| UniProt: | P46852 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12943 | ||
| Length: | 231 (229) | ||
| Sequences: | 2527 | ||
| Seq/Len: | 11.03 |
| YHHW
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs Cluster includes: YHAK YHHW |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 174_V | 214_S | 3.333 | 1.00 | |
| 172_Q | 216_H | 2.943 | 1.00 | |
| 76_Q | 82_K | 2.905 | 1.00 | |
| 193_T | 216_H | 2.735 | 1.00 | |
| 72_T | 86_P | 2.573 | 1.00 | |
| 14_N | 19_D | 2.513 | 1.00 | |
| 172_Q | 214_S | 2.382 | 1.00 | |
| 192_V | 221_S | 2.365 | 1.00 | |
| 191_N | 219_S | 2.336 | 1.00 | |
| 189_K | 222_E | 2.291 | 1.00 | |
| 66_T | 114_L | 2.286 | 1.00 | |
| 74_E | 82_K | 2.257 | 1.00 | |
| 89_E | 134_R | 2.201 | 1.00 | |
| 12_H | 19_D | 2.195 | 1.00 | |
| 48_I | 114_L | 2.168 | 1.00 | |
| 165_W | 223_V | 2.122 | 1.00 | |
| 97_T | 127_T | 2.104 | 1.00 | |
| 115_Y | 188_V | 2.079 | 1.00 | |
| 193_T | 198_K | 2.075 | 1.00 | |
| 164_R | 222_E | 2.035 | 1.00 | |
| 199_A | 205_L | 2.008 | 1.00 | |
| 74_E | 84_Q | 1.985 | 1.00 | |
| 12_H | 21_W | 1.913 | 1.00 | |
| 61_D | 125_G | 1.877 | 1.00 | |
| 115_Y | 224_L | 1.85 | 1.00 | |
| 70_E | 113_H | 1.833 | 1.00 | |
| 15_H | 27_A | 1.797 | 1.00 | |
| 168_L | 220_D | 1.773 | 1.00 | |
| 193_T | 196_G | 1.771 | 1.00 | |
| 177_I | 183_V | 1.763 | 1.00 | |
| 174_V | 212_A | 1.758 | 1.00 | |
| 191_N | 200_S | 1.755 | 1.00 | |
| 94_S | 126_I | 1.736 | 1.00 | |
| 181_R | 227_D | 1.733 | 1.00 | |
| 191_N | 218_D | 1.714 | 1.00 | |
| 60_K | 125_G | 1.713 | 1.00 | |
| 126_I | 157_H | 1.677 | 1.00 | |
| 191_N | 198_K | 1.656 | 1.00 | |
| 91_Q | 130_Y | 1.627 | 1.00 | |
| 56_T | 100_R | 1.614 | 1.00 | |
| 70_E | 111_R | 1.597 | 1.00 | |
| 169_K | 219_S | 1.587 | 1.00 | |
| 45_D | 113_H | 1.564 | 1.00 | |
| 76_Q | 102_S | 1.548 | 1.00 | |
| 217_A | 220_D | 1.525 | 1.00 | |
| 131_E | 155_K | 1.52 | 1.00 | |
| 63_E | 94_S | 1.495 | 1.00 | |
| 96_G | 126_I | 1.491 | 1.00 | |
| 165_W | 173_S | 1.491 | 1.00 | |
| 187_V | 192_V | 1.479 | 1.00 | |
| 56_T | 102_S | 1.476 | 1.00 | |
| 199_A | 203_D | 1.432 | 1.00 | |
| 207_I | 213_I | 1.428 | 1.00 | |
| 69_L | 188_V | 1.42 | 1.00 | |
| 92_I | 131_E | 1.417 | 1.00 | |
| 78_S | 100_R | 1.381 | 0.99 | |
| 72_T | 106_P | 1.373 | 0.99 | |
| 193_T | 218_D | 1.367 | 0.99 | |
| 200_S | 203_D | 1.364 | 0.99 | |
| 117_I | 226_F | 1.353 | 0.99 | |
| 79_M | 99_I | 1.326 | 0.99 | |
