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YBHI - Inner membrane protein YbhI
UniProt: P75763 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13665
Length: 477 (459)
Sequences: 3641
Seq/Len: 7.93
YBHI
Paralog alert: 0.68 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ARSB CITT TTDT YBHI YBIR YFJV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_T 316_D 4.171 1.00
123_T 126_G 3.707 1.00
260_G 263_E 3.503 1.00
347_E 351_E 3.489 1.00
72_S 80_A 3.297 1.00
80_A 342_K 3.027 1.00
102_A 306_M 2.623 1.00
281_A 302_V 2.534 1.00
441_D 444_S 2.469 1.00
180_M 434_I 2.431 1.00
195_F 205_L 2.264 1.00
313_T 316_D 2.254 1.00
181_M 185_M 2.254 1.00
217_S 220_G 2.23 1.00
135_D 153_V 2.153 1.00
222_A 226_G 2.126 1.00
230_I 234_L 2.06 1.00
38_I 63_A 2.054 1.00
115_L 118_G 2.053 1.00
443_K 447_L 2.052 1.00
42_A 60_A 2.025 1.00
94_F 327_L 1.951 1.00
115_L 119_K 1.905 1.00
98_T 303_M 1.891 1.00
454_I 458_L 1.884 1.00
137_V 141_A 1.881 1.00
361_G 364_N 1.814 1.00
131_T 157_I 1.791 1.00
36_F 345_F 1.785 1.00
33_W 37_G 1.773 1.00
85_Y 331_G 1.755 1.00
277_V 305_T 1.752 1.00
380_F 453_T 1.749 1.00
315_E 320_N 1.748 1.00
129_Y 237_P 1.738 1.00
242_T 245_P 1.72 1.00
418_S 421_G 1.718 1.00
272_K 276_G 1.676 1.00
287_F 291_L 1.669 1.00
444_S 447_L 1.668 1.00
139_A 190_T 1.667 1.00
196_T 218_W 1.646 1.00
259_A 263_E 1.641 1.00
94_F 98_T 1.633 1.00
17_C 21_F 1.629 1.00
41_A 45_G 1.614 1.00
177_H 444_S 1.593 1.00
38_I 64_S 1.587 1.00
132_V 186_V 1.584 1.00
209_N 215_Q 1.582 1.00
184_Y 434_I 1.577 1.00
144_S 148_R 1.576 1.00
64_S 339_L 1.571 1.00
219_G 223_L 1.568 1.00
340_L 345_F 1.567 1.00
283_L 287_F 1.556 1.00
280_L 284_G 1.541 1.00
235_V 459_V 1.533 1.00
102_A 274_L 1.533 1.00
45_G 48_I 1.531 1.00
425_H 435_F 1.526 1.00
51_F 55_V 1.522 1.00
228_P 459_V 1.52 1.00
32_A 345_F 1.509 1.00
446_W 450_A 1.504 1.00
277_V 306_M 1.503 1.00
44_V 48_I 1.482 0.99
38_I 60_A 1.48 0.99
220_G 223_L 1.479 0.99
95_S 299_A 1.47 0.99
136_L 229_G 1.455 0.99
352_V 356_N 1.447 0.99
287_F 290_S 1.437 0.99
276_G 280_L 1.436 0.99
30_E 34_V 1.433 0.99
223_L 227_L 1.43 0.99
45_G 56_V 1.427 0.99
193_M 226_G 1.42 0.99
238_L 242_T 1.419 0.99
157_I 183_I 1.413 0.99
348_W 352_V 1.412 0.99
10_I 14_A 1.41 0.99
259_A 262_A 1.399 0.99
52_P 56_V 1.398 0.99
193_M 229_G 1.391 0.99
376_I 453_T 1.388 0.99
465_V 469_N 1.386 0.99
41_A 63_A 1.383 0.99
101_A 104_V 1.375 0.99
227_L 230_I 1.371 0.99
269_I 273_M 1.358 0.99
200_G 428_G 1.35 0.99
277_V 302_V 1.35 0.99
120_I 130_V 1.349 0.99
62_A 304_A 1.344 0.99
189_T 232_M 1.333 0.99
38_I 42_A 1.329 0.99
190_T 197_A 1.328 0.99
121_G 126_G 1.326 0.98
443_K 446_W 1.322 0.98
42_A 56_V 1.318 0.98
415_F 418_S 1.315 0.98
15_I 44_V 1.304 0.98
32_A 348_W 1.302 0.98
61_V 82_L 1.299 0.98
343_V 393_P 1.297 0.98
235_V 455_L 1.295 0.98
395_F 413_L 1.293 0.98
95_S 303_M 1.284 0.98
450_A 454_I 1.274 0.98
99_L 281_A 1.256 0.98
111_R 114_Y 1.254 0.98
220_G 407_M 1.248 0.98
189_T 236_T 1.244 0.97
351_E 355_N 1.241 0.97
232_M 456_T 1.241 0.97
125_L 241_Y 1.241 0.97
385_S 428_G 1.237 0.97
19_I 37_G 1.232 0.97
