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OPENSEQ.org
WZZB - Chain length determinant protein
UniProt: P76372 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13406
Length: 326 (306)
Sequences: 1729
Seq/Len: 5.65
WZZB
Paralog alert: 0.67 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: FEPE WZZB WZZE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
149_A 284_P 3.951 1.00
138_G 144_A 3.52 1.00
48_Y 52_A 3.48 1.00
45_A 302_A 3.344 1.00
57_T 291_D 3.337 1.00
310_G 314_V 3.111 1.00
49_L 298_T 2.878 1.00
57_T 137_V 2.826 1.00
28_W 31_K 2.782 1.00
138_G 143_G 2.676 1.00
42_I 303_V 2.544 1.00
60_A 152_I 2.472 1.00
294_K 297_I 2.464 1.00
197_I 259_R 2.42 1.00
137_V 292_S 2.379 1.00
19_D 22_D 2.378 1.00
145_Q 286_L 2.363 1.00
58_S 144_A 2.334 1.00
150_Q 161_Q 2.244 1.00
145_Q 149_A 2.215 1.00
49_L 299_L 2.2 1.00
134_V 148_L 2.158 1.00
30_G 317_R 2.058 1.00
142_E 146_M 2.008 1.00
57_T 135_S 1.908 1.00
41_A 45_A 1.886 1.00
46_I 50_A 1.843 1.00
118_K 136_Y 1.841 1.00
113_Q 117_E 1.772 1.00
46_I 299_L 1.745 1.00
226_Q 229_L 1.716 1.00
164_E 172_A 1.694 1.00
199_Q 203_A 1.678 1.00
226_Q 230_F 1.647 1.00
136_Y 147_K 1.624 0.99
295_K 298_T 1.587 0.99
206_Y 210_A 1.553 0.99
37_S 313_I 1.541 0.99
241_I 245_A 1.52 0.99
58_S 286_L 1.505 0.99
41_A 306_G 1.491 0.99
136_Y 148_L 1.487 0.99
49_L 302_A 1.479 0.99
27_L 311_A 1.472 0.99
49_L 52_A 1.469 0.99
202_E 206_Y 1.467 0.99
153_Q 164_E 1.467 0.99
45_A 298_T 1.46 0.99
305_L 312_G 1.455 0.99
26_Q 318_N 1.412 0.98
48_Y 298_T 1.411 0.98
302_A 306_G 1.401 0.98
38_V 307_G 1.398 0.98
201_Q 257_Q 1.391 0.98
306_G 310_G 1.39 0.98
212_V 262_L 1.385 0.98
34_I 38_V 1.385 0.98
264_D 267_S 1.373 0.98
41_A 302_A 1.358 0.97
27_L 34_I 1.356 0.97
96_I 115_E 1.352 0.97
92_Q 99_F 1.347 0.97
292_S 295_K 1.344 0.97
53_K 139_Q 1.341 0.97
131_P 281_V 1.337 0.97
50_A 299_L 1.331 0.97
55_K 292_S 1.318 0.97
238_E 241_I 1.302 0.96
194_D 198_R 1.293 0.96
237_L 241_I 1.274 0.96
42_I 307_G 1.268 0.96
301_L 319_A 1.266 0.96
119_L 136_Y 1.265 0.96
132_L 147_K 1.259 0.95
200_I 259_R 1.256 0.95
180_D 183_R 1.253 0.95
256_Y 260_Q 1.246 0.95
238_E 242_K 1.238 0.95
26_Q 315_L 1.222 0.94
49_L 295_K 1.192 0.93
43_A 47_G 1.192 0.93
55_K 137_V 1.187 0.93
90_D 99_F 1.184 0.93
30_G 314_V 1.18 0.93
303_V 307_G 1.177 0.93
311_A 315_L 1.155 0.92
98_R 102_A 1.155 0.92
224_I 227_D 1.15 0.92
137_V 291_D 1.148 0.92
47_G 51_V 1.144 0.91
58_S 145_Q 1.142 0.91
186_E 265_I 1.142 0.91
40_V 44_L 1.137 0.91
188_V 192_Q 1.136 0.91
33_T 36_I 1.134 0.91
37_S 41_A 1.129 0.91
55_K 139_Q 1.118 0.90
226_Q 231_L 1.113 0.90
74_N 223_D 1.109 0.90
52_A 55_K 1.101 0.89
58_S 287_P 1.094 0.89
194_D 258_T 1.09 0.89
183_R 187_V 1.088 0.88
166_D 277_A 1.087 0.88
100_S 105_A 1.084 0.88
300_I 303_V 1.083 0.88
199_Q 210_A 1.08 0.88
190_Q 194_D 1.076 0.88
50_A 295_K 1.075 0.88
192_Q 196_R 1.073 0.88
64_Q 132_L 1.072 0.87
227_D 234_S 1.072 0.87
182_L 268_L 1.068 0.87
300_I 304_L 1.067 0.87
313_I 317_R 1.059 0.87
42_I 299_L 1.058 0.87
61_I 131_P 1.057 0.86
242_K 246_T 1.057 0.86
97_G 101_S 1.054 0.86
115_E 136_Y 1.054 0.86
45_A 49_L 1.054 0.86
141_A 144_A 1.05 0.86
153_Q 283_K 1.047 0.86
38_V 310_G 1.047 0.86
56_W 185_Q 1.047 0.86
309_V 312_G 1.046 0.86
40_V 47_G 1.04 0.85
29_R 318_N 1.037 0.85
24_L 39_I 1.036 0.85
207_A 211_Q 1.036 0.85
166_D 276_H 1.027 0.84
175_R 178_L 1.026 0.84
205_Q 209_Q 1.025 0.84
186_E 269_K 1.023 0.84
132_L 228_T 1.018 0.84
31_K 35_I 1.014 0.83
290_R 295_K 1.012 0.83
184_T 257_Q 1.011 0.83
145_Q 287_P 1.01 0.83
41_A 309_V 1.002 0.82
263_L 266_E 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4e29A20.757799.80.646Contact Map0.44
3b8oA80.717899.80.654Contact Map0.672
3b8mA30.745499.80.657Contact Map0.544
2k1kA20.116640.60.938Contact Map0.216
2kluA10.107435.60.94Contact Map0.114
2kv5A10.095119.90.947Contact Map0.252
2k9jB10.122718.60.948Contact Map0.381
2l2tA20.119618.10.948Contact Map0.34
2kncB10.122717.80.948Contact Map0.446
4b19A10.09215.90.949Contact Map0.275
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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