| 159_D | 181_R | 1.317 | 0.99 | |
| 168_L | 171_E | 1.312 | 0.99 | |
| 185_I | 225_L | 1.307 | 0.99 | |
| 74_E | 106_P | 1.278 | 0.99 | |
| 176_Q | 212_A | 1.273 | 0.99 | |
| 52_Q | 55_G | 1.257 | 0.99 | |
| 40_L | 44_N | 1.253 | 0.99 | |
| 167_L | 217_A | 1.226 | 0.98 | |
| 59_H | 101_H | 1.225 | 0.98 | |
| 2_I | 205_L | 1.22 | 0.98 | |
| 68_V | 114_L | 1.213 | 0.98 | |
| 215_I | 223_V | 1.204 | 0.98 | |
| 185_I | 207_I | 1.195 | 0.98 | |
| 184_W | 206_A | 1.191 | 0.98 | |
| 73_V | 112_L | 1.186 | 0.98 | |
| 124_N | 146_S | 1.162 | 0.97 | |
| 42_V | 46_D | 1.158 | 0.97 | |
| 84_Q | 106_P | 1.156 | 0.97 | |
| 56_T | 76_Q | 1.156 | 0.97 | |
| 6_K | 9_E | 1.155 | 0.97 | |
| 166_A | 222_E | 1.148 | 0.97 | |
| 192_V | 223_V | 1.147 | 0.97 | |
| 64_I | 93_M | 1.141 | 0.97 | |
| 169_K | 220_D | 1.138 | 0.97 | |
| 178_A | 181_R | 1.135 | 0.97 | |
| 41_R | 44_N | 1.127 | 0.97 | |
| 113_H | 189_K | 1.115 | 0.96 | |
| 45_D | 186_Q | 1.113 | 0.96 | |
| 35_M | 41_R | 1.103 | 0.96 | |
| 75_H | 130_Y | 1.093 | 0.96 | |
| 97_T | 128_P | 1.092 | 0.96 | |
| 146_S | 153_S | 1.089 | 0.96 | |
| 40_L | 43_I | 1.078 | 0.95 | |
| 57_H | 101_H | 1.074 | 0.95 | |
| 70_E | 189_K | 1.069 | 0.95 | |
| 143_L | 147_P | 1.067 | 0.95 | |
| 43_I | 117_I | 1.065 | 0.95 | |
| 5_R | 34_F | 1.06 | 0.95 | |
| 43_I | 226_F | 1.059 | 0.95 | |
| 194_I | 215_I | 1.056 | 0.95 | |
| 39_A | 229_P | 1.055 | 0.95 | |
| 167_L | 171_E | 1.047 | 0.94 | |
| 86_P | 89_E | 1.045 | 0.94 | |
| 146_S | 151_D | 1.034 | 0.94 | |
| 92_I | 129_R | 1.029 | 0.94 | |
| 179_A | 182_R | 1.026 | 0.94 | |
| 184_W | 226_F | 1.025 | 0.93 | |
| 75_H | 103_E | 1.015 | 0.93 | |
| 185_I | 192_V | 1.009 | 0.93 | |
| 20_S | 66_T | 1.007 | 0.93 | |
| 5_R | 9_E | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1tq5A | 1 | 1 | 100 | -0.021 | Contact Map | 0.799 |
| 2vecA | 1 | 0.9827 | 100 | 0.031 | Contact Map | 0.692 |
| 4eweA | 1 | 0.974 | 100 | 0.173 | Contact Map | 0.704 |
| 2p17A | 1 | 0.9654 | 100 | 0.178 | Contact Map | 0.708 |
| 3o14A | 2 | 0.8788 | 99.8 | 0.703 | Contact Map | 0.618 |
| 1sq4A | 2 | 0.9351 | 99.4 | 0.783 | Contact Map | 0.62 |
| 1sefA | 1 | 0.9091 | 99.2 | 0.795 | Contact Map | 0.608 |
| 1rc6A | 2 | 0.9134 | 99.1 | 0.81 | Contact Map | 0.658 |
| 3h7jA | 2 | 0.8701 | 99 | 0.813 | Contact Map | 0.637 |
| 2d40A | 4 | 0.9654 | 99 | 0.813 | Contact Map | 0.568 |
Sequence Conservation (Image Generated using WebLogo v3)