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YHFW - Uncharacterized protein YhfW
UniProt: P45549 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12918
Length: 408 (380)
Sequences: 591
Seq/Len: 1.56
YHFW
Paralog alert: 0.17 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DEOB YHFW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
276_D 319_N 3.646 1.00
283_N 326_A 3.354 1.00
135_N 139_A 3.14 1.00
238_Q 260_P 2.918 1.00
347_H 351_T 2.913 1.00
136_Q 142_D 2.88 1.00
240_L 386_F 2.814 1.00
35_H 38_S 2.719 1.00
278_T 292_T 2.714 1.00
111_V 152_Y 2.648 1.00
126_G 131_F 2.566 1.00
231_D 260_P 2.532 1.00
47_T 50_T 2.435 1.00
138_V 217_Y 2.296 0.99
5_V 290_I 2.281 0.99
234_V 242_E 2.269 0.99
108_I 112_E 2.196 0.99
31_N 34_G 2.194 0.99
300_A 312_R 2.187 0.99
250_V 281_E 2.185 0.99
137_A 206_F 2.155 0.99
319_N 322_R 2.147 0.99
171_R 228_Y 2.118 0.99
264_S 284_T 2.094 0.99
304_E 351_T 2.085 0.99
105_R 109_D 2.048 0.99
112_E 121_Q 2.012 0.98
241_Y 263_V 2.006 0.98
31_N 57_L 1.965 0.98
384_E 396_S 1.945 0.98
165_D 168_K 1.918 0.97
84_T 256_I 1.913 0.97
31_N 61_P 1.882 0.97
275_M 323_L 1.878 0.97
272_Q 276_D 1.877 0.97
359_V 397_F 1.848 0.97
126_G 133_W 1.837 0.96
74_V 371_V 1.824 0.96
85_F 229_G 1.817 0.96
73_G 370_G 1.808 0.96
272_Q 319_N 1.798 0.96
254_A 259_N 1.791 0.96
373_T 395_R 1.781 0.96
225_H 267_N 1.778 0.96
361_Q 364_M 1.777 0.95
21_T 28_A 1.775 0.95
114_A 175_E 1.763 0.95
236_V 383_C 1.759 0.95
91_I 378_V 1.743 0.95
333_L 360_Y 1.721 0.94
345_I 351_T 1.709 0.94
304_E 347_H 1.687 0.94
110_R 114_A 1.644 0.92
2_A 287_T 1.635 0.92
161_I 169_I 1.63 0.92
372_R 377_D 1.629 0.92
306_V 344_T 1.623 0.92
109_D 113_Q 1.604 0.91
275_M 321_A 1.602 0.91
135_N 217_Y 1.602 0.91
143_N 169_I 1.574 0.90
243_A 388_A 1.557 0.89
304_E 345_I 1.55 0.89
45_L 53_L 1.542 0.89
238_Q 242_E 1.54 0.89
35_H 344_T 1.535 0.89
111_V 173_V 1.532 0.88
71_T 364_M 1.505 0.87
330_D 363_G 1.504 0.87
234_V 239_K 1.501 0.87
108_I 122_V 1.494 0.87
75_A 378_V 1.491 0.87
286_P 290_I 1.479 0.86
30_A 347_H 1.477 0.86
50_T 69_S 1.463 0.85
377_D 397_F 1.463 0.85
168_K 171_R 1.461 0.85
231_D 258_N 1.457 0.85
75_A 372_R 1.453 0.85
47_T 321_A 1.446 0.84
45_L 313_L 1.443 0.84
2_A 330_D 1.441 0.84
74_V 354_V 1.441 0.84
55_N 68_D 1.44 0.84
26_Q 346_G 1.419 0.83
138_V 212_P 1.419 0.83
273_R 277_I 1.413 0.82
30_A 345_I 1.403 0.82
76_E 354_V 1.4 0.81
18_K 354_V 1.395 0.81
75_A 357_V 1.395 0.81
237_P 249_L 1.391 0.81
