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OPENSEQ.org
DEOB - Phosphopentomutase
UniProt: P0A6K6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10220
Length: 407 (406)
Sequences: 592
Seq/Len: 1.46
DEOB
Paralog alert: 0.17 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DEOB YHFW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
290_K 335_L 4.38 1.00
283_D 328_R 3.502 1.00
143_G 152_I 3.334 1.00
126_Q 130_D 3.202 1.00
158_E 162_K 3.011 1.00
135_R 199_E 2.767 1.00
132_L 197_A 2.765 1.00
356_G 360_T 2.754 1.00
159_E 165_K 2.731 1.00
133_V 140_G 2.712 1.00
143_G 156_L 2.696 1.00
152_I 156_L 2.657 1.00
244_Q 267_C 2.656 1.00
117_F 206_Y 2.609 1.00
285_T 300_T 2.588 1.00
33_H 36_E 2.54 1.00
132_L 176_F 2.497 1.00
151_V 154_D 2.471 1.00
152_I 155_Q 2.47 1.00
246_L 395_F 2.414 1.00
161_M 224_F 2.355 1.00
142_L 159_E 2.334 0.99
236_E 267_C 2.327 0.99
160_H 216_F 2.32 0.99
145_C 155_Q 2.261 0.99
247_V 270_T 2.243 0.99
240_P 248_D 2.14 0.99
55_N 58_R 2.131 0.99
309_W 321_G 2.085 0.99
5_F 298_V 2.067 0.98
98_T 263_I 2.065 0.98
147_S 152_I 2.045 0.98
29_D 32_G 2.042 0.98
257_V 288_E 2.026 0.98
35_A 75_G 2.002 0.98
29_D 69_T 1.997 0.98
143_G 147_S 1.989 0.98
328_R 331_E 1.986 0.98
271_K 291_E 1.973 0.98
147_S 155_Q 1.952 0.97
313_R 360_T 1.939 0.97
187_L 229_N 1.913 0.97
158_E 224_F 1.902 0.97
29_D 65_H 1.864 0.96
393_K 405_A 1.853 0.96
189_K 192_E 1.829 0.96
195_E 233_L 1.825 0.96
279_D 283_D 1.796 0.95
21_E 26_V 1.78 0.95
368_V 406_M 1.769 0.95
87_A 379_G 1.752 0.94
147_S 156_L 1.752 0.94
166_P 193_L 1.752 0.94
282_F 332_L 1.731 0.94
131_K 135_R 1.727 0.94
279_D 328_R 1.714 0.93
129_L 133_V 1.714 0.93
261_A 266_N 1.688 0.93
381_R 386_D 1.686 0.93
88_W 380_H 1.673 0.92
99_P 234_A 1.663 0.92
231_H 274_K 1.651 0.92
105_I 387_I 1.65 0.92
370_G 373_V 1.648 0.92
315_V 353_T 1.631 0.91
130_D 134_E 1.618 0.91
354_W 360_T 1.616 0.91
129_L 141_Y 1.61 0.90
185_F 193_L 1.584 0.89
382_E 404_K 1.582 0.89
142_L 165_K 1.577 0.89
313_R 356_G 1.575 0.89
128_L 206_Y 1.559 0.88
242_V 392_A 1.525 0.87
342_L 369_Y 1.524 0.87
33_H 353_T 1.511 0.86
131_K 134_E 1.491 0.85
313_R 354_W 1.482 0.85
282_F 330_P 1.48 0.85
89_A 387_I 1.465 0.84
386_D 406_M 1.457 0.83
140_G 165_K 1.452 0.83
53_L 322_L 1.45 0.83
161_M 184_T 1.445 0.83
28_A 356_G 1.441 0.82
85_A 373_V 1.437 0.82
166_P 185_F 1.434 0.82
250_K 397_T 1.433 0.82
240_P 245_K 1.432 0.82
1_M 373_V 1.43 0.82
24_G 355_T 1.411 0.81
339_D 372_K 1.395 0.79
58_R 83_I 1.392 0.79
192_E 195_E 1.391 0.79
293_G 298_V 1.388 0.79
89_A 381_R 1.386 0.79
