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OPENSEQ.org
ZITB - Zinc transporter ZitB
UniProt: P75757 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13662
Length: 313 (275)
Sequences: 4642
Seq/Len: 16.88
ZITB
Paralog alert: 0.75 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FIEF ZITB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
184_P 188_I 3.72 1.00
240_H 258_Q 3.086 1.00
257_V 287_I 3.044 1.00
106_V 191_I 2.733 1.00
229_M 257_V 2.665 1.00
229_M 272_I 2.632 1.00
38_G 127_I 2.547 1.00
199_R 203_R 2.53 1.00
210_N 215_G 2.352 1.00
76_T 83_W 2.332 1.00
86_L 213_L 2.216 1.00
228_R 279_H 2.177 1.00
226_K 231_R 2.155 1.00
228_R 280_Y 2.103 1.00
79_H 83_W 2.075 1.00
266_D 288_Q 2.061 1.00
126_A 130_A 2.017 1.00
95_A 205_L 1.994 1.00
146_S 154_R 1.936 1.00
39_G 48_L 1.935 1.00
36_V 51_A 1.918 1.00
107_W 111_E 1.886 1.00
105_I 190_S 1.875 1.00
237_R 261_P 1.849 1.00
206_K 210_N 1.797 1.00
224_E 279_H 1.78 1.00
223_A 227_R 1.689 1.00
264_D 267_A 1.673 1.00
129_V 133_L 1.667 1.00
85_R 214_E 1.661 1.00
233_I 272_I 1.658 1.00
233_I 275_Y 1.658 1.00
274_H 278_D 1.651 1.00
27_V 134_A 1.634 1.00
125_M 171_I 1.634 1.00
36_V 40_F 1.623 1.00
129_V 171_I 1.622 1.00
195_L 199_R 1.615 1.00
228_R 275_Y 1.588 1.00
53_H 159_H 1.582 1.00
106_V 194_S 1.579 1.00
22_L 26_G 1.535 1.00
62_L 66_L 1.523 1.00
18_A 72_R 1.508 1.00
37_V 41_L 1.499 1.00
143_H 147_E 1.485 1.00
191_I 195_L 1.481 1.00
214_E 254_T 1.475 1.00
154_R 207_D 1.472 1.00
35_E 54_M 1.464 1.00
240_H 290_E 1.445 1.00
169_G 189_L 1.441 1.00
227_R 232_E 1.433 1.00
67_A 90_A 1.396 0.99
22_L 65_L 1.384 0.99
271_Q 275_Y 1.377 0.99
222_I 244_V 1.374 0.99
125_M 174_A 1.367 0.99
76_T 79_H 1.361 0.99
29_A 58_T 1.355 0.99
103_I 107_W 1.335 0.99
50_D 167_S 1.331 0.99
81_F 256_H 1.329 0.99
45_L 109_A 1.328 0.99
175_L 179_W 1.328 0.99
156_A 159_H 1.324 0.99
238_N 259_V 1.323 0.99
176_I 185_A 1.317 0.99
175_L 178_I 1.314 0.99
102_T 198_L 1.31 0.99
255_L 282_I 1.309 0.99
244_V 255_L 1.308 0.99
113_F 184_P 1.304 0.99
233_I 271_Q 1.304 0.99
267_A 271_Q 1.293 0.99
265_H 289_M 1.287 0.99
233_I 268_L 1.284 0.99
136_I 140_W 1.279 0.99
202_W 206_K 1.272 0.99
275_Y 279_H 1.27 0.99
29_A 33_L 1.269 0.99
31_F 134_A 1.265 0.99
79_H 210_N 1.257 0.99
110_I 114_R 1.256 0.99
266_D 291_Y 1.248 0.99
140_W 144_H 1.246 0.98
78_R 83_W 1.245 0.98
109_A 190_S 1.239 0.98
18_A 69_Q 1.235 0.98
64_A 155_A 1.231 0.98
270_D 274_H 1.22 0.98
69_Q 72_R 1.22 0.98
225_L 244_V 1.214 0.98
184_P 187_P 1.205 0.98
243_H 284_H 1.205 0.98
143_H 157_A 1.199 0.98
108_E 111_E 1.199 0.98
31_F 35_E 1.198 0.98
258_Q 290_E 1.195 0.98
88_T 211_E 1.191 0.98
111_E 115_T 1.18 0.98
89_L 213_L 1.167 0.97
176_I 180_T 1.164 0.97
99_V 201_A 1.159 0.97
222_I 226_K 1.157 0.97
263_H 267_A 1.147 0.97
39_G 51_A 1.146 0.97
231_R 238_N 1.14 0.97
25_F 58_T 1.14 0.97
42_S 124_M 1.133 0.97
217_P 244_V 1.126 0.97
80_T 216_A 1.119 0.96
241_H 284_H 1.109 0.96
53_H 57_D 1.107 0.96
50_D 53_H 1.103 0.96
33_L 37_V 1.096 0.96
269_L 289_M 1.087 0.96
133_L 137_L 1.086 0.96
110_I 191_I 1.078 0.95
224_E 227_R 1.068 0.95
214_E 247_V 1.064 0.95
270_D 273_Q 1.055 0.95
223_A 226_K 1.054 0.95
225_L 276_L 1.052 0.95
269_L 288_Q 1.051 0.94
32_M 36_V 1.049 0.94
242_V 257_V 1.049 0.94
109_A 191_I 1.044 0.94
113_F 191_I 1.044 0.94
221_D 224_E 1.043 0.94
168_V 172_I 1.042 0.94
24_A 138_S 1.032 0.94
104_L 107_W 1.03 0.94
135_N 160_V 1.029 0.94
214_E 245_W 1.028 0.94
159_H 162_G 1.026 0.94
39_G 42_S 1.026 0.94
70_F 86_L 1.024 0.93
137_L 140_W 1.023 0.93
273_Q 288_Q 1.023 0.93
99_V 202_W 1.021 0.93
173_A 189_L 1.02 0.93
188_I 192_L 1.014 0.93
42_S 123_M 1.012 0.93
26_G 30_G 1.009 0.93
63_F 90_A 1.007 0.93
260_I 265_H 1.007 0.93
19_R 23_Y 1.002 0.92
23_Y 141_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3j1zP20.94891000.181Contact Map0.586
3h90A40.87861000.226Contact Map0.635
2zztA10.313199.60.779Contact Map0.553
3bypA20.27899.50.795Contact Map0.694
2oarA50.47670.40.944Contact Map0.349
3rlbA20.463346.80.951Contact Map0.28
4m1aA20.332345.50.952Contact Map0.443
3hzqA10.329142.70.952Contact Map0.357
2jsxA10.2971370.954Contact Map0.303
4dveA30.559133.70.955Contact Map0.299
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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