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OPENSEQ.org
YBIP - Putative phosphoethanolamine transferase YbiP
UniProt: P75785 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13321
Length: 527 (476)
Sequences: 647
Seq/Len: 1.36
YBIP
Paralog alert: 0.58 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EPTA EPTB EPTC YBIP YHBX YJGX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
222_V 401_L 4.002 1.00
366_S 393_T 3.902 1.00
233_G 242_T 3.838 1.00
285_F 477_F 3.775 1.00
304_Q 308_Y 3.466 1.00
235_F 252_I 3.428 1.00
476_F 495_I 3.359 1.00
406_D 409_R 3.081 1.00
375_Q 396_Q 2.769 1.00
380_T 395_T 2.613 1.00
346_A 407_Q 2.592 1.00
289_A 481_T 2.391 0.99
475_G 492_Y 2.391 0.99
420_F 470_A 2.389 0.99
404_L 417_L 2.329 0.99
400_L 404_L 2.234 0.99
244_F 399_D 2.041 0.98
256_Y 468_R 1.94 0.97
230_D 445_Q 1.934 0.97
218_T 413_S 1.893 0.96
219_Y 416_S 1.891 0.96
248_V 402_R 1.87 0.96
227_A 394_M 1.86 0.96
227_A 232_L 1.847 0.96
221_V 358_L 1.816 0.95
308_Y 443_Y 1.772 0.94
361_L 404_L 1.765 0.94
221_V 420_F 1.764 0.94
221_V 473_F 1.753 0.94
219_Y 358_L 1.735 0.93
232_L 363_L 1.732 0.93
339_E 396_Q 1.68 0.92
401_L 417_L 1.625 0.90
157_P 161_L 1.624 0.90
78_F 104_I 1.605 0.89
488_I 493_P 1.584 0.88
89_T 92_A 1.557 0.87
307_E 443_Y 1.556 0.87
240_D 246_S 1.536 0.86
416_S 459_K 1.53 0.86
227_A 397_T 1.53 0.86
479_Q 493_P 1.514 0.85
479_Q 488_I 1.513 0.85
227_A 366_S 1.496 0.84
244_F 402_R 1.491 0.84
240_D 395_T 1.477 0.83
275_V 443_Y 1.474 0.83
307_E 312_I 1.462 0.82
310_T 443_Y 1.458 0.82
227_A 421_S 1.453 0.81
162_A 307_E 1.452 0.81
257_I 447_F 1.451 0.81
234_A 252_I 1.446 0.81
233_G 246_S 1.444 0.81
197_M 283_D 1.435 0.80
459_K 476_F 1.422 0.79
478_S 485_A 1.417 0.79
308_Y 312_I 1.411 0.79
378_Y 399_D 1.406 0.78
379_E 382_V 1.404 0.78
206_T 443_Y 1.399 0.78
370_A 425_L 1.399 0.78
289_A 477_F 1.374 0.76
103_E 369_Q 1.372 0.76
309_D 312_I 1.366 0.76
219_Y 294_F 1.355 0.75
292_A 481_T 1.347 0.74
222_V 417_L 1.347 0.74
162_A 308_Y 1.345 0.74
233_G 240_D 1.343 0.74
374_T 392_Y 1.34 0.74
309_D 313_A 1.335 0.73
305_I 308_Y 1.333 0.73
435_Q 441_D 1.329 0.73
205_D 309_D 1.327 0.73
241_N 391_L 1.321 0.72
220_V 404_L 1.319 0.72
314_S 318_R 1.313 0.71
339_E 375_Q 1.311 0.71
239_W 391_L 1.311 0.71
420_F 473_F 1.303 0.71
229_R 252_I 1.302 0.71
221_V 360_V 1.3 0.70
325_L 443_Y 1.295 0.70
215_K 414_S 1.281 0.69
218_T 349_L 1.28 0.69
309_D 443_Y 1.28 0.69
77_P 235_F 1.277 0.68
346_A 350_A 1.276 0.68
103_E 364_M 1.27 0.68
255_D 467_R 1.269 0.68
275_V 325_L 1.268 0.68
274_V 310_T 1.262 0.67
468_R 494_F 1.256 0.67
162_A 310_T 1.255 0.66
91_L 302_Q 1.253 0.66
116_G 121_A 1.233 0.64
342_L 407_Q 1.232 0.64
90_L 159_Q 1.225 0.64
290_N 320_D 1.221 0.63
294_F 481_T 1.22 0.63
289_A 294_F 1.22 0.63
69_S 124_V 1.219 0.63
307_E 310_T 1.214 0.63
228_R 266_S 1.211 0.62
261_G 298_W 1.205 0.62
386_E 389_C 1.205 0.62
270_T 473_F 1.194 0.61
220_V 345_T 1.193 0.61
366_S 394_M 1.191 0.60
