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OPENSEQ.org
CITT - Citrate carrier
UniProt: P0AE74 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13538
Length: 487 (463)
Sequences: 3545
Seq/Len: 7.66
CITT
Paralog alert: 0.71 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ARSB CITT TTDT YBHI YBIR YFJV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
119_V 331_D 4.084 1.00
362_D 366_G 3.577 1.00
137_R 140_T 3.497 1.00
276_E 279_T 3.287 1.00
81_A 89_K 3.118 1.00
89_K 357_R 2.904 1.00
195_M 449_I 2.587 1.00
116_G 321_M 2.547 1.00
456_K 459_D 2.488 1.00
210_V 220_L 2.399 1.00
297_S 317_A 2.346 1.00
196_W 200_I 2.325 1.00
232_S 235_Q 2.249 1.00
458_K 462_R 2.162 1.00
149_D 167_V 2.15 1.00
151_L 155_F 2.079 1.00
44_M 62_A 2.067 1.00
237_F 241_L 2.057 1.00
328_P 331_D 2.049 1.00
433_G 436_G 1.966 1.00
245_V 249_I 1.954 1.00
129_F 132_K 1.954 1.00
40_V 65_I 1.938 1.00
38_F 360_F 1.907 1.00
303_F 307_V 1.903 1.00
108_F 342_L 1.902 1.00
112_I 318_V 1.896 1.00
129_F 133_F 1.88 1.00
271_T 275_D 1.874 1.00
257_V 260_K 1.869 1.00
143_Y 252_P 1.866 1.00
469_V 473_S 1.857 1.00
299_G 303_F 1.81 1.00
145_I 171_I 1.8 1.00
394_L 468_G 1.774 1.00
275_D 278_K 1.772 1.00
40_V 66_C 1.771 1.00
35_W 39_A 1.753 1.00
99_F 346_A 1.727 1.00
275_D 279_T 1.717 1.00
108_F 112_I 1.702 1.00
43_A 47_G 1.691 1.00
211_T 233_W 1.685 1.00
285_R 289_T 1.677 1.00
116_G 290_L 1.667 1.00
293_L 320_L 1.651 1.00
66_C 354_G 1.64 1.00
234_L 238_L 1.627 1.00
376_S 379_A 1.623 1.00
146_V 201_S 1.598 1.00
440_P 450_Y 1.598 1.00
293_L 321_M 1.588 1.00
459_D 462_R 1.571 1.00
34_A 360_F 1.565 1.00
224_S 230_Q 1.561 1.00
461_W 465_A 1.548 1.00
153_A 205_S 1.544 1.00
17_V 46_V 1.539 1.00
47_G 50_L 1.535 1.00
158_S 162_R 1.534 1.00
355_L 360_F 1.533 1.00
243_V 474_M 1.521 1.00
192_G 459_D 1.513 1.00
430_L 433_G 1.506 0.99
250_I 474_M 1.499 0.99
253_W 257_V 1.499 0.99
363_W 367_T 1.492 0.99
208_M 241_L 1.484 0.99
19_G 23_L 1.483 0.99
390_F 468_G 1.478 0.99
46_V 50_L 1.467 0.99
288_W 292_G 1.464 0.99
150_I 244_G 1.46 0.99
40_V 62_A 1.451 0.99
480_W 484_A 1.448 0.99
199_V 449_I 1.442 0.99
367_T 371_H 1.441 0.99
208_M 244_G 1.441 0.99
12_L 16_V 1.436 0.99
235_Q 238_L 1.435 0.99
53_I 57_A 1.428 0.99
215_P 443_T 1.416 0.99
132_K 274_G 1.415 0.99
109_G 314_G 1.409 0.99
238_L 242_P 1.403 0.99
13_A 17_V 1.4 0.99
268_E 271_T 1.386 0.99
134_M 144_A 1.382 0.99
32_P 36_H 1.378 0.99
43_A 65_I 1.378 0.99
427_L 479_G 1.375 0.99
115_L 118_E 1.366 0.99
34_A 363_W 1.361 0.99
135_G 140_T 1.36 0.99
205_S 212_G 1.356 0.99
242_P 245_V 1.355 0.99
64_T 319_S 1.351 0.99
171_I 198_M 1.347 0.99
139_L 256_Y 1.344 0.99
120_S 290_L 1.343 0.99
295_L 299_G 1.343 0.99
54_P 58_I 1.339 0.99
47_G 58_I 1.339 0.99
63_V 96_L 1.335 0.98
458_K 461_W 1.323 0.98
204_L 247_L 1.319 0.98
409_I 428_L 1.312 0.98
292_G 296_L 1.295 0.98
113_F 297_S 1.292 0.98
44_M 58_I 1.292 0.98
293_L 317_A 1.287 0.98