373_L 457_F 1.219 0.97
332_G 336_L 1.215 0.97
118_G 258_K 1.212 0.97
11_L 15_I 1.204 0.97
199_A 385_S 1.199 0.97
256_I 259_A 1.199 0.97
191_S 194_F 1.199 0.97
16_P 20_G 1.198 0.97
412_A 464_G 1.195 0.97
360_D 364_N 1.194 0.97
65_M 81_V 1.184 0.96
264_L 271_E 1.183 0.96
388_I 417_N 1.183 0.96
140_P 193_M 1.183 0.96
351_E 354_K 1.176 0.96
268_K 271_E 1.175 0.96
90_T 327_L 1.173 0.96
238_L 241_Y 1.172 0.96
111_R 115_L 1.171 0.96
35_L 64_S 1.17 0.96
61_V 332_G 1.169 0.96
280_L 305_T 1.162 0.96
231_I 459_V 1.157 0.96
190_T 194_F 1.154 0.96
34_V 68_V 1.154 0.96
340_L 346_F 1.152 0.96
373_L 377_V 1.151 0.95
279_V 283_L 1.147 0.95
239_V 455_L 1.146 0.95
58_L 328_I 1.146 0.95
423_V 450_A 1.138 0.95
111_R 271_E 1.137 0.95
191_S 197_A 1.133 0.95
306_M 310_G 1.132 0.95
34_V 70_N 1.131 0.95
234_L 238_L 1.13 0.95
253_N 256_I 1.13 0.95
45_G 59_I 1.124 0.95
191_S 198_M 1.123 0.95
89_T 93_V 1.122 0.95
29_S 32_A 1.122 0.95
93_V 385_S 1.121 0.95
352_V 355_N 1.118 0.94
377_V 381_F 1.117 0.94
19_I 40_L 1.117 0.94
7_W 10_I 1.117 0.94
397_M 400_N 1.115 0.94
200_G 385_S 1.114 0.94
444_S 448_V 1.111 0.94
68_V 71_L 1.111 0.94
46_L 333_I 1.11 0.94
295_E 299_A 1.107 0.94
135_D 187_T 1.105 0.94
330_Y 385_S 1.105 0.94
147_A 221_W 1.105 0.94
377_V 450_A 1.102 0.94
284_G 301_V 1.101 0.94
106_T 274_L 1.098 0.94
39_Y 340_L 1.096 0.94
15_I 18_I 1.096 0.94
194_F 197_A 1.094 0.94
265_G 271_E 1.093 0.94
378_R 387_Y 1.093 0.94
180_M 440_N 1.092 0.94
396_A 400_N 1.091 0.94
93_V 330_Y 1.09 0.93
73_D 79_T 1.088 0.93
284_G 298_V 1.088 0.93
184_Y 430_A 1.081 0.93
134_L 153_V 1.064 0.92
63_A 68_V 1.064 0.92
275_L 279_V 1.064 0.92
110_K 114_Y 1.061 0.92
379_Y 384_G 1.061 0.92
154_L 433_V 1.061 0.92
8_K 12_I 1.061 0.92
23_P 26_A 1.057 0.92
54_P 325_N 1.055 0.92
184_Y 431_G 1.055 0.92
14_A 19_I 1.051 0.92
200_G 388_I 1.049 0.92
367_F 461_I 1.045 0.91
54_P 318_V 1.045 0.91
146_T 198_M 1.043 0.91
362_H 366_A 1.043 0.91
125_L 237_P 1.043 0.91
144_S 147_A 1.042 0.91
35_L 339_L 1.042 0.91
145_N 148_R 1.04 0.91
101_A 321_K 1.038 0.91
196_T 199_A 1.035 0.91
21_F 24_A 1.035 0.91
363_G 465_V 1.035 0.91
364_N 367_F 1.033 0.91
92_L 145_N 1.032 0.91
53_E 57_L 1.031 0.91
460_H 464_G 1.03 0.91
273_M 309_L 1.028 0.91
341_S 347_E 1.025 0.90
186_V 190_T 1.023 0.90
199_A 428_G 1.023 0.90
338_S 342_K 1.015 0.90
462_T 465_V 1.015 0.90
416_S 420_G 1.012 0.90
139_A 191_S 1.012 0.90
12_I 45_G 1.01 0.90
11_L 17_C 1.007 0.89
383_S 386_A 1.007 0.89
51_F 56_V 1.006 0.89
206_K 210_D 1.005 0.89
415_F 420_G 1.005 0.89
40_L 44_V 1.004 0.89
221_W 414_L 1.003 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.92031000.403Contact Map0.676
2rddB10.07554.60.976Contact Map0.627
1q90R10.06713.10.978Contact Map0.375
2nwlA30.48222.60.979Contact Map0.269
2ksfA10.22012.50.979Contact Map0.123
3ar4A10.12792.40.979Contact Map0.353
1ldfA10.51362.30.979Contact Map0.283
2kncA10.1092.20.98Contact Map0.471
1pi7A10.07551.80.981Contact Map0.631
2m20A20.12371.70.981Contact Map0.201
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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