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OPENSEQ.org

PTND - Mannose permease IID component
UniProt: P69805 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10569
Length: 283 (272)
Sequences: 709
Seq/Len: 2.61

PTND
Paralog alert: 0.74 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: PTND PTPD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
233_T 236_D 3.965 1.00
74_T 116_A 3.78 1.00
56_E 60_A 3.179 1.00
50_I 61_R 3.117 1.00
260_N 263_W 3.045 1.00
266_V 270_V 2.858 1.00
17_D 52_R 2.72 1.00
14_T 17_D 2.646 1.00
58_N 62_K 2.636 1.00
148_L 152_I 2.416 1.00
46_M 50_I 2.241 1.00
49_A 87_L 2.202 1.00
135_G 146_G 2.199 1.00
230_T 233_T 2.061 1.00
250_A 253_W 2.048 1.00
246_L 250_A 2.004 0.99
149_L 153_L 1.985 0.99
16_S 20_G 1.977 0.99
275_G 281_L 1.877 0.99
232_Q 236_D 1.867 0.99
271_I 275_G 1.862 0.99
132_A 150_F 1.779 0.98
13_L 49_A 1.762 0.98
29_Q 32_W 1.761 0.98
82_I 116_A 1.76 0.98
13_L 17_D 1.745 0.98
72_F 79_A 1.691 0.98
42_F 86_T 1.689 0.98
68_H 108_K 1.675 0.97
152_I 156_L 1.625 0.97
72_F 82_I 1.622 0.97
128_R 150_F 1.622 0.97
91_E 170_Y 1.619 0.97
63_Q 101_D 1.607 0.97
212_I 243_V 1.552 0.96
175_D 178_K 1.542 0.95
251_C 268_F 1.532 0.95
15_Q 167_A 1.513 0.95
18_I 167_A 1.512 0.95
56_E 59_E 1.491 0.94
18_I 166_V 1.489 0.94
74_T 82_I 1.474 0.94
212_I 231_V 1.466 0.93
24_R 44_F 1.46 0.93
259_V 267_G 1.446 0.93
43_C 65_I 1.425 0.92
264_I 268_F 1.424 0.92
58_N 61_R 1.407 0.91
274_A 278_C 1.403 0.91
25_S 79_A 1.401 0.91
275_G 280_L 1.396 0.91
55_P 58_N 1.387 0.91
13_L 87_L 1.354 0.89
105_N 109_V 1.336 0.88
247_L 268_F 1.316 0.87
68_H 90_E 1.31 0.87
93_R 101_D 1.301 0.87
56_E 62_K 1.288 0.86
211_N 236_D 1.287 0.86
28_F 38_Q 1.273 0.85
38_Q 116_A 1.271 0.85
21_V 49_A 1.26 0.84
210_V 247_L 1.244 0.83
70_E 105_N 1.242 0.83
33_N 272_G 1.232 0.82
214_L 231_V 1.231 0.82
13_L 18_I 1.228 0.82
67_R 108_K 1.209 0.81
213_P 281_L 1.207 0.80
190_E 194_I 1.2 0.80
38_Q 74_T 1.195 0.80
131_F 157_V 1.19 0.79
59_E 62_K 1.188 0.79
224_G 228_V 1.184 0.79
145_L 148_L 1.173 0.78
72_F 83_L 1.172 0.78
56_E 61_R 1.167 0.77
43_C 46_M 1.165 0.77
210_V 243_V 1.165 0.77
131_F 153_L 1.158 0.76
53_L 95_N 1.142 0.75
163_Y 167_A 1.135 0.74
211_N 275_G 1.129 0.74
278_C 281_L 1.122 0.73
250_A 271_I 1.121 0.73
64_A 67_R 1.12 0.73
168_Y 171_S 1.118 0.73
21_V 166_V 1.115 0.73
36_R 39_A 1.113 0.72
118_V 159_L 1.113 0.72
232_Q 235_L 1.111 0.72
144_L 147_P 1.111 0.72
93_R 96_G 1.097 0.71
32_W 39_A 1.09 0.70
28_F 79_A 1.088 0.70
45_S 83_L 1.083 0.69
204_V 248_T 1.081 0.69
220_T 228_V 1.081 0.69
55_P 60_A 1.079 0.69
267_G 271_I 1.078 0.69
251_C 264_I 1.076 0.69
96_G 99_I 1.069 0.68
273_I 277_A 1.067 0.68
156_L 160_A 1.063 0.67
191_G 264_I 1.058 0.67
89_L 103_A 1.052 0.66
88_A 192_A 1.05 0.66
210_V 281_L 1.049 0.66
213_P 282_G 1.049 0.66
208_T 211_N 1.042 0.65
49_A 53_L 1.041 0.65
62_K 66_R 1.036 0.64
103_A 107_I 1.035 0.64
129_P 203_L 1.03 0.64
244_P 248_T 1.028 0.64
22_F 162_R 1.028 0.64
209_H 241_G 1.028 0.64
22_F 163_Y 1.026 0.63
51_R 61_R 1.025 0.63
29_Q 37_M 1.025 0.63
37_M 123_F 1.014 0.62
263_W 267_G 1.014 0.62
33_N 36_R 1.011 0.62
53_L 91_E 1.01 0.62
134_L 149_L 1.006 0.61
245_L 249_F 1.005 0.61
259_V 263_W 1.003 0.61
218_R 221_D 1.003 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
4b19A10.10257.90.976Contact Map0.497
2jttC20.123760.977Contact Map0.26
3pf6A40.19795.10.978Contact Map0.09
2laiA10.26153.60.98Contact Map0.15
2rrfA10.19433.20.98Contact Map0.283
4hygA40.3182.90.981Contact Map0.443
3owqA40.25442.60.981Contact Map0.515
1t0fC20.18372.50.981Contact Map0.363
2l8sA10.10252.50.981Contact Map0.3
1oahA20.32862.50.981Contact Map0.193

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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