21_M 42_V 1.284 0.98
303_F 306_E 1.274 0.98
17_V 20_V 1.266 0.98
247_L 471_Y 1.265 0.98
430_L 436_G 1.256 0.97
358_S 407_P 1.255 0.97
37_Y 66_C 1.249 0.97
296_L 300_L 1.249 0.97
235_Q 422_E 1.247 0.97
355_L 361_I 1.244 0.97
125_R 128_L 1.244 0.97
40_V 44_M 1.242 0.97
296_L 320_L 1.226 0.97
465_A 469_V 1.222 0.97
206_S 212_G 1.216 0.97
47_G 61_I 1.216 0.97
253_W 256_Y 1.213 0.97
438_L 465_A 1.21 0.97
330_K 333_T 1.207 0.97
37_Y 354_G 1.199 0.96
214_A 399_S 1.195 0.96
250_I 470_I 1.192 0.96
109_G 318_V 1.185 0.96
459_D 463_L 1.18 0.96
209_F 212_G 1.176 0.96
391_A 395_F 1.176 0.96
215_P 399_S 1.174 0.96
430_L 435_M 1.167 0.96
36_H 77_A 1.166 0.96
56_T 340_N 1.162 0.96
104_V 342_L 1.158 0.95
160_T 213_A 1.158 0.95
280_M 287_E 1.155 0.95
393_Y 398_L 1.152 0.95
399_S 443_T 1.141 0.95
107_V 399_S 1.141 0.95
411_A 414_K 1.14 0.95
18_M 22_F 1.14 0.95
206_S 209_F 1.139 0.95
106_L 159_N 1.139 0.95
103_T 107_V 1.136 0.95
154_P 208_M 1.135 0.95
366_G 370_T 1.135 0.95
158_S 161_A 1.134 0.95
300_L 316_L 1.132 0.95
367_T 370_T 1.127 0.94
55_A 59_S 1.127 0.94
205_S 209_F 1.124 0.94
60_F 343_V 1.116 0.94
31_P 34_A 1.112 0.94
206_S 213_A 1.11 0.94
125_R 287_E 1.11 0.94
48_M 348_L 1.108 0.94
392_H 401_H 1.107 0.94
204_L 251_A 1.105 0.94
149_D 202_T 1.098 0.93
8_I 12_L 1.097 0.93
159_N 206_S 1.094 0.93
389_Y 405_M 1.092 0.93
9_W 13_A 1.09 0.93
10_K 14_P 1.088 0.93
330_K 335_Y 1.086 0.93
345_L 399_S 1.084 0.93
63_V 347_T 1.082 0.93
254_L 470_I 1.082 0.93
300_L 313_V 1.081 0.93
402_T 432_I 1.081 0.93
284_T 287_E 1.078 0.93
36_H 75_F 1.077 0.93
246_I 474_M 1.072 0.92
419_V 424_L 1.07 0.92
139_L 252_P 1.068 0.92
41_F 355_L 1.066 0.92
347_T 351_M 1.066 0.92
9_W 12_L 1.063 0.92
125_R 129_F 1.062 0.92
321_M 325_H 1.059 0.92
127_A 174_L 1.054 0.91
21_M 39_A 1.051 0.91
48_M 59_S 1.05 0.91
199_V 445_P 1.049 0.91
168_F 448_I 1.049 0.91
42_V 46_V 1.048 0.91
293_L 324_L 1.046 0.91
124_R 128_L 1.043 0.91
20_V 24_I 1.042 0.91
148_I 167_V 1.036 0.90
314_G 317_A 1.033 0.90
162_R 202_T 1.032 0.90
378_N 480_W 1.032 0.90
23_L 26_V 1.03 0.90
414_K 421_M 1.029 0.90
215_P 402_T 1.028 0.90
75_F 80_L 1.019 0.89
399_S 444_G 1.019 0.89
66_C 77_A 1.019 0.89
153_A 206_S 1.015 0.89
67_V 312_A 1.015 0.89
160_T 397_S 1.015 0.89
375_F 379_A 1.014 0.89
153_A 159_N 1.011 0.89
289_T 326_V 1.004 0.89
161_A 236_W 1.002 0.88
115_L 337_S 1.001 0.88
56_T 333_T 1 0.88
254_L 257_V 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.90141000.42Contact Map0.687
2rddB10.07396.20.975Contact Map0.262
2ksfA10.215640.977Contact Map0.108
4j72A20.48873.50.978Contact Map0.409
2nwlA30.48053.10.979Contact Map0.278
3w9iA60.33261.90.981Contact Map0.259
4he8H20.12321.80.981Contact Map0.243
1pi7A10.07391.50.982Contact Map0.767
3aqpA20.33061.30.983Contact Map0.338
2m20A20.11911.20.983Contact Map0.165
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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