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OPENSEQ.org
OMPC - Outer membrane protein C
UniProt: P06996 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10670
Length: 367 (353)
Sequences: 2406
Seq/Len: 6.82
OMPC
Paralog alert: 0.84 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: NMPC OMPC OMPF OMPN PHOE YEDS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_Q 98_F 4.12 1.00
298_Y 317_K 3.103 1.00
72_T 102_K 3.097 1.00
35_Y 60_G 3.095 1.00
63_G 75_G 3.092 1.00
154_N 166_F 3.061 1.00
71_L 101_L 2.916 1.00
214_I 246_L 2.849 1.00
324_T 332_S 2.788 1.00
64_E 72_T 2.657 1.00
152_Y 155_T 2.631 1.00
220_S 240_E 2.578 1.00
74_Y 100_G 2.528 1.00
74_Y 110_D 2.523 1.00
253_I 286_Y 2.522 1.00
40_G 83_G 2.436 1.00
292_L 323_A 2.423 1.00
216_G 242_Y 2.279 1.00
300_Q 317_K 2.265 1.00
34_L 59_L 2.264 1.00
327_F 333_T 2.234 1.00
250_A 255_L 2.211 1.00
120_D 151_T 2.19 1.00
34_L 61_F 2.154 1.00
62_K 76_Q 2.135 1.00
168_V 203_G 2.077 1.00
149_F 169_Q 2.061 1.00
35_Y 78_E 2.051 1.00
67_V 73_G 2.015 1.00
166_F 205_I 1.991 1.00
39_D 334_Y 1.987 1.00
293_R 326_Y 1.979 1.00
91_N 147_N 1.957 1.00
259_Y 278_Q 1.926 1.00
117_V 167_A 1.919 1.00
66_Q 70_Q 1.919 1.00
71_L 103_F 1.918 1.00
113_R 147_N 1.877 1.00
74_Y 108_S 1.845 1.00
84_N 174_N 1.835 1.00
109_F 150_A 1.822 1.00
38_V 83_G 1.82 1.00
332_S 364_V 1.783 1.00
37_K 58_R 1.783 1.00
296_L 319_V 1.775 1.00
58_R 78_E 1.762 1.00
252_N 286_Y 1.75 1.00
96_V 115_Y 1.7 1.00
79_Y 92_S 1.697 1.00
156_D 162_D 1.692 1.00
261_Q 278_Q 1.69 1.00
78_E 95_R 1.675 1.00
91_N 94_T 1.671 1.00
117_V 169_Q 1.615 1.00
155_T 161_V 1.599 1.00
111_Y 150_A 1.593 1.00
333_T 363_L 1.592 1.00
212_F 248_Y 1.585 1.00
58_R 95_R 1.582 1.00
337_Y 357_N 1.58 1.00
80_Q 95_R 1.561 1.00
150_A 172_G 1.557 0.99
298_Y 319_V 1.554 0.99
292_L 325_Y 1.523 0.99
89_E 94_T 1.514 0.99
330_N 365_Y 1.512 0.99
125_T 213_G 1.497 0.99
331_M 365_Y 1.493 0.99
256_A 283_V 1.489 0.99
214_I 244_G 1.485 0.99
216_G 244_G 1.483 0.99
212_F 246_L 1.482 0.99
165_N 206_T 1.462 0.99
82_Q 87_E 1.461 0.99
218_I 240_E 1.46 0.99
35_Y 76_Q 1.449 0.99
110_D 114_N 1.428 0.99
121_V 215_G 1.428 0.99
59_L 79_Y 1.42 0.99
96_V 114_N 1.417 0.99
71_L 105_D 1.402 0.99
4_K 8_L 1.398 0.99
288_F 294_P 1.392 0.99
154_N 161_V 1.391 0.99
71_L 106_V 1.37 0.98
16_A 20_N 1.366 0.98
86_A 93_W 1.363 0.98
257_A 282_A 1.36 0.98
