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OPENSEQ.org
TDCG - L-serine dehydratase TdcG
UniProt: P42630 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12756
Length: 454 (452)
Sequences: 874
Seq/Len: 1.93
TDCG
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: SDHL SDHM TDCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
189_S 356_E 3.595 1.00
337_V 341_G 3.581 1.00
264_I 404_V 3.385 1.00
373_M 424_V 3.291 1.00
210_A 313_A 3.055 1.00
355_T 360_G 3.002 1.00
220_I 298_A 2.992 1.00
128_R 142_T 2.829 1.00
197_L 202_K 2.81 1.00
314_R 356_E 2.759 1.00
347_C 372_A 2.631 1.00
71_A 86_F 2.609 1.00
325_L 425_I 2.576 1.00
197_L 205_I 2.508 1.00
182_D 363_A 2.498 1.00
265_N 405_N 2.425 1.00
201_S 204_E 2.399 1.00
326_Y 345_V 2.376 1.00
355_T 407_A 2.322 1.00
44_H 112_N 2.312 1.00
179_K 183_Y 2.311 1.00
326_Y 348_S 2.298 1.00
67_I 90_V 2.231 1.00
180_M 184_N 2.21 1.00
95_R 104_I 2.207 1.00
91_T 109_V 2.142 0.99
177_L 191_L 2.133 0.99
210_A 309_E 2.105 0.99
300_Y 311_S 2.077 0.99
94_G 108_P 2.074 0.99
426_E 430_E 2.062 0.99
180_M 191_L 2.062 0.99
44_H 132_W 2.048 0.99
71_A 90_V 2.023 0.99
8_F 319_A 2.021 0.99
244_R 248_V 2.016 0.99
194_H 197_L 2.012 0.99
108_P 111_K 1.982 0.99
209_F 316_F 1.977 0.99
189_S 314_R 1.96 0.99
322_I 352_A 1.96 0.99
34_E 102_A 1.909 0.98
88_E 92_R 1.888 0.98
32_R 139_L 1.874 0.98
89_L 93_S 1.859 0.98
206_D 313_A 1.816 0.97
222_R 274_E 1.787 0.97
9_K 24_N 1.787 0.97
331_S 337_V 1.786 0.97
122_R 144_Y 1.765 0.97
176_E 179_K 1.755 0.97
360_G 411_M 1.727 0.96
331_S 341_G 1.725 0.96
334_G 397_A 1.724 0.96
233_P 387_Q 1.724 0.96
43_S 133_K 1.71 0.96
46_V 130_T 1.704 0.96
120_L 126_G 1.692 0.96
10_I 211_R 1.691 0.96
326_Y 373_M 1.689 0.96
193_M 206_D 1.664 0.95
48_D 130_T 1.643 0.95
130_T 137_E 1.622 0.94
46_V 132_W 1.615 0.94
181_C 362_P 1.605 0.94
4_A 320_G 1.601 0.94
169_Y 194_H 1.595 0.94
201_S 205_I 1.581 0.93
434_D 439_Y 1.58 0.93
265_N 398_I 1.565 0.93
108_P 112_N 1.557 0.93
43_S 134_G 1.543 0.92
49_L 66_I 1.535 0.92
206_D 309_E 1.529 0.92
130_T 140_S 1.528 0.92
361_S 364_Q 1.522 0.91
202_K 206_D 1.519 0.91
256_D 408_R 1.518 0.91
419_V 451_V 1.51 0.91
292_I 379_L 1.507 0.91
200_R 204_E 1.495 0.90
218_D 222_R 1.495 0.90
137_E 140_S 1.491 0.90
219_G 281_V 1.489 0.90
214_Q 218_D 1.474 0.90
366_C 417_P 1.465 0.89
356_E 365_V 1.464 0.89
28_S 151_I 1.451 0.89
132_W 137_E 1.445 0.88
48_D 116_H 1.44 0.88
45_I 98_V 1.44 0.88
27_K 31_D 1.437 0.88
237_P 416_A 1.429 0.88
269_L 397_A 1.428 0.87
186_L 191_L 1.414 0.87
227_E 245_R 1.411 0.87
190_G 194_H 1.407 0.86
39_L 103_H 1.397 0.86
186_L 194_H 1.396 0.86
229_V 235_N 1.382 0.85
390_I 418_R 1.378 0.85
241_V 245_R 1.375 0.85
367_N 417_P 1.374 0.85
63_D 115_F 1.356 0.84
217_H 298_A 1.35 0.83
310_R 314_R 1.343 0.83
172_H 328_M 1.339 0.82
