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PAAA - 1,2-phenylacetyl-CoA epoxidase, subunit A
UniProt: P76077 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13736
Length: 309 (308)
Sequences: 419
Seq/Len: 1.36

PAAA
Paralog alert: 0.74 [within 20: 0.46] - ratio of genomes with paralogs
Cluster includes: PAAA PAAC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_A 80_Y 3.014 1.00
8_E 12_A 2.855 1.00
290_T 294_E 2.589 1.00
4_E 8_E 2.526 1.00
266_E 271_R 2.488 1.00
180_L 238_M 2.474 1.00
44_V 47_L 2.304 0.99
120_V 180_L 2.199 0.99
36_G 102_M 2.14 0.99
94_Y 98_L 2.074 0.98
170_A 180_L 1.994 0.97
124_L 184_I 1.982 0.97
284_K 288_E 1.915 0.97
251_S 255_R 1.81 0.95
184_I 238_M 1.806 0.95
5_E 9_Q 1.765 0.94
120_V 238_M 1.753 0.94
248_D 255_R 1.75 0.94
127_G 159_Q 1.707 0.92
10_R 15_T 1.701 0.92
169_L 180_L 1.656 0.91
166_C 180_L 1.653 0.91
283_R 287_E 1.649 0.91
174_E 178_Q 1.649 0.91
247_F 251_S 1.622 0.90
177_K 238_M 1.62 0.90
131_V 228_N 1.579 0.88
1_M 4_E 1.556 0.87
98_L 283_R 1.548 0.87
53_I 69_V 1.529 0.86
189_W 257_G 1.514 0.85
205_S 217_T 1.49 0.84
1_M 5_E 1.485 0.83
170_A 238_M 1.477 0.83
94_Y 283_R 1.464 0.82
79_L 133_Q 1.456 0.82
247_F 255_R 1.451 0.81
284_K 305_A 1.437 0.80
79_L 144_Y 1.432 0.80
9_Q 13_Q 1.408 0.79
16_A 286_W 1.407 0.78
169_L 238_M 1.379 0.77
181_Q 185_N 1.367 0.76
265_N 269_N 1.36 0.75
118_I 165_A 1.357 0.75
2_T 307_K 1.33 0.73
46_M 296_A 1.324 0.72
200_D 203_P 1.318 0.72
11_I 17_I 1.318 0.72
290_T 301_Q 1.311 0.71
273_I 282_K 1.31 0.71
133_Q 161_Q 1.31 0.71
246_H 301_Q 1.267 0.67
265_N 268_I 1.26 0.67
166_C 170_A 1.258 0.67
262_Q 266_E 1.245 0.66
94_Y 303_Q 1.245 0.66
99_D 271_R 1.234 0.65
189_W 259_I 1.227 0.64
212_K 269_N 1.221 0.63
14_E 296_A 1.218 0.63
16_A 276_Q 1.216 0.63
10_R 14_E 1.203 0.62
215_R 296_A 1.2 0.61
64_I 169_L 1.192 0.61
277_E 281_A 1.191 0.60
299_H 303_Q 1.19 0.60
163_F 232_Q 1.188 0.60
276_Q 303_Q 1.187 0.60
145_A 187_F 1.186 0.60
60_R 164_E 1.178 0.59
56_A 115_W 1.175 0.59
13_Q 139_T 1.171 0.59
11_I 277_E 1.168 0.58
171_Q 237_G 1.16 0.57
77_L 90_R 1.159 0.57
281_A 286_W 1.159 0.57
271_R 277_E 1.153 0.57
167_M 235_M 1.152 0.57
130_I 152_C 1.15 0.56
120_V 165_A 1.144 0.56
44_V 281_A 1.139 0.55
4_E 297_L 1.125 0.54
6_R 269_N 1.12 0.53
11_I 212_K 1.117 0.53
244_D 257_G 1.115 0.53
222_R 226_V 1.115 0.53
16_A 281_A 1.114 0.53
79_L 161_Q 1.112 0.53
276_Q 280_D 1.103 0.52
287_E 304_H 1.099 0.51
94_Y 286_W 1.097 0.51
177_K 237_G 1.093 0.51
170_A 177_K 1.092 0.51
96_K 279_L 1.089 0.50
268_I 297_L 1.088 0.50
35_I 86_L 1.087 0.50
126_D 129_A 1.085 0.50
41_S 253_H 1.081 0.50
126_D 133_Q 1.08 0.49
203_P 303_Q 1.079 0.49
76_G 90_R 1.078 0.49
9_Q 15_T 1.077 0.49
139_T 217_T 1.077 0.49
126_D 162_G 1.076 0.49
180_L 184_I 1.076 0.49
1_M 308_V 1.076 0.49
10_R 20_Q 1.075 0.49
281_A 284_K 1.073 0.49
26_A 274_C 1.072 0.49
284_K 304_H 1.071 0.49
5_E 301_Q 1.067 0.48
37_Q 198_N 1.064 0.48
143_P 155_E 1.063 0.48
284_K 297_L 1.061 0.48
288_E 305_A 1.06 0.47
60_R 91_E 1.058 0.47
6_R 10_R 1.055 0.47
77_L 160_R 1.05 0.46
16_A 20_Q 1.048 0.46
273_I 303_Q 1.048 0.46
47_L 281_A 1.045 0.46
114_S 183_A 1.041 0.46
91_E 173_S 1.039 0.45
4_E 12_A 1.037 0.45
262_Q 304_H 1.034 0.45
9_Q 277_E 1.031 0.45
262_Q 265_N 1.025 0.44
200_D 277_E 1.023 0.44
61_R 161_Q 1.019 0.43
12_A 271_R 1.019 0.43
227_D 253_H 1.016 0.43
268_I 301_Q 1.013 0.43
43_I 300_A 1.013 0.43
200_D 276_Q 1.012 0.43
81_S 90_R 1.012 0.43
261_W 264_F 1.01 0.42
6_R 301_Q 1.008 0.42
139_T 201_N 1.007 0.42
303_Q 306_R 1.007 0.42
5_E 8_E 1.005 0.42
280_D 297_L 1.002 0.42
114_S 117_D 1.001 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pvtA10.99681000.228Contact Map0.488
1otkA20.79941000.329Contact Map0.505
3pf7A20.96761000.384Contact Map0.24
4mudA40.74431000.49Contact Map0.585
1mtyB20.773597.10.935Contact Map0.377
3ge3A10.93297.10.935Contact Map0.335
2incA10.9288970.936Contact Map0.384
1mhyB10.799496.90.936Contact Map0.336
3u52A20.948296.70.938Contact Map0.456
3u52C20.7379960.943Contact Map0.566

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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