| UniProt: | P50465 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13237 | ||
| Length: | 263 (261) | ||
| Sequences: | 2234 | ||
| Seq/Len: | 8.56 |
| END8
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs Cluster includes: END8 FPG |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 185_H | 194_Q | 3.877 | 1.00 | |
| 49_E | 58_H | 3.533 | 1.00 | |
| 245_I | 256_Y | 3.337 | 1.00 | |
| 154_F | 181_L | 3.169 | 1.00 | |
| 167_L | 172_R | 2.876 | 1.00 | |
| 21_K | 98_D | 2.851 | 1.00 | |
| 191_N | 194_Q | 2.724 | 1.00 | |
| 137_P | 199_A | 2.568 | 1.00 | |
| 178_Q | 208_F | 2.493 | 1.00 | |
| 56_L | 64_T | 2.47 | 1.00 | |
| 15_E | 19_K | 2.386 | 1.00 | |
| 215_Q | 228_F | 2.295 | 1.00 | |
| 144_L | 157_L | 2.217 | 1.00 | |
| 151_N | 188_K | 2.21 | 1.00 | |
| 190_L | 194_Q | 2.15 | 1.00 | |
| 157_L | 187_A | 2.099 | 1.00 | |
| 243_S | 259_P | 2.075 | 1.00 | |
| 43_Q | 61_N | 2.068 | 1.00 | |
| 229_K | 239_E | 2.05 | 1.00 | |
| 11_A | 55_L | 1.951 | 1.00 | |
| 233_R | 239_E | 1.91 | 1.00 | |
| 27_W | 95_Q | 1.892 | 1.00 | |
| 157_L | 163_F | 1.876 | 1.00 | |
| 25_D | 95_Q | 1.87 | 1.00 | |
| 185_H | 189_D | 1.866 | 1.00 | |
| 21_K | 97_A | 1.845 | 1.00 | |
| 198_L | 202_L | 1.843 | 1.00 | |
| 152_R | 160_D | 1.807 | 1.00 | |
| 194_Q | 197_A | 1.789 | 1.00 | |
| 22_P | 97_A | 1.785 | 1.00 | |
| 92_V | 109_I | 1.743 | 1.00 | |
| 248_T | 257_W | 1.739 | 1.00 | |
| 23_L | 59_F | 1.732 | 1.00 | |
| 43_Q | 60_S | 1.713 | 1.00 | |
| 247_K | 254_P | 1.667 | 1.00 | |
| 137_P | 140_V | 1.66 | 1.00 | |
| 125_R | 162_A | 1.652 | 1.00 | |
| 178_Q | 201_A | 1.642 | 1.00 | |
| 177_W | 240_R | 1.635 | 1.00 | |
| 25_D | 41_I | 1.635 | 1.00 | |
| 233_R | 236_E | 1.628 | 1.00 | |
| 11_A | 15_E | 1.622 | 1.00 | |
| 67_S | 75_W | 1.615 | 1.00 | |
| 152_R | 157_L | 1.611 | 1.00 | |
| 141_K | 192_A | 1.611 | 1.00 | |
| 137_P | 196_D | 1.601 | 1.00 | |
| 258_C | 261_C | 1.575 | 1.00 | |
| 140_V | 199_A | 1.559 | 1.00 | |
| 184_N | 248_T | 1.555 | 1.00 | |
| 67_S | 109_I | 1.54 | 1.00 | |
| 144_L | 154_F | 1.52 | 1.00 | |
| 28_F | 92_V | 1.489 | 1.00 | |
| 181_L | 198_L | 1.482 | 1.00 | |
| 167_L | 202_L | 1.471 | 1.00 | |
| 238_C | 258_C | 1.468 | 1.00 | |
| 139_V | 143_R | 1.466 | 0.99 | |
| 138_E | 192_A | 1.457 | 0.99 | |
| 246_E | 259_P | 1.451 | 0.99 | |
| 167_L | 175_I | 1.446 | 0.99 | |
| 178_Q | 229_K | 1.429 | 0.99 | |
| 8_R | 50_T | 1.425 | 0.99 | |
| 173_V | 256_Y | 1.424 | 0.99 | |
| 179_V | 201_A | 1.422 | 0.99 | |
| 230_V | 245_I | 1.422 | 0.99 | |
| 46_T | 60_S | 1.409 | 0.99 | |
| 178_Q | 205_I | 1.408 | 0.99 | |
| 15_E | 47_H | 1.4 | 0.99 | |
| 144_L | 195_L | 1.391 | 0.99 | |
| 186_K | 189_D | 1.39 | 0.99 | |
| 234_D | 256_Y | 1.382 | 0.99 | |
| 24_T | 97_A | 1.377 | 0.99 | |
