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OPENSEQ.org
YEGQ - Uncharacterized protease YegQ
UniProt: P76403 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14060
Length: 453 (417)
Sequences: 1037
Seq/Len: 2.49
YEGQ
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: YDCP YEGQ YHBU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
407_N 411_E 4.561 1.00
8_S 302_A 4.222 1.00
115_L 135_L 3.751 1.00
306_R 310_D 3.495 1.00
20_F 60_K 3.025 1.00
49_Q 53_N 2.974 1.00
101_I 135_L 2.951 1.00
6_L 309_I 2.881 1.00
112_P 136_T 2.735 1.00
55_A 62_F 2.654 1.00
389_L 402_L 2.651 1.00
13_L 51_G 2.605 1.00
72_N 124_W 2.519 1.00
52_I 90_P 2.452 1.00
278_L 286_L 2.391 1.00
404_H 412_A 2.379 1.00
277_R 340_R 2.347 1.00
127_V 138_V 2.313 1.00
4_P 313_A 2.278 1.00
131_Q 159_M 2.262 1.00
279_T 309_I 2.256 1.00
150_E 154_N 2.221 1.00
276_E 280_K 2.216 1.00
56_H 91_D 2.194 1.00
153_R 284_H 2.162 1.00
17_R 54_E 2.117 1.00
101_I 115_L 2.096 1.00
150_E 280_K 2.082 1.00
388_S 399_N 2.078 1.00
98_P 129_F 2.061 1.00
163_I 278_L 2.031 0.99
53_N 57_A 1.982 0.99
275_V 309_I 1.981 0.99
153_R 161_I 1.979 0.99
275_V 312_A 1.932 0.99
20_F 54_E 1.924 0.99
127_V 159_M 1.913 0.99
93_L 111_M 1.911 0.99
137_R 160_E 1.907 0.99
368_G 376_A 1.895 0.99
21_A 54_E 1.855 0.99
273_A 323_L 1.848 0.99
66_V 78_F 1.825 0.99
382_K 415_I 1.818 0.99
283_V 339_L 1.801 0.98
8_S 288_I 1.799 0.98
7_L 285_S 1.797 0.98
303_Q 307_K 1.786 0.98
364_G 377_V 1.785 0.98
78_F 100_L 1.785 0.98
121_A 126_T 1.752 0.98
46_E 49_Q 1.701 0.98
271_A 274_H 1.698 0.98
272_I 304_V 1.685 0.97
12_T 15_N 1.671 0.97
44_N 47_N 1.66 0.97
151_E 155_Q 1.659 0.97
29_A 62_F 1.627 0.97
128_K 131_Q 1.611 0.96
288_I 302_A 1.594 0.96
52_I 88_M 1.592 0.96
274_H 336_E 1.589 0.96
20_F 58_L 1.565 0.95
271_A 339_L 1.545 0.95
22_Y 299_A 1.522 0.94
391_L 400_F 1.504 0.94
400_F 428_P 1.499 0.94
279_T 286_L 1.476 0.93
146_L 281_M 1.474 0.93
331_H 334_Y 1.461 0.93
12_T 41_N 1.458 0.93
93_L 104_V 1.458 0.93
376_A 424_W 1.437 0.92
42_E 292_T 1.431 0.92
69_A 96_S 1.427 0.92
66_V 79_I 1.426 0.92
6_L 306_R 1.42 0.91
105_R 132_Q 1.419 0.91
383_F 423_V 1.418 0.91
4_P 279_T 1.41 0.91
286_L 326_L 1.385 0.90
17_R 50_L 1.382 0.90
274_H 340_R 1.353 0.88
131_Q 158_D 1.353 0.88
377_V 425_L 1.345 0.88
270_R 273_A 1.339 0.88
163_I 283_V 1.339 0.88
29_A 48_L 1.324 0.87
74_K 190_Q 1.318 0.87
51_G 62_F 1.313 0.86
31_Q 81_D 1.305 0.86
21_A 58_L 1.301 0.86
92_A 114_H 1.301 0.86
243_E 249_G 1.3 0.86
13_L 50_L 1.29 0.85
140_L 161_I 1.283 0.85
3_K 313_A 1.283 0.85
131_Q 156_V 1.282 0.85
30_G 35_S 1.281 0.84
121_A 127_V 1.278 0.84
406_E 412_A 1.276 0.84
40_N 292_T 1.268 0.84
