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LGUL - Lactoylglutathione lyase
UniProt: P0AC81 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13421
Length: 135 (128)
Sequences: 4300
Seq/Len: 33.59

LGUL
Paralog alert: 0.68 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: LGUL YAER
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_D 22_K 5.551 1.00
87_E 91_Q 3.559 1.00
88_K 92_N 3.386 1.00
81_N 84_E 3.012 1.00
12_D 15_R 2.749 1.00
86_C 111_A 2.327 1.00
16_S 117_D 2.232 1.00
83_A 109_V 2.231 1.00
22_K 92_N 2.203 1.00
10_V 16_S 2.125 1.00
95_N 114_E 2.036 1.00
20_Y 115_D 1.948 1.00
90_R 99_E 1.925 1.00
86_C 90_R 1.813 1.00
87_E 90_R 1.801 1.00
23_V 92_N 1.703 1.00
89_I 94_G 1.658 1.00
2_R 78_S 1.634 1.00
78_S 126_E 1.633 1.00
14_Q 18_D 1.612 1.00
85_A 88_K 1.598 1.00
28_L 31_T 1.578 1.00
5_H 74_H 1.574 1.00
15_R 117_D 1.503 1.00
29_L 45_G 1.496 1.00
17_I 21_T 1.487 1.00
74_H 122_E 1.459 1.00
83_A 87_E 1.457 1.00
27_K 45_G 1.45 1.00
2_R 52_E 1.415 1.00
31_T 40_S 1.401 0.99
115_D 119_Y 1.363 0.99
114_E 120_K 1.358 0.99
109_V 125_E 1.341 0.99
86_C 96_V 1.338 0.99
4_L 78_S 1.324 0.99
79_V 85_A 1.303 0.99
40_S 59_Y 1.289 0.99
11_G 117_D 1.261 0.99
89_I 123_L 1.261 0.99
13_L 42_A 1.255 0.99
17_I 42_A 1.255 0.99
17_I 31_T 1.25 0.99
14_Q 31_T 1.238 0.98
90_R 96_V 1.223 0.98
47_G 52_E 1.223 0.98
17_I 28_L 1.202 0.98
84_E 87_E 1.186 0.98
15_R 18_D 1.185 0.98
5_H 76_A 1.175 0.98
38_K 62_G 1.161 0.97
28_L 42_A 1.14 0.97
17_I 44_V 1.128 0.97
94_G 113_V 1.1 0.96
18_D 21_T 1.1 0.96
26_M 46_Y 1.1 0.96
113_V 121_I 1.097 0.96
21_T 28_L 1.094 0.96
21_T 27_K 1.071 0.95
33_E 40_S 1.071 0.95
19_F 116_P 1.058 0.95
113_V 123_L 1.056 0.95
112_F 122_E 1.041 0.94
11_G 15_R 1.04 0.94
16_S 57_L 1.019 0.93
111_A 123_L 1.008 0.93
18_D 23_V 1.006 0.93
43_F 56_E 1.005 0.93
5_H 122_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1f9zA2199.90.254Contact Map0.884
3hdpA10.896399.90.289Contact Map0.559
1ss4A20.933399.90.29Contact Map0.809
2c21A60.96399.80.308Contact Map0.85
3rmuA40.903799.80.311Contact Map0.707
3gm5A10.888999.80.315Contact Map0.635
3e5dA10.896399.80.316Contact Map0.739
1jc4A40.948199.80.316Contact Map0.791
2p25A10.888999.80.319Contact Map0.713
3w0tA40.970499.80.323Contact Map0.863

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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