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RIR4 - Ribonucleoside-diphosphate reductase 2 subunit beta
UniProt: P37146 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12381
Length: 319 (312)
Sequences: 1183
Seq/Len: 3.79
RIR4
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RIR2 RIR4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
133_R 235_Q 5.013 1.00
36_V 104_S 3.462 1.00
50_V 53_Q 3.288 1.00
238_D 251_K 3.286 1.00
283_L 286_L 3.238 1.00
132_Q 136_Q 2.706 1.00
227_L 270_L 2.522 1.00
234_L 255_C 2.454 1.00
220_S 224_D 2.338 1.00
216_E 220_S 2.334 1.00
223_F 270_L 2.321 1.00
223_F 268_E 2.262 1.00
223_F 227_L 2.244 1.00
259_N 272_P 2.209 1.00
151_K 202_K 2.167 1.00
149_K 221_F 2.156 1.00
219_K 268_E 2.122 1.00
234_L 251_K 1.966 1.00
38_L 107_S 1.934 1.00
54_Q 58_R 1.896 1.00
156_F 226_L 1.867 1.00
196_G 260_K 1.841 1.00
152_I 222_A 1.836 1.00
230_Y 258_A 1.808 0.99
57_M 117_D 1.787 0.99
79_M 82_A 1.772 0.99
221_F 224_D 1.768 0.99
136_Q 140_Q 1.761 0.99
10_N 13_K 1.759 0.99
129_A 133_R 1.747 0.99
67_D 105_Y 1.741 0.99
203_Y 210_I 1.737 0.99
294_H 299_G 1.734 0.99
70_Q 142_Y 1.732 0.99
223_F 262_L 1.683 0.99
283_L 287_S 1.665 0.99
92_S 95_S 1.643 0.99
210_I 214_Q 1.633 0.99
227_L 271_F 1.616 0.99
227_L 231_D 1.613 0.98
224_D 227_L 1.607 0.98
224_D 228_E 1.597 0.98
216_E 219_K 1.595 0.98
158_E 192_E 1.586 0.98
152_I 265_L 1.579 0.98
78_L 82_A 1.545 0.98
255_C 273_A 1.532 0.98
108_I 181_T 1.497 0.97
224_D 231_D 1.479 0.97
205_K 209_K 1.478 0.97
223_F 267_Y 1.449 0.96
26_L 97_M 1.437 0.96
79_M 83_L 1.435 0.96
205_K 208_E 1.418 0.96
269_P 272_P 1.403 0.96
162_F 192_E 1.403 0.96
98_E 158_E 1.398 0.95
53_Q 117_D 1.382 0.95
78_L 83_L 1.361 0.94
203_Y 267_Y 1.354 0.94
263_M 269_P 1.331 0.94
45_W 57_M 1.326 0.93
162_F 188_I 1.316 0.93
79_M 84_T 1.316 0.93
49_T 52_E 1.315 0.93
78_L 84_T 1.3 0.93
71_N 99_A 1.299 0.92
133_R 228_E 1.299 0.92
298_S 301_G 1.291 0.92
282_I 285_A 1.281 0.92
57_M 113_C 1.278 0.92
27_T 32_L 1.272 0.91
78_L 81_D 1.266 0.91
138_I 157_L 1.258 0.91
167_W 237_T 1.24 0.90
93_N 97_M 1.228 0.89
44_A 47_T 1.225 0.89
230_Y 271_F 1.219 0.89
51_V 243_E 1.197 0.88
273_A 278_V 1.196 0.88
212_L 268_E 1.189 0.87
211_S 214_Q 1.188 0.87
98_E 162_F 1.167 0.86
46_Q 120_A 1.165 0.86
67_D 181_T 1.163 0.86
92_S 99_A 1.161 0.86
140_Q 228_E 1.156 0.85
90_V 198_Y 1.152 0.85
195_H 304_Y 1.147 0.85
296_F 304_Y 1.146 0.85
297_F 304_Y 1.146 0.85
192_E 195_H 1.145 0.84
83_L 91_L 1.138 0.84
33_P 36_V 1.134 0.84
98_E 192_E 1.133 0.84
33_P 104_S 1.129 0.83
117_D 120_A 1.12 0.83
252_A 277_E 1.12 0.83
42_I 46_Q 1.119 0.83
48_L 53_Q 1.119 0.83
123_A 127_E 1.108 0.82
287_S 290_A 1.106 0.82
228_E 231_D 1.101 0.81
222_A 267_Y 1.098 0.81
58_R 127_E 1.095 0.81
226_L 262_L 1.091 0.80
295_D 298_S 1.083 0.80
251_K 255_C 1.079 0.79
160_F 226_L 1.073 0.79
101_H 195_H 1.072 0.79
216_E 235_Q 1.072 0.79
152_I 218_L 1.071 0.79
252_A 273_A 1.071 0.79
51_V 54_Q 1.069 0.78
27_T 33_P 1.068 0.78
263_M 268_E 1.068 0.78
24_N 103_R 1.066 0.78
285_A 288_P 1.065 0.78
45_W 112_L 1.055 0.77
26_L 94_I 1.053 0.77
286_L 289_N 1.052 0.77
206_N 210_I 1.051 0.77
147_P 151_K 1.05 0.77
272_P 278_V 1.05 0.77
56_T 181_T 1.043 0.76
113_C 286_L 1.042 0.76
158_E 166_F 1.031 0.75
205_K 212_L 1.026 0.74
16_D 19_D 1.021 0.74
83_L 147_P 1.019 0.74
59_V 165_G 1.016 0.73
71_N 95_S 1.01 0.73
30_F 34_E 1.006 0.72
256_Y 260_K 1.004 0.72
173_S 182_A 1.003 0.72
47_T 248_D 1.002 0.72
53_Q 252_A 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3n37A10.99061000.086Contact Map0.516
4dr0A20.98751000.097Contact Map0.651
3dhzA20.99061000.104Contact Map0.709
1mxrA20.97491000.13Contact Map0.624
2rccA30.96871000.138Contact Map0.659
1jk0A10.95611000.158Contact Map0.697
1h0oA10.95611000.158Contact Map0.707
1syyA10.94981000.16Contact Map0.583
1jk0B10.94671000.166Contact Map0.616
2p1iA80.95611000.174Contact Map0.78
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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