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OPENSEQ.org
YEDS - Putative outer membrane protein YedS
UniProt: P76335 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14042
Length: 397 (367)
Sequences: 1865
Seq/Len: 5.08
YEDS
Paralog alert: 0.84 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: NMPC OMPC OMPF OMPN PHOE YEDS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_Q 99_F 3.789 1.00
156_N 168_F 3.15 1.00
217_L 257_A 2.971 1.00
35_Y 60_G 2.923 1.00
353_T 361_S 2.832 1.00
71_F 102_L 2.724 1.00
154_Y 157_N 2.718 1.00
223_N 251_E 2.675 1.00
72_T 103_G 2.643 1.00
318_Y 346_K 2.619 1.00
74_Y 101_G 2.48 1.00
264_V 306_Y 2.449 1.00
40_G 83_A 2.343 1.00
320_Q 346_K 2.337 1.00
62_K 76_Q 2.315 1.00
64_E 72_T 2.23 1.00
170_L 205_M 2.227 1.00
219_A 253_W 2.224 1.00
34_L 59_I 2.223 1.00
74_Y 111_D 2.209 1.00
63_G 75_G 2.2 1.00
356_F 362_T 2.192 1.00
39_V 363_Y 2.149 1.00
34_L 61_F 2.127 1.00
261_A 266_L 2.122 1.00
121_D 153_T 2.092 1.00
71_F 104_F 2.064 1.00
316_I 348_V 2.031 1.00
118_V 169_A 2.014 1.00
312_L 352_A 2 1.00
35_Y 78_E 1.996 1.00
272_E 298_Q 1.928 1.00
270_Y 298_Q 1.913 1.00
313_R 355_Y 1.884 1.00
114_R 149_N 1.882 1.00
152_A 174_G 1.825 1.00
37_K 58_R 1.823 1.00
90_K 95_T 1.779 1.00
74_Y 109_T 1.776 1.00
79_F 93_T 1.765 1.00
96_R 147_R 1.718 1.00
217_L 255_V 1.717 1.00
151_V 171_Q 1.712 1.00
84_N 176_N 1.704 1.00
118_V 171_Q 1.7 1.00
158_G 164_D 1.698 1.00
79_F 88_S 1.693 1.00
366_Y 387_D 1.662 0.99
97_L 116_Y 1.642 0.99
359_N 395_Y 1.608 0.99
268_A 302_V 1.602 0.99
263_N 306_Y 1.601 0.99
215_L 257_A 1.599 0.99
221_Y 251_E 1.594 0.99
78_E 96_R 1.592 0.99
308_F 314_P 1.587 0.99
148_A 151_V 1.578 0.99
58_R 96_R 1.567 0.99
4_K 8_M 1.552 0.99
111_D 115_N 1.547 0.99
66_Q 70_Q 1.542 0.99
92_N 95_T 1.539 0.99
4_K 10_V 1.528 0.99
157_N 163_V 1.512 0.99
24_V 34_L 1.509 0.99
267_A 303_V 1.504 0.99
110_F 152_A 1.501 0.99
104_F 107_N 1.494 0.99
168_F 207_T 1.493 0.98
211_F 214_G 1.492 0.98
112_Y 152_A 1.481 0.98
35_Y 76_Q 1.467 0.98
167_N 208_S 1.458 0.98
360_M 395_Y 1.445 0.98
86_P 94_A 1.435 0.98
16_A 20_N 1.429 0.98
223_N 249_T 1.426 0.98
361_S 394_V 1.425 0.98
58_R 78_E 1.384 0.97
92_N 149_N 1.379 0.97
103_G 109_T 1.375 0.97
80_N 96_R 1.366 0.97
38_V 83_A 1.365 0.97
58_R 147_R 1.361 0.97
5_V 9_L 1.36 0.97
67_I 73_G 1.354 0.97
126_T 216_S 1.348 0.97
122_V 218_G 1.345 0.97
318_Y 348_V 1.331 0.96
118_V 206_S 1.321 0.96
215_L 259_Y 1.32 0.96
299_N 321_S 1.309 0.96
