_R 2.233 1.00
283_R 290_E 2.21 1.00
329_A 364_I 2.194 1.00
43_N 69_A 2.149 1.00
103_R 136_M 2.105 1.00
168_V 172_K 2.103 1.00
345_I 393_L 2.102 1.00
37_H 40_D 2.092 1.00
324_A 383_A 2.073 1.00
303_V 389_V 2.061 1.00
110_K 113_A 2.031 1.00
185_S 202_V 2.02 1.00
297_F 348_L 2.016 1.00
20_A 58_V 2.011 1.00
215_E 247_A 2.009 1.00
47_I 58_V 2.004 1.00
42_I 67_L 1.962 1.00
78_A 191_L 1.959 1.00
27_K 194_I 1.955 1.00
103_R 132_W 1.952 1.00
28_Q 66_F 1.918 1.00
186_A 190_E 1.917 1.00
79_W 113_A 1.903 1.00
379_Q 382_E 1.884 1.00
11_L 31_G 1.884 1.00
33_D 39_V 1.866 1.00
358_L 387_A 1.855 1.00
217_S 225_F 1.84 1.00
99_E 103_R 1.819 1.00
221_V 288_A 1.808 1.00
36_Q 71_T 1.803 1.00
100_S 103_R 1.79 1.00
210_M 233_C 1.769 1.00
56_S 60_T 1.768 1.00
115_V 133_L 1.759 1.00
20_A 57_V 1.746 1.00
281_Q 286_R 1.703 1.00
131_E 154_I 1.668 1.00
260_P 415_A 1.668 1.00
185_S 189_S 1.668 1.00
323_I 355_G 1.668 1.00
304_K 353_H 1.667 1.00
40_D 43_N 1.609 1.00
20_A 67_L 1.602 1.00
24_S 61_A 1.596 1.00
279_P 286_R 1.584 1.00
179_G 185_S 1.576 1.00
141_T 150_A 1.561 1.00
392_M 418_V 1.56 1.00
332_P 395_D 1.543 1.00
358_L 377_L 1.534 1.00
59_K 63_E 1.512 1.00
32_V 70_S 1.51 1.00
233_C 240_V 1.504 1.00
218_F 222_N 1.499 1.00
348_L 352_W 1.493 1.00
298_W 302_Q 1.493 1.00
39_V 69_A 1.49 1.00
284_L 291_V 1.484 1.00
275_V 286_R 1.48 1.00
22_F 191_L 1.469 1.00
35_N 38_A 1.458 0.99
9_I 101_A 1.445 0.99
21_A 24_S 1.422 0.99
186_A 201_V 1.419 0.99
114_L 155_A 1.419 0.99
6_I 191_L 1.416 0.99
128_K 132_W 1.407 0.99
103_R 107_P 1.404 0.99
232_I 282_A 1.382 0.99
73_P 104_S 1.375 0.99
30_I 68_R 1.37 0.99
182_P 186_A 1.367 0.99
105_I 115_V 1.365 0.99
282_A 285_I 1.359 0.99
300_I 345_I 1.354 0.99
38_A 48_H 1.349 0.99
242_E 245_R 1.343 0.99
382_E 385_A 1.338 0.99
39_V 71_T 1.334 0.99
306_A 413_V 1.329 0.99
344_E 347_E 1.323 0.99
88_K 92_E 1.317 0.99
43_N 68_R 1.315 0.99
131_E 135_E 1.311 0.99
323_I 389_V 1.304 0.99
349_I 355_G 1.288 0.98
41_T 48_H 1.287 0.98
53_D 56_S 1.285 0.98
114_L 187_R 1.284 0.98
262_V 289_R 1.276 0.98
231_L 295_K 1.275 0.98
5_T 30_I 1.272 0.98
218_F 254_N 1.271 0.98
221_V 284_L 1.268 0.98
189_S 202_V 1.265 0.98
388_D 408_H 1.264 0.98
78_A 114_L 1.261 0.98
234_A 298_W 1.259 0.98
42_I 69_A 1.255 0.98
286_R 290_E 1.242 0.98
343_M 347_E 1.242 0.98
109_L 113_A 1.237 0.98
231_L 298_W 1.236 0.98
43_N 62_V 1.223 0.98
7_S 79_W 1.221 0.98
11_L 19_A 1.218 0.98
207_T 238_I 1.205 0.97
303_V 413_V 1.196 0.97
151_D 183_V 1.195 0.97
19_A 67_L 1.193 0.97
326_F 402_I 1.187 0.97
241_W 245_R 1.184 0.97
358_L 386_T 1.183 0.97
324_A 390_L 1.183 0.97
186_A 189_S 1.182 0.97
229_L 240_V 1.176 0.97
24_S 171_I 1.175 0.97
78_A 187_R 1.17 0.97
207_T 243_L 1.163 0.97
284_L 287_T 1.161 0.96
182_P 185_S 1.161 0.96
106_A 133_L 1.161 0.96
32_V 73_P 1.16 0.96
221_V 225_F 1.143 0.96
356_E 375_C 1.141 0.96
231_L 235_D 1.14 0.96
86_P 94_D 1.13 0.96
112_G 153_N 1.13 0.96
157_C 192_Y 1.129 0.96
58_V 62_V 1.129 0.96
214_T 229_L 1.125 0.96
74_V 108_V 1.125 0.96
403_N 406_N 1.123 0.96
77_D 113_A 1.121 0.95
395_D 416_K 1.118 0.95
96_T 100_S 1.114 0.95
116_I 191_L 1.112 0.95
297_F 301_D 1.107 0.95
30_I 75_E 1.106 0.95
103_R 133_L 1.103 0.95
389_V 413_V 1.102 0.95
165_Q 168_V 1.098 0.95
100_S 104_S 1.096 0.95
57_V 167_M 1.095 0.95
283_R 294_H 1.092 0.95
74_V 107_P 1.086 0.94
21_A 171_I 1.077 0.94
125_S 129_M 1.061 0.93
226_A 244_I 1.059 0.93
21_A 170_L 1.059 0.93
58_V 67_L 1.054 0.93
99_E 129_M 1.052 0.93
30_I 70_S 1.05 0.93
377_L 382_E 1.05 0.93
392_M 419_W 1.05 0.93
378_A 382_E 1.047 0.93
153_N 184_C 1.037 0.92
220_D 289_R 1.035 0.92
81_I 98_V 1.034 0.92
328_L 337_L 1.032 0.92
41_T 44_R 1.032 0.92
34_I 97_Y 1.028 0.92
55_A 59_K 1.026 0.92
7_S 32_V 1.026 0.92
37_H 41_T 1.021 0.92
81_I 115_V 1.021 0.92
241_W 257_Q 1.017 0.91
324_A 358_L 1.017 0.91
30_I 76_A 1.016 0.91
363_N 398_Q 1.01 0.91
103_R 135_E 1.008 0.91
342_A 393_L 1.005 0.91
130_A 180_M 1.001 0.90
127_E 131_E 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2y0cA40.96671000.256Contact Map0.803
3ojoA20.94521000.262Contact Map0.803
4a7pA20.95711000.273Contact Map0.669
3g79A20.96431000.279Contact Map0.793
2o3jA30.96191000.282Contact Map0.738
2q3eA120.95711000.284Contact Map0.765
3gg2A40.96431000.286Contact Map0.799
3vtfA10.94521000.301Contact Map0.733
1mv8A40.94521000.317Contact Map0.787
3pidA10.91191000.335Contact Map0.688
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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