387_D 440_R 1.26 0.83
124_W 155_Q 1.258 0.83
54_E 58_L 1.257 0.83
16_M 51_G 1.254 0.83
388_S 401_T 1.252 0.83
200_E 245_A 1.25 0.82
18_Y 22_Y 1.242 0.82
140_L 152_I 1.242 0.82
95_M 101_I 1.239 0.82
104_V 113_I 1.239 0.82
242_I 264_M 1.236 0.81
379_V 383_F 1.233 0.81
272_I 308_A 1.23 0.81
13_L 54_E 1.229 0.81
320_T 324_E 1.224 0.81
181_G 187_D 1.222 0.80
336_E 340_R 1.217 0.80
82_L 104_V 1.216 0.80
375_A 427_V 1.198 0.79
274_H 277_R 1.198 0.79
363_V 389_L 1.188 0.78
271_A 336_E 1.183 0.77
184_N 194_T 1.182 0.77
163_I 339_L 1.175 0.77
244_E 247_R 1.172 0.76
279_T 313_A 1.171 0.76
405_M 425_L 1.167 0.76
112_P 160_E 1.163 0.76
128_K 155_Q 1.162 0.76
29_A 55_A 1.161 0.75
374_L 424_W 1.16 0.75
38_V 192_T 1.16 0.75
311_D 322_L 1.16 0.75
71_H 148_E 1.159 0.75
127_V 156_V 1.156 0.75
15_N 295_F 1.155 0.75
6_L 10_A 1.153 0.75
20_F 55_A 1.146 0.74
325_T 328_G 1.139 0.73
244_E 249_G 1.138 0.73
14_K 365_E 1.134 0.73
128_K 132_Q 1.131 0.73
129_F 133_M 1.13 0.73
147_E 277_R 1.127 0.72
6_L 310_D 1.126 0.72
127_V 152_I 1.125 0.72
169_L 335_T 1.124 0.72
75_L 82_L 1.115 0.71
64_V 90_P 1.113 0.71
93_L 113_I 1.112 0.71
26_A 285_S 1.111 0.71
400_F 427_V 1.11 0.71
36_L 292_T 1.108 0.71
367_T 378_A 1.104 0.70
280_K 312_A 1.098 0.70
144_L 148_E 1.094 0.69
94_I 286_L 1.09 0.69
64_V 85_V 1.086 0.68
279_T 312_A 1.077 0.67
106_E 128_K 1.077 0.67
375_A 431_L 1.072 0.67
156_V 159_M 1.065 0.66
416_A 423_V 1.064 0.66
117_V 141_S 1.063 0.66
151_E 154_N 1.061 0.66
389_L 400_F 1.059 0.65
196_A 201_Y 1.056 0.65
404_H 426_P 1.055 0.65
149_I 152_I 1.055 0.65
51_G 55_A 1.052 0.65
98_P 130_W 1.05 0.65
94_I 129_F 1.049 0.64
48_L 88_M 1.046 0.64
166_H 305_Y 1.045 0.64
49_Q 88_M 1.043 0.64
405_M 416_A 1.039 0.63
402_L 405_M 1.039 0.63
86_V 110_E 1.03 0.62
106_E 132_Q 1.026 0.62
32_P 41_N 1.026 0.62
329_L 334_Y 1.024 0.62
32_P 47_N 1.022 0.61
97_D 168_A 1.02 0.61
150_E 277_R 1.019 0.61
247_R 251_Y 1.019 0.61
406_E 410_G 1.018 0.61
120_N 176_R 1.018 0.61
301_T 326_L 1.015 0.61
383_F 402_L 1.014 0.61
271_A 340_R 1.003 0.59
19_A 298_C 1.002 0.59
52_I 56_H 1.001 0.59
203_V 263_I 1 0.59
163_I 286_L 1 0.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4he6A10.192199.40.915Contact Map0.949
2bdqA20.417298.50.941Contact Map0.454
3f4wA20.311397.30.955Contact Map0.712
3q58A20.300296.90.958Contact Map0.695
3tsmA20.304696.90.958Contact Map0.642
3igsA20.306896.70.959Contact Map0.638
3iwpA120.470296.40.96Contact Map0.564
4ml9A20.317996.30.961Contact Map0.574
2e6fA20.379796.30.961Contact Map0.594
4axkA20.331196.30.961Contact Map0.537
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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