257_V 379_G 1.372 0.80
119_G 173_V 1.369 0.79
4_F 382_V 1.359 0.79
272_Q 315_V 1.349 0.78
275_M 319_N 1.348 0.78
23_V 304_E 1.321 0.76
372_R 397_F 1.32 0.76
23_V 347_H 1.319 0.76
37_L 61_P 1.319 0.76
329_P 362_Q 1.306 0.75
279_L 282_F 1.306 0.75
94_T 233_K 1.301 0.74
20_V 30_A 1.296 0.74
73_G 397_F 1.296 0.74
305_D 311_E 1.291 0.74
272_Q 275_M 1.285 0.73
30_A 351_T 1.265 0.71
364_M 401_L 1.264 0.71
359_V 369_L 1.256 0.71
35_H 351_T 1.248 0.70
277_I 280_N 1.246 0.70
332_C 385_F 1.231 0.68
143_N 161_I 1.228 0.68
77_L 375_L 1.22 0.67
9_I 335_V 1.216 0.67
43_L 314_Q 1.215 0.67
334_V 359_V 1.21 0.66
49_E 63_D 1.207 0.66
92_L 379_G 1.204 0.66
238_Q 241_Y 1.195 0.65
6_V 91_I 1.187 0.64
380_A 391_P 1.184 0.64
114_A 172_I 1.182 0.64
236_V 386_F 1.181 0.64
236_V 391_P 1.17 0.63
50_T 318_R 1.157 0.61
163_F 223_V 1.153 0.61
23_V 236_V 1.153 0.61
112_E 122_V 1.148 0.60
143_N 147_D 1.126 0.58
257_V 291_C 1.114 0.57
212_P 215_G 1.111 0.57
69_S 360_Y 1.106 0.56
111_V 179_V 1.105 0.56
272_Q 322_R 1.103 0.56
235_Q 238_Q 1.102 0.56
45_L 314_Q 1.096 0.55
307_A 311_E 1.096 0.55
110_R 172_I 1.087 0.54
76_E 373_T 1.085 0.54
271_S 312_R 1.079 0.53
241_Y 247_T 1.077 0.53
6_V 382_V 1.074 0.53
355_V 378_V 1.074 0.53
276_D 322_R 1.074 0.53
384_E 398_L 1.072 0.53
321_A 325_E 1.072 0.53
300_A 315_V 1.067 0.52
23_V 80_E 1.051 0.50
107_V 177_V 1.051 0.50
49_E 55_N 1.05 0.50
37_L 43_L 1.05 0.50
282_F 323_L 1.049 0.50
40_L 310_A 1.046 0.50
102_M 179_V 1.044 0.50
38_S 387_R 1.042 0.50
107_V 176_Q 1.038 0.49
6_V 289_F 1.038 0.49
369_L 386_F 1.037 0.49
9_I 320_L 1.035 0.49
306_V 310_A 1.034 0.49
225_H 228_Y 1.031 0.48
240_L 245_V 1.028 0.48
54_I 64_M 1.027 0.48
142_D 225_H 1.022 0.47
178_Q 229_G 1.02 0.47
110_R 113_Q 1.02 0.47
246_P 264_S 1.019 0.47
71_T 361_Q 1.016 0.47
228_Y 260_P 1.016 0.47
180_G 275_M 1.01 0.46
245_V 289_F 1.009 0.46
160_V 209_I 1.007 0.46
84_T 309_Y 1.005 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ot9A30.91421000.406Contact Map0.689
2i09A20.90691000.41Contact Map0.657
3kd8A20.83821000.789Contact Map0.388
2w0yA20.784399.90.845Contact Map0.303
1zedA10.899599.90.85Contact Map0.291
2zktA20.82699.90.852Contact Map0.386
1o98A10.882499.90.863Contact Map0.493
1k7hA20.865299.90.863Contact Map0.327
3tg0A40.828499.90.867Contact Map0.35
3a52A20.735399.90.87Contact Map0.388
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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