219_A 255_V 1.308 0.96
254_T 271_A 1.307 0.96
264_V 268_A 1.293 0.95
211_F 215_L 1.288 0.95
65_T 357_N 1.279 0.95
65_T 360_M 1.272 0.95
221_Y 253_W 1.272 0.95
312_L 354_Y 1.266 0.95
76_Q 97_L 1.26 0.95
166_L 211_F 1.253 0.94
255_V 268_A 1.242 0.94
80_N 95_T 1.241 0.94
4_K 14_L 1.235 0.94
236_N 239_N 1.229 0.94
1_M 4_K 1.22 0.93
357_N 360_M 1.219 0.93
362_T 393_L 1.192 0.92
260_D 306_Y 1.189 0.92
4_K 9_L 1.187 0.92
307_Q 313_R 1.187 0.92
65_T 359_N 1.185 0.92
82_G 87_E 1.184 0.92
97_L 115_N 1.183 0.92
314_P 352_A 1.183 0.92
119_V 252_A 1.179 0.92
40_G 55_S 1.177 0.91
3_R 7_A 1.175 0.91
3_R 6_L 1.174 0.91
107_N 154_Y 1.173 0.91
216_S 258_K 1.171 0.91
268_A 300_F 1.166 0.91
266_L 304_A 1.163 0.91
96_R 116_Y 1.163 0.91
167_N 210_D 1.159 0.91
129_L 351_G 1.156 0.90
56_Y 95_T 1.153 0.90
170_L 207_T 1.135 0.89
258_K 267_A 1.128 0.89
148_A 202_G 1.128 0.89
89_D 95_T 1.125 0.89
114_R 147_R 1.124 0.89
260_D 307_Q 1.118 0.88
23_E 26_N 1.113 0.88
75_G 94_A 1.11 0.88
17_G 20_N 1.109 0.88
305_Q 313_R 1.107 0.88
35_Y 62_K 1.104 0.88
82_G 85_G 1.101 0.87
122_V 169_A 1.097 0.87
71_F 106_Q 1.091 0.87
59_I 79_F 1.087 0.86
41_L 363_Y 1.078 0.86
364_V 389_V 1.078 0.86
260_D 263_N 1.073 0.85
173_Q 176_N 1.07 0.85
118_V 204_G 1.069 0.85
235_L 238_R 1.058 0.84
345_V 371_L 1.055 0.84
309_D 312_L 1.049 0.84
360_M 393_L 1.046 0.83
269_M 301_E 1.042 0.83
257_A 268_A 1.042 0.83
317_A 349_D 1.04 0.83
107_N 110_F 1.039 0.83
62_K 109_T 1.038 0.83
263_N 307_Q 1.035 0.83
232_G 240_H 1.035 0.83
361_S 396_Q 1.034 0.82
301_E 319_L 1.032 0.82
210_D 216_S 1.032 0.82
119_V 220_A 1.027 0.82
37_K 396_Q 1.026 0.82
6_L 11_P 1.025 0.82
80_N 94_A 1.024 0.82
320_Q 344_L 1.021 0.81
156_N 170_L 1.017 0.81
74_Y 103_G 1.016 0.81
23_E 30_N 1.015 0.81
115_N 153_T 1.012 0.81
5_V 12_A 1.009 0.80
22_A 30_N 1.008 0.80
153_T 171_Q 1.008 0.80
345_V 369_N 1.007 0.80
251_E 274_R 1.005 0.80
5_V 10_V 1.004 0.80
296_K 322_K 1.004 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j1nA30.86151000.21Contact Map0.716
3nsgA30.84891000.225Contact Map0.73
2zfgA10.83881000.229Contact Map0.686
1phoA10.82871000.233Contact Map0.677
2fgqX10.77081000.258Contact Map0.719
4auiA30.78341000.263Contact Map0.743
3vy8X10.84131000.284Contact Map0.706
3prnA10.68261000.36Contact Map0.512
2porA10.73051000.363Contact Map0.526
2o4vA30.864980.882Contact Map0.585
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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