143_G 155_Q 1.385 0.79
53_L 61_L 1.378 0.78
135_R 196_I 1.378 0.78
88_W 363_H 1.371 0.78
282_F 328_R 1.371 0.78
2_K 294_D 1.369 0.78
28_A 354_W 1.354 0.77
89_A 366_V 1.352 0.76
236_E 265_A 1.349 0.76
381_R 406_M 1.339 0.75
133_V 141_Y 1.337 0.75
219_D 223_N 1.319 0.74
63_K 82_V 1.299 0.72
243_L 256_S 1.297 0.72
151_V 155_Q 1.293 0.72
279_D 324_L 1.29 0.72
244_Q 248_D 1.289 0.71
159_E 162_K 1.285 0.71
279_D 282_F 1.279 0.71
20_A 28_A 1.276 0.70
23_F 356_G 1.268 0.70
280_A 284_A 1.261 0.69
90_H 363_H 1.252 0.68
18_E 363_H 1.252 0.68
182_E 229_N 1.25 0.68
256_S 269_I 1.245 0.68
154_D 222_G 1.243 0.67
264_Y 388_G 1.231 0.66
4_A 391_L 1.228 0.66
115_G 208_I 1.218 0.65
204_G 208_I 1.215 0.65
23_F 313_R 1.213 0.65
55_N 330_P 1.201 0.64
254_V 270_T 1.201 0.64
91_E 384_F 1.195 0.63
161_M 221_A 1.193 0.63
314_D 320_A 1.186 0.62
28_A 360_T 1.185 0.62
338_D 371_P 1.181 0.62
108_V 238_P 1.173 0.61
57_T 77_D 1.163 0.60
33_H 360_T 1.157 0.59
9_L 344_L 1.155 0.59
242_V 395_F 1.149 0.59
341_I 394_Y 1.132 0.57
87_A 406_M 1.13 0.57
85_A 375_P 1.128 0.56
287_K 291_E 1.124 0.56
389_Q 400_M 1.124 0.56
62_A 76_M 1.117 0.55
36_E 74_A 1.116 0.55
100_S 114_W 1.115 0.55
2_K 339_D 1.093 0.53
132_L 168_F 1.084 0.52
6_I 105_I 1.084 0.52
244_Q 247_V 1.082 0.52
6_I 391_L 1.079 0.51
316_A 320_A 1.073 0.51
368_V 378_L 1.072 0.51
106_A 388_G 1.07 0.50
284_A 287_K 1.068 0.50
51_L 75_G 1.067 0.50
233_L 267_C 1.061 0.50
90_H 382_E 1.057 0.49
53_L 323_E 1.056 0.49
264_Y 299_F 1.056 0.49
217_I 225_Q 1.055 0.49
309_W 324_L 1.053 0.49
160_H 166_P 1.052 0.49
38_C 319_A 1.048 0.48
51_L 323_E 1.048 0.48
273_V 288_E 1.046 0.48
98_T 318_Y 1.045 0.48
241_T 244_Q 1.04 0.47
286_I 289_M 1.038 0.47
247_V 254_V 1.038 0.47
142_L 216_F 1.037 0.47
343_I 368_V 1.034 0.47
364_I 387_I 1.034 0.47
139_P 166_P 1.031 0.46
44_D 48_K 1.024 0.46
1_M 394_Y 1.021 0.45
255_V 293_G 1.015 0.45
58_R 327_R 1.011 0.44
35_A 51_L 1.011 0.44
242_V 400_M 1.01 0.44
393_K 407_F 1.006 0.44
6_I 297_I 1.006 0.44
278_L 321_G 1.004 0.44
283_D 331_E 1.001 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i09A20.93861000.357Contact Map0.717
3ot9A30.9411000.358Contact Map0.766
3kd8A20.86981000.786Contact Map0.356
2w0yA20.79361000.84Contact Map0.291
2zktA20.8551000.848Contact Map0.369
1zedA10.823199.90.857Contact Map0.299
1k7hA20.850199.90.867Contact Map0.325
1o98A10.953399.90.87Contact Map0.441
3tg0A40.808499.90.871Contact Map0.365
3igzB10.968199.90.876Contact Map0.402
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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