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OPENSEQ.org
YHBU - Uncharacterized protease YhbU
UniProt: P45527 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12790
Length: 331 (327)
Sequences: 1559
Seq/Len: 4.77
YHBU
Paralog alert: 0.72 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: YDCP YEGQ YHBU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_L 292_I 3.752 1.00
289_R 293_D 3.731 1.00
5_C 285_A 3.49 1.00
54_V 61_L 3.357 1.00
114_V 135_V 3.118 1.00
17_I 59_R 3.023 1.00
100_L 135_V 2.994 1.00
55_H 90_D 2.709 1.00
77_W 99_M 2.672 1.00
18_E 53_F 2.635 1.00
153_A 267_A 2.485 1.00
17_I 53_F 2.459 1.00
51_V 89_A 2.415 1.00
262_M 292_I 2.38 1.00
26_I 61_L 2.375 1.00
111_E 136_A 2.319 1.00
126_I 138_V 2.305 1.00
150_K 263_A 2.279 1.00
63_I 84_A 2.266 1.00
258_L 295_C 2.231 1.00
92_L 110_I 2.215 1.00
4_L 268_S 2.197 1.00
48_Q 52_S 2.185 1.00
311_T 314_S 2.179 1.00
153_A 160_L 2.15 1.00
65_I 81_V 2.125 1.00
261_L 269_V 2.122 1.00
43_T 46_K 2.032 1.00
137_R 159_P 2.029 1.00
10_L 50_A 2.015 1.00
150_K 154_R 2.004 1.00
65_I 77_W 1.99 1.00
44_E 83_M 1.937 1.00
262_M 269_V 1.903 1.00
162_V 261_L 1.88 1.00
259_P 263_A 1.87 1.00
52_S 56_Q 1.837 1.00
14_K 49_E 1.83 1.00
254_T 257_L 1.812 1.00
13_L 50_A 1.801 1.00
298_D 301_N 1.762 1.00
14_K 53_F 1.75 1.00
63_I 89_A 1.747 1.00
127_N 131_R 1.699 0.99
71_P 123_E 1.675 0.99
271_I 285_A 1.657 0.99
19_N 282_S 1.633 0.99
26_I 47_L 1.631 0.99
51_V 87_L 1.626 0.99
45_K 48_Q 1.625 0.99
18_E 57_H 1.615 0.99
256_E 309_M 1.573 0.99
146_I 264_A 1.564 0.99
50_A 61_L 1.549 0.99
17_I 57_H 1.532 0.99
28_L 80_A 1.528 0.99
100_L 114_V 1.525 0.99
16_A 281_V 1.523 0.99
286_K 290_Q 1.521 0.99
81_V 103_A 1.499 0.98
12_A 278_P 1.486 0.98
53_F 57_H 1.477 0.98
23_A 268_S 1.474 0.98
262_M 295_C 1.459 0.98
114_V 118_A 1.452 0.98
10_L 49_E 1.451 0.98
198_F 201_W 1.443 0.98
103_A 112_R 1.439 0.98
147_H 150_K 1.428 0.98
101_E 105_E 1.415 0.97
126_I 158_V 1.413 0.97
4_L 23_A 1.395 0.97
27_G 33_N 1.386 0.97
84_A 89_A 1.383 0.97
323_L 327_H 1.382 0.97
3_L 289_R 1.379 0.97
200_R 203_Q 1.374 0.97
262_M 296_K 1.371 0.97
258_L 292_I 1.365 0.96
91_A 113_H 1.358 0.96
151_Q 155_V 1.347 0.96
120_A 126_I 1.338 0.96
306_S 310_E 1.336 0.96
162_V 266_I 1.331 0.96
140_L 160_L 1.331 0.96
120_A 125_A 1.329 0.96
1_M 262_M 1.323 0.96
140_L 162_V 1.318 0.95
85_A 109_H 1.314 0.95
5_C 271_I 1.308 0.95
97_L 128_F 1.306 0.95
17_I 54_V 1.294 0.95
253_N 256_E 1.293 0.95
49_E 52_S 1.292 0.95
94_L 112_R 1.284 0.95
68_F 95_A 1.28 0.94
255_L 287_V 1.275 0.94
105_E 127_N 1.27 0.94
9_N 12_A 1.267 0.94
123_E 155_V 1.251 0.94
15_A 19_N 1.226 0.93
150_K 260_E 1.221 0.92
10_L 14_K 1.219 0.92
92_L 112_R 1.214 0.92
112_R 135_V 1.203 0.92
41_N 275_Q 1.195 0.91
140_L 152_L 1.192 0.91
13_L 54_V 1.186 0.91
196_A 201_W 1.174 0.90
26_I 63_I 1.172 0.90
46_K 49_E 1.17 0.90
130_H 158_V 1.159 0.90
165_F 288_W 1.153 0.89
128_F 133_F 1.153 0.89
255_L 291_A 1.152 0.89
127_N 155_V 1.15 0.89
124_E 127_N 1.136 0.88
51_V 61_L 1.132 0.88
153_A 266_I 1.128 0.88
92_L 103_A 1.126 0.88
117_Q 188_N 1.123 0.88
9_N 39_G 1.115 0.87
149_V 264_A 1.113 0.87
97_L 129_Y 1.112 0.87
3_L 284_V 1.112 0.87
55_H 61_L 1.112 0.87
64_A 326_Y 1.107 0.87
269_V 292_I 1.096 0.86
204_T 207_G 1.091 0.85
82_D 107_Y 1.085 0.85
130_H 157_P 1.084 0.85
50_A 54_V 1.077 0.84
144_L 149_V 1.075 0.84
26_I 42_F 1.07 0.84
180_S 186_S 1.067 0.84
131_R 157_P 1.065 0.84
290_Q 305_Q 1.064 0.83
116_V 141_P 1.056 0.83
83_M 87_L 1.053 0.83
78_Q 105_E 1.046 0.82
233_K 236_Y 1.045 0.82
2_E 268_S 1.042 0.82
51_V 55_H 1.041 0.82
54_V 59_R 1.039 0.81
36_H 192_A 1.036 0.81
198_F 203_Q 1.032 0.81
73_G 189_T 1.026 0.80
103_A 107_Y 1.021 0.80
218_D 221_Q 1.02 0.80
94_L 99_M 1.016 0.79
80_A 84_A 1.008 0.79
264_A 269_V 1.005 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bdqA20.601298.40.912Contact Map0.541
3f4wA20.416997.10.934Contact Map0.756
3iixA10.519696.90.936Contact Map0.532
2ftpA10.558996.90.936Contact Map0.587
1ydoA40.580196.80.936Contact Map0.547
1ydnA40.555996.60.938Contact Map0.489
3qjaA10.441196.60.938Contact Map0.67
3tsmA20.404896.40.939Contact Map0.674
4axkA20.444196.40.939Contact Map0.601
3iwpA120.643596.40.939Contact Map0.629
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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