May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
WZZE - Lipopolysaccharide biosynthesis protein WzzE
UniProt: P0AG00 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11295
Length: 348 (319)
Sequences: 1537
Seq/Len: 4.82
WZZE
Paralog alert: 0.68 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FEPE WZZB WZZE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
176_R 311_P 3.808 1.00
165_A 171_A 3.777 1.00
44_A 329_W 3.386 1.00
288_M 291_T 3.138 1.00
47_Y 51_A 3.094 1.00
56_S 318_D 3.052 1.00
27_W 30_K 2.765 1.00
48_T 325_L 2.739 1.00
165_A 170_D 2.664 1.00
57_S 171_A 2.621 1.00
337_G 341_A 2.567 1.00
161_V 175_L 2.567 1.00
56_S 164_I 2.415 1.00
18_D 21_G 2.359 1.00
289_L 292_L 2.32 1.00
41_A 330_G 2.273 1.00
321_R 324_F 2.264 1.00
291_T 294_V 2.248 1.00
177_Q 180_A 2.223 1.00
59_A 179_V 2.089 1.00
29_G 344_R 2.065 1.00
48_T 326_M 2.058 1.00
169_P 173_N 1.946 1.00
45_L 49_F 1.934 1.00
172_N 313_E 1.893 1.00
26_L 338_A 1.878 1.00
172_N 176_R 1.878 1.00
48_T 51_A 1.841 1.00
45_L 326_M 1.838 1.00
226_S 230_A 1.769 1.00
252_P 258_L 1.763 1.00
164_I 319_S 1.714 1.00
56_S 162_K 1.701 0.99
332_V 339_G 1.691 0.99
267_R 270_N 1.662 0.99
49_F 326_M 1.656 0.99
163_L 175_L 1.652 0.99
261_R 265_Q 1.616 0.99
40_F 333_G 1.571 0.99
291_T 295_G 1.534 0.99
183_S 187_A 1.518 0.99
234_A 242_S 1.516 0.99
37_G 334_G 1.516 0.99
93_Q 132_S 1.506 0.98
333_G 337_G 1.494 0.98
158_N 308_L 1.487 0.98
83_D 90_S 1.47 0.98
229_Q 233_I 1.435 0.98
338_A 342_L 1.431 0.98
145_N 163_L 1.421 0.97
36_M 337_G 1.41 0.97
44_A 325_L 1.389 0.97
40_F 44_A 1.389 0.97
47_Y 325_L 1.368 0.97
163_L 174_L 1.362 0.97
40_F 329_W 1.347 0.96
40_F 336_I 1.346 0.96
44_A 48_T 1.342 0.96
285_N 291_T 1.337 0.96
290_N 293_N 1.333 0.96
294_V 298_L 1.324 0.96
36_M 340_V 1.317 0.96
33_I 37_G 1.301 0.95
17_L 22_L 1.292 0.95
25_T 345_R 1.291 0.95
288_M 294_V 1.29 0.95
48_T 329_W 1.288 0.95
52_R 166_E 1.279 0.95
228_E 235_E 1.267 0.94
327_I 330_G 1.266 0.94
336_I 340_V 1.25 0.94
35_G 42_L 1.236 0.93
26_L 33_I 1.235 0.93
37_G 337_G 1.225 0.93
140_D 144_N 1.22 0.93
320_P 324_F 1.216 0.92
208_Q 211_R 1.211 0.92
158_N 181_F 1.206 0.92
308_L 324_F 1.198 0.92
54_E 164_I 1.193 0.91
322_R 325_L 1.189 0.91
330_G 334_G 1.185 0.91
319_S 322_R 1.185 0.91
61_T 167_T 1.184 0.91
153_F 156_A 1.181 0.91
15_N 161_V 1.181 0.91
51_A 321_R 1.174 0.91
46_A 50_F 1.173 0.90
284_Q 289_L 1.16 0.90
142_M 174_L 1.156 0.90
39_A 46_A 1.142 0.89
41_A 334_G 1.133 0.88
48_T 322_R 1.132 0.88
25_T 342_L 1.131 0.88
32_W 35_G 1.125 0.88
59_A 161_V 1.123 0.88
159_D 174_L 1.123 0.88
119_L 281_D 1.117 0.87
258_L 261_R 1.116 0.87
150_P 154_T 1.112 0.87
36_M 40_F 1.108 0.87
224_M 228_E 1.101 0.86
104_F 107_Q 1.101 0.86
77_Q 82_L 1.098 0.86
33_I 338_A 1.096 0.86
340_V 344_R 1.088 0.85
119_L 291_T 1.083 0.85
19_I 56_S 1.078 0.85
175_L 179_V 1.077 0.85
49_F 322_R 1.075 0.85
60_I 309_R 1.073 0.84
58_T 160_S 1.072 0.84
185_R 303_Q 1.072 0.84
320_P 325_L 1.071 0.84
145_N 165_A 1.071 0.84
32_W 36_M 1.062 0.84
133_K 138_L 1.062 0.84
327_I 331_I 1.056 0.83
23_F 38_L 1.05 0.83
336_I 339_G 1.05 0.83
58_T 139_L 1.047 0.82
54_E 319_S 1.041 0.82
325_L 332_V 1.039 0.82
101_Y 104_F 1.035 0.81
262_P 266_A 1.034 0.81
98_D 102_K 1.032 0.81
329_W 345_R 1.031 0.81
146_I 332_V 1.031 0.81
29_G 340_V 1.03 0.81
227_I 231_L 1.028 0.81
42_L 46_A 1.026 0.81
334_G 337_G 1.019 0.80
23_F 27_W 1.007 0.79
258_L 262_P 1.006 0.79
290_N 298_L 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b8oA80.758699.90.59Contact Map0.758
3b8mA30.755799.90.63Contact Map0.691
4e29A20.701199.80.671Contact Map0.594
2kluA10.086234.30.945Contact Map0.189
2k1kA20.097710.60.956Contact Map0.242
1v54M20.11497.70.959Contact Map0.466
2kncB10.09777.50.959Contact Map0.383
2yy0A40.13797.20.96Contact Map0.612
2k9jB10.09776.70.96Contact Map0.251
2pnvA20.12365.30.962Contact Map0.76
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0213 seconds.