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YAER - Uncharacterized protein YaeR
UniProt: P52096 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13224
Length: 129 (128)
Sequences: 4545
Seq/Len: 35.51

YAER
Paralog alert: 0.72 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: LGUL YAER
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_A 26_D 5.664 1.00
91_A 95_S 3.581 1.00
92_H 96_H 3.392 1.00
85_D 88_A 2.993 1.00
16_D 19_V 2.834 1.00
90_V 114_T 2.487 1.00
87_D 112_R 2.41 1.00
26_D 96_H 2.356 1.00
20_S 120_D 2.275 1.00
99_K 117_N 1.991 1.00
90_V 94_E 1.975 1.00
14_A 20_S 1.973 1.00
31_T 49_A 1.899 1.00
27_I 96_H 1.897 1.00
91_A 94_E 1.896 1.00
21_K 25_C 1.833 1.00
78_H 125_E 1.811 1.00
9_H 78_H 1.763 1.00
24_Y 118_D 1.743 1.00
6_Q 82_S 1.742 1.00
89_A 92_H 1.73 1.00
93_L 98_V 1.71 1.00
19_V 120_D 1.709 1.00
33_Q 49_A 1.662 1.00
82_S 129_Q 1.649 1.00
118_D 122_L 1.644 1.00
18_A 22_A 1.577 1.00
5_K 84_D 1.563 1.00
112_R 128_E 1.5 1.00
32_L 35_E 1.485 1.00
15_T 120_D 1.452 1.00
9_H 80_A 1.449 1.00
19_V 22_A 1.424 1.00
87_D 91_A 1.416 1.00
6_Q 53_Q 1.382 0.99
116_F 124_L 1.37 0.99
9_H 125_E 1.357 0.99
114_T 126_L 1.341 0.99
117_N 123_P 1.293 0.99
21_K 35_E 1.287 0.99
98_V 116_F 1.281 0.99
93_L 126_L 1.256 0.99
25_C 31_T 1.255 0.99
90_V 100_C 1.241 0.98
116_F 126_L 1.228 0.98
83_V 89_A 1.227 0.98
21_K 32_L 1.194 0.98
8_H 82_S 1.194 0.98
23_F 119_P 1.188 0.98
94_E 100_C 1.179 0.98
88_A 91_A 1.145 0.97
25_C 32_L 1.134 0.97
88_A 92_H 1.126 0.97
18_A 35_E 1.099 0.96
85_D 128_E 1.074 0.95
22_A 25_C 1.073 0.95
101_E 117_N 1.072 0.95
92_H 95_S 1.05 0.94
15_T 19_V 1.046 0.94
30_F 50_L 1.034 0.94
115_F 125_E 1.033 0.94
42_D 63_F 1.028 0.94
14_A 58_L 1.024 0.93
22_A 27_I 1.019 0.93
32_L 46_G 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2p25A10.976799.90.193Contact Map0.7
3l7tA40.96999.90.211Contact Map0.822
3hdpA10.976799.80.23Contact Map0.555
1ss4A20.984599.80.233Contact Map0.814
2c21A60.945799.80.234Contact Map0.834
3kolA10.984599.80.24Contact Map0.668
2rk0A20.961299.80.249Contact Map0.687
1jc4A40.992299.80.252Contact Map0.773
1f9zA20.945799.80.253Contact Map0.895
3gm5A10.976799.80.257Contact Map0.643

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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