169_Y 184_N 1.323 0.81
67_I 113_I 1.322 0.81
206_D 210_A 1.312 0.81
81_D 105_V 1.307 0.80
200_R 208_G 1.296 0.80
9_K 76_Q 1.294 0.79
348_S 373_M 1.293 0.79
67_I 71_A 1.292 0.79
362_P 365_V 1.286 0.79
334_G 337_V 1.281 0.78
345_V 399_N 1.271 0.78
301_D 312_I 1.265 0.77
292_I 400_A 1.264 0.77
398_I 405_N 1.264 0.77
86_F 90_V 1.26 0.77
58_K 63_D 1.254 0.76
221_E 225_N 1.248 0.76
399_N 409_M 1.247 0.76
318_A 356_E 1.241 0.75
367_N 413_R 1.24 0.75
366_C 415_S 1.226 0.74
74_S 77_D 1.224 0.74
309_E 313_A 1.222 0.74
421_L 425_I 1.222 0.74
66_I 127_M 1.22 0.74
376_N 379_L 1.219 0.73
129_I 142_T 1.217 0.73
54_S 117_P 1.202 0.72
263_W 303_F 1.194 0.71
213_W 312_I 1.192 0.71
42_T 138_L 1.192 0.71
88_E 91_T 1.185 0.70
40_T 103_H 1.184 0.70
170_D 195_N 1.179 0.70
26_G 129_I 1.177 0.70
197_L 201_S 1.169 0.69
347_C 376_N 1.163 0.68
97_P 104_I 1.159 0.68
193_M 202_K 1.156 0.68
208_G 212_I 1.154 0.68
39_L 98_V 1.146 0.67
345_V 373_M 1.144 0.67
224_M 244_R 1.143 0.66
94_G 109_V 1.143 0.66
41_A 138_L 1.139 0.66
413_R 417_P 1.139 0.66
27_K 74_S 1.136 0.66
236_V 279_G 1.136 0.66
2_I 328_M 1.132 0.65
171_F 321_A 1.128 0.65
5_F 208_G 1.126 0.65
172_H 176_E 1.125 0.65
331_S 432_G 1.118 0.64
71_A 97_P 1.116 0.64
87_I 91_T 1.112 0.63
347_C 399_N 1.112 0.63
427_T 447_L 1.11 0.63
175_G 179_K 1.107 0.63
213_W 217_H 1.102 0.62
46_V 114_I 1.094 0.61
189_S 318_A 1.088 0.61
13_G 18_H 1.082 0.60
173_S 176_E 1.082 0.60
146_V 220_I 1.076 0.60
229_V 233_P 1.073 0.59
311_S 357_L 1.071 0.59
141_K 155_E 1.07 0.59
43_S 136_E 1.068 0.59
14_P 18_H 1.065 0.58
331_S 334_G 1.063 0.58
13_G 17_S 1.063 0.58
372_A 376_N 1.063 0.58
250_S 412_R 1.061 0.58
81_D 222_R 1.058 0.58
203_A 207_A 1.058 0.58
95_R 106_D 1.052 0.57
86_F 89_L 1.049 0.57
119_M 124_E 1.049 0.57
256_D 348_S 1.046 0.56
337_V 432_G 1.045 0.56
141_K 153_E 1.045 0.56
401_V 405_N 1.044 0.56
30_I 98_V 1.04 0.56
120_L 142_T 1.04 0.56
10_I 215_V 1.039 0.56
58_K 437_D 1.038 0.55
211_R 214_Q 1.038 0.55
233_P 384_V 1.029 0.54
73_N 86_F 1.027 0.54
206_D 310_R 1.023 0.54
13_G 16_S 1.023 0.54
188_I 318_A 1.021 0.54
54_S 62_T 1.02 0.53
58_K 115_F 1.015 0.53
247_L 263_W 1.013 0.53
348_S 408_R 1.013 0.53
89_L 92_R 1.011 0.52
329_N 334_G 1.008 0.52
310_R 313_A 1.007 0.52
29_F 131_A 1.003 0.52
46_V 140_S 1.002 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iafA10.32821000.729Contact Map0.852
1ygyA20.440598.90.939Contact Map0.434
2hp0A10.563930.30.983Contact Map0.371
1vs1A40.154290.986Contact Map0.688
3tsoC20.15868.20.987Contact Map0.533
4c4pB10.21595.80.988Contact Map0.356
2gzdC20.21595.80.988Contact Map0.302
1wotA10.21155.70.988Contact Map0.246
3tmlA40.1745.60.988Contact Map0.407
2nptA20.21595.40.988Contact Map0.378
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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