95_R 145_R 1.355 0.98
65_T 328_N 1.35 0.98
146_G 200_G 1.344 0.98
58_R 145_R 1.338 0.98
103_F 106_V 1.337 0.98
102_K 108_S 1.31 0.98
146_G 149_F 1.309 0.98
297_A 320_D 1.303 0.98
74_Y 102_K 1.29 0.97
220_S 238_R 1.279 0.97
80_Q 94_T 1.275 0.97
39_D 52_G 1.274 0.97
218_I 242_Y 1.257 0.97
285_Q 293_R 1.252 0.97
165_N 208_D 1.252 0.97
82_Q 85_S 1.245 0.97
294_P 323_A 1.241 0.97
253_I 257_A 1.23 0.96
106_V 152_Y 1.227 0.96
287_Q 293_R 1.222 0.96
110_D 153_R 1.222 0.96
117_V 204_S 1.217 0.96
76_Q 96_V 1.211 0.96
164_L 209_Y 1.21 0.96
247_K 256_A 1.2 0.96
249_D 252_N 1.2 0.96
128_L 322_G 1.197 0.95
23_E 30_N 1.196 0.95
24_V 34_L 1.188 0.95
35_Y 62_K 1.183 0.95
332_S 366_Q 1.18 0.95
110_D 151_T 1.179 0.95
118_V 241_T 1.178 0.95
243_T 260_T 1.176 0.95
74_Y 98_F 1.174 0.95
3_V 6_L 1.168 0.95
106_V 109_F 1.167 0.95
291_G 326_Y 1.164 0.94
149_F 171_Q 1.16 0.94
56_Y 94_T 1.158 0.94
208_D 213_G 1.157 0.94
65_T 330_N 1.146 0.94
289_D 292_L 1.142 0.94
79_Y 88_N 1.137 0.94
213_G 247_K 1.131 0.93
328_N 331_M 1.13 0.93
72_T 104_Q 1.129 0.93
65_T 331_M 1.119 0.93
169_Q 202_G 1.114 0.93
255_L 284_A 1.11 0.92
211_G 248_Y 1.107 0.92
118_V 217_A 1.102 0.92
37_K 366_Q 1.1 0.92
316_L 340_N 1.099 0.92
4_K 10_V 1.093 0.92
249_D 286_Y 1.093 0.92
4_K 7_S 1.087 0.91
71_L 104_Q 1.081 0.91
4_K 14_L 1.081 0.91
171_Q 174_N 1.074 0.91
17_G 20_N 1.066 0.90
41_L 53_D 1.064 0.90
1_M 4_K 1.062 0.90
4_K 9_L 1.06 0.90
2_K 5_V 1.055 0.90
302_K 315_I 1.055 0.90
23_E 26_N 1.051 0.89
11_P 17_G 1.05 0.89
284_A 296_L 1.048 0.89
151_T 169_Q 1.047 0.89
249_D 287_Q 1.047 0.89
7_S 10_V 1.045 0.89
300_Q 315_I 1.034 0.88
209_Y 212_F 1.028 0.88
247_K 254_Y 1.027 0.88
362_G 367_F 1.027 0.88
258_Q 281_E 1.025 0.88
34_L 97_A 1.023 0.88
19_A 22_A 1.006 0.87
114_N 151_T 1.005 0.86
62_K 108_S 1 0.86
154_N 163_G 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j1nA30.94281000.219Contact Map0.702
3nsgA30.89921000.24Contact Map0.74
2zfgA10.88831000.255Contact Map0.684
1phoA10.88561000.259Contact Map0.673
4auiA30.8421000.295Contact Map0.777
2fgqX10.83111000.295Contact Map0.738
3vy8X10.88831000.319Contact Map0.743
3prnA10.73571000.392Contact Map0.518
2porA10.76571000.393Contact Map0.533
2o4vA30.893798.50.862Contact Map0.583
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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