231_A 445_Q 1.19 0.60
223_I 267_L 1.184 0.60
220_V 361_L 1.183 0.60
275_V 464_I 1.182 0.60
440_D 483_I 1.181 0.59
74_C 112_S 1.178 0.59
245_A 452_M 1.176 0.59
259_A 269_L 1.173 0.59
375_Q 399_D 1.172 0.59
237_G 391_L 1.17 0.58
289_A 358_L 1.169 0.58
310_T 314_S 1.169 0.58
103_E 372_D 1.166 0.58
307_E 325_L 1.165 0.58
233_G 241_N 1.164 0.58
453_V 476_F 1.161 0.58
453_V 482_G 1.159 0.57
342_L 346_A 1.159 0.57
308_Y 325_L 1.158 0.57
299_F 344_M 1.145 0.56
391_L 454_I 1.14 0.55
337_K 417_L 1.14 0.55
375_Q 378_Y 1.135 0.55
84_A 441_D 1.135 0.55
374_T 393_T 1.13 0.54
337_K 375_Q 1.13 0.54
305_I 443_Y 1.129 0.54
162_A 443_Y 1.127 0.54
162_A 309_D 1.126 0.54
252_I 452_M 1.124 0.54
201_S 485_A 1.121 0.54
363_L 400_L 1.12 0.53
288_L 291_R 1.119 0.53
229_R 448_Q 1.116 0.53
105_L 292_A 1.113 0.53
304_Q 443_Y 1.11 0.52
308_Y 311_A 1.11 0.52
374_T 379_E 1.108 0.52
246_S 460_A 1.108 0.52
344_M 349_L 1.108 0.52
116_G 393_T 1.107 0.52
440_D 446_N 1.105 0.52
275_V 307_E 1.103 0.52
83_G 394_M 1.103 0.52
119_I 163_W 1.102 0.52
310_T 325_L 1.102 0.52
296_T 311_A 1.098 0.51
275_V 308_Y 1.096 0.51
231_A 387_T 1.091 0.51
231_A 391_L 1.09 0.50
242_T 246_S 1.088 0.50
71_V 74_C 1.087 0.50
376_G 379_E 1.086 0.50
161_L 302_Q 1.085 0.50
208_T 483_I 1.082 0.50
344_M 347_Q 1.08 0.49
178_R 284_N 1.08 0.49
104_I 363_L 1.072 0.49
273_R 487_E 1.071 0.49
397_T 401_L 1.07 0.48
220_V 408_L 1.069 0.48
400_L 494_F 1.068 0.48
178_R 308_Y 1.067 0.48
62_K 443_Y 1.067 0.48
433_D 445_Q 1.067 0.48
378_Y 396_Q 1.062 0.48
62_K 66_G 1.058 0.47
205_D 274_V 1.054 0.47
371_C 389_C 1.053 0.47
229_R 360_V 1.052 0.47
163_W 443_Y 1.051 0.47
208_T 356_P 1.05 0.46
209_V 482_G 1.049 0.46
227_A 242_T 1.048 0.46
347_Q 350_A 1.047 0.46
248_V 406_D 1.045 0.46
396_Q 399_D 1.045 0.46
88_N 495_I 1.044 0.46
295_Q 355_Q 1.041 0.46
316_A 321_E 1.04 0.45
179_F 223_I 1.037 0.45
257_I 444_Q 1.035 0.45
139_N 176_V 1.034 0.45
453_V 477_F 1.034 0.45
339_E 403_K 1.031 0.45
232_L 393_T 1.029 0.44
270_T 420_F 1.026 0.44
233_G 245_A 1.026 0.44
219_Y 477_F 1.026 0.44
63_V 66_G 1.025 0.44
82_Y 417_L 1.025 0.44
90_L 186_N 1.023 0.44
308_Y 331_E 1.02 0.43
301_N 373_R 1.019 0.43
131_K 410_N 1.019 0.43
264_Q 440_D 1.019 0.43
275_V 310_T 1.016 0.43
321_E 324_F 1.014 0.43
337_K 364_M 1.014 0.43
74_C 116_G 1.012 0.43
379_E 386_E 1.01 0.42
145_C 152_T 1.01 0.42
85_P 256_Y 1.006 0.42
305_I 325_L 1.005 0.42
127_I 150_V 1.004 0.42
312_I 316_A 1.002 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kavA10.56361000.721Contact Map0.75
2w8dA20.63381000.797Contact Map0.548
3b5qA20.59961000.799Contact Map0.581
2w5qA10.62241000.802Contact Map0.555
2vqrA10.63571000.806Contact Map0.651
3lxqA20.69641000.807Contact Map0.598
3ed4A40.64141000.807Contact Map0.614
2qzuA10.63381000.808Contact Map0.572
1fsuA10.58821000.817Contact Map0.643
1aukA10.58441000.82Contact Map0.574
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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