| 153_Q | 156_G | 1.375 | 0.99 | |
| 238_C | 241_C | 1.366 | 0.99 | |
| 113_T | 116_Q | 1.363 | 0.99 | |
| 146_S | 188_K | 1.362 | 0.99 | |
| 192_A | 196_D | 1.362 | 0.99 | |
| 136_T | 139_V | 1.354 | 0.99 | |
| 107_S | 220_K | 1.335 | 0.99 | |
| 8_R | 11_A | 1.326 | 0.99 | |
| 139_V | 142_E | 1.303 | 0.99 | |
| 201_A | 204_E | 1.294 | 0.98 | |
| 90_L | 105_S | 1.285 | 0.98 | |
| 59_F | 65_L | 1.284 | 0.98 | |
| 238_C | 261_C | 1.268 | 0.98 | |
| 141_K | 195_L | 1.267 | 0.98 | |
| 135_L | 164_L | 1.267 | 0.98 | |
| 26_V | 40_L | 1.264 | 0.98 | |
| 128_P | 132_D | 1.26 | 0.98 | |
| 182_T | 257_W | 1.256 | 0.98 | |
| 21_K | 100_T | 1.251 | 0.98 | |
| 51_R | 129_D | 1.251 | 0.98 | |
| 8_R | 12_D | 1.251 | 0.98 | |
| 237_P | 243_S | 1.233 | 0.98 | |
| 58_H | 64_T | 1.22 | 0.97 | |
| 178_Q | 204_E | 1.213 | 0.97 | |
| 18_I | 45_V | 1.201 | 0.97 | |
| 241_C | 258_C | 1.188 | 0.97 | |
| 130_V | 135_L | 1.18 | 0.97 | |
| 108_D | 112_L | 1.178 | 0.97 | |
| 48_V | 57_T | 1.174 | 0.97 | |
| 175_I | 202_L | 1.161 | 0.96 | |
| 64_T | 114_P | 1.159 | 0.96 | |
| 45_V | 57_T | 1.15 | 0.96 | |
| 164_L | 167_L | 1.146 | 0.96 | |
| 22_P | 44_H | 1.145 | 0.96 | |
| 132_D | 135_L | 1.127 | 0.95 | |
| 212_T | 227_R | 1.123 | 0.95 | |
| 29_A | 93_K | 1.123 | 0.95 | |
| 44_H | 60_S | 1.108 | 0.95 | |
| 237_P | 244_I | 1.101 | 0.95 | |
| 128_P | 164_L | 1.1 | 0.95 | |
| 18_I | 96_T | 1.099 | 0.95 | |
| 156_G | 251_S | 1.095 | 0.94 | |
| 45_V | 59_F | 1.087 | 0.94 | |
| 23_L | 94_L | 1.083 | 0.94 | |
| 138_E | 142_E | 1.081 | 0.94 | |
| 250_L | 255_F | 1.08 | 0.94 | |
| 182_T | 263_H | 1.079 | 0.94 | |
| 180_G | 240_R | 1.068 | 0.93 | |
| 155_A | 172_R | 1.066 | 0.93 | |
| 241_C | 261_C | 1.055 | 0.93 | |
| 57_T | 67_S | 1.047 | 0.93 | |
| 47_H | 58_H | 1.037 | 0.92 | |
| 93_K | 101_I | 1.031 | 0.92 | |
| 208_F | 227_R | 1.024 | 0.91 | |
| 52_G | 161_Q | 1.013 | 0.91 | |
| 67_S | 104_Y | 1.012 | 0.91 | |
| 246_E | 257_W | 1.011 | 0.91 | |
| 234_D | 247_K | 1.002 | 0.90 | |
| 258_C | 262_Q | 1.001 | 0.90 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1k3xA | 1 | 0.9962 | 100 | 0.05 | Contact Map | 0.747 |
| 2xzfA | 1 | 0.9696 | 100 | 0.068 | Contact Map | 0.827 |
| 3u6pA | 1 | 0.9734 | 100 | 0.069 | Contact Map | 0.881 |
| 1k82A | 4 | 0.962 | 100 | 0.077 | Contact Map | 0.871 |
| 3twlA | 1 | 0.962 | 100 | 0.096 | Contact Map | 0.708 |
| 1ee8A | 2 | 0.9544 | 100 | 0.131 | Contact Map | 0.899 |
| 3vk8A | 2 | 0.9202 | 100 | 0.149 | Contact Map | 0.759 |
| 4mb7A | 1 | 0.9392 | 100 | 0.154 | Contact Map | 0.75 |
| 3w0fA | 1 | 0.9468 | 100 | 0.225 | Contact Map | 0.709 |
| 1tdhA | 1 | 0.9278 | 100 | 0.262 | Contact Map | 0.522 |
Sequence Conservation (Image Generated using WebLogo v3)