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RIR2 - Ribonucleoside-diphosphate reductase 1 subunit beta
UniProt: P69924 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10661
Length: 376 (338)
Sequences: 1137
Seq/Len: 3.36
RIR2
Paralog alert: 0.27 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: RIR2 RIR4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
149_K 286_D 5.56 1.00
289_D 306_C 3.497 1.00
68_E 71_K 3.471 1.00
270_K 323_D 3.34 1.00
54_V 122_S 3.293 1.00
271_Q 275_D 2.769 1.00
148_Q 152_E 2.723 1.00
278_V 325_P 2.575 1.00
285_K 310_E 2.553 1.00
274_Y 323_D 2.514 1.00
274_Y 325_P 2.341 1.00
267_E 271_Q 2.335 1.00
198_L 249_M 2.315 1.00
274_Y 278_V 2.295 1.00
314_N 327_Q 2.2 1.00
56_V 125_H 2.152 1.00
85_D 123_Y 2.014 1.00
196_L 272_E 2.002 1.00
72_H 76_S 1.93 1.00
281_A 313_T 1.907 1.00
274_Y 317_M 1.894 1.00
88_Q 158_Y 1.868 0.99
285_K 306_C 1.822 0.99
205_E 239_E 1.798 0.99
149_K 279_Q 1.76 0.99
199_M 273_C 1.757 0.99
272_E 275_D 1.737 0.99
116_E 205_E 1.729 0.99
275_D 279_Q 1.722 0.99
152_E 156_S 1.712 0.99
243_L 315_I 1.71 0.99
145_E 149_K 1.708 0.99
275_D 278_V 1.688 0.99
209_F 239_E 1.643 0.98
29_Y 107_T 1.586 0.98
75_I 131_V 1.573 0.98
199_M 320_V 1.572 0.98
250_L 260_P 1.57 0.98
110_E 113_A 1.565 0.97
278_V 282_Q 1.55 0.97
63_Y 75_I 1.547 0.97
44_Q 115_S 1.5 0.97
126_I 228_N 1.498 0.96
203_A 277_F 1.492 0.96
274_Y 322_L 1.489 0.96
73_I 297_M 1.473 0.96
318_Q 324_L 1.469 0.96
307_Q 329_R 1.468 0.96
24_V 355_S 1.456 0.96
347_V 352_V 1.453 0.96
310_E 329_R 1.451 0.96
209_F 235_I 1.447 0.95
89_G 117_T 1.443 0.95
296_S 303_D 1.437 0.95
333_I 336_I 1.429 0.95
116_E 239_E 1.411 0.95
250_L 322_L 1.41 0.95
254_R 270_K 1.401 0.94
281_A 326_F 1.362 0.93
324_L 327_Q 1.357 0.93
278_V 326_F 1.355 0.93
279_Q 282_Q 1.343 0.93
156_S 279_Q 1.332 0.92
369_D 372_S 1.321 0.92
67_P 70_E 1.314 0.91
270_K 274_Y 1.313 0.91
297_M 307_Q 1.312 0.91
368_T 371_L 1.309 0.91
62_D 65_A 1.285 0.90
85_D 228_N 1.278 0.90
35_D 39_K 1.263 0.89
110_E 117_T 1.248 0.88
277_F 317_M 1.245 0.88
94_V 97_L 1.242 0.88
76_S 143_T 1.241 0.88
289_D 302_K 1.23 0.87
139_D 143_T 1.22 0.87
184_T 188_R 1.217 0.87
45_L 50_R 1.208 0.86
192_K 272_E 1.207 0.86
199_M 269_C 1.206 0.86
119_H 242_H 1.203 0.86
34_Y 102_I 1.192 0.85
108_W 245_G 1.188 0.85
69_H 296_S 1.183 0.84
214_A 288_A 1.178 0.84
282_Q 286_D 1.172 0.84
100_I 109_V 1.172 0.84
242_H 357_Y 1.164 0.83
71_K 307_Q 1.163 0.83
318_Q 323_D 1.158 0.83
267_E 270_K 1.157 0.83
267_E 286_D 1.156 0.83
239_E 242_H 1.155 0.83
111_T 115_S 1.146 0.82
261_E 275_D 1.144 0.82
213_F 239_E 1.125 0.80
156_S 270_K 1.124 0.80
247_Q 319_A 1.12 0.80
145_E 303_D 1.113 0.79
100_I 194_L 1.113 0.79
66_L 71_K 1.098 0.78
205_E 209_F 1.096 0.78
205_E 213_F 1.095 0.78
64_Q 132_N 1.095 0.78
60_R 64_Q 1.094 0.78
73_I 291_L 1.088 0.77
351_E 354_V 1.087 0.77
275_D 282_Q 1.085 0.77
51_P 125_H 1.084 0.77
66_L 225_M 1.084 0.77
306_C 310_E 1.081 0.76
44_Q 112_W 1.078 0.76
116_E 209_F 1.07 0.75
51_P 122_S 1.069 0.75
258_D 262_M 1.064 0.75
160_E 192_K 1.058 0.74
71_K 323_D 1.054 0.74
244_T 311_Y 1.053 0.74
271_Q 274_Y 1.049 0.73
69_H 72_H 1.049 0.73
74_F 228_N 1.049 0.73
358_L 363_D 1.048 0.73
93_N 97_L 1.048 0.73
42_E 46_S 1.047 0.73
350_Q 357_Y 1.045 0.73
189_E 193_K 1.041 0.72
44_Q 241_L 1.036 0.72
217_F 236_A 1.035 0.72
73_I 215_C 1.033 0.72
119_H 239_E 1.032 0.72
36_I 252_L 1.032 0.72
273_C 322_L 1.031 0.71
349_P 357_Y 1.026 0.71
40_L 106_E 1.025 0.71
68_E 282_Q 1.024 0.71
184_T 187_L 1.022 0.70
16_E 19_F 1.021 0.70
63_Y 130_I 1.02 0.70
25_N 139_D 1.016 0.70
21_G 102_I 1.008 0.69
23_P 103_P 1.007 0.69
304_I 307_Q 1.005 0.69
261_E 268_E 1.005 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mxrA20.99731000.095Contact Map0.637
2rccA30.89891000.172Contact Map0.642
1syyA10.90691000.205Contact Map0.556
1h0oA10.8751000.242Contact Map0.679
1jk0B10.87771000.243Contact Map0.61
1jk0A10.88031000.243Contact Map0.681
2p1iA80.87231000.25Contact Map0.766
3n37A10.83241000.257Contact Map0.502
4a58A20.83241000.26Contact Map0.584
3dhzA20.8591000.263Contact Map0.685
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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