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OPENSEQ.org
SDHL - L-serine dehydratase 1
UniProt: P16095 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10930
Length: 454 (452)
Sequences: 872
Seq/Len: 1.93
SDHL
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: SDHL SDHM TDCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
337_V 341_G 3.629 1.00
189_S 356_E 3.564 1.00
264_V 404_I 3.293 1.00
373_M 424_V 3.292 1.00
210_A 313_T 3.046 1.00
220_I 298_A 2.991 1.00
128_Q 142_T 2.909 1.00
197_L 202_K 2.903 1.00
355_A 360_G 2.897 1.00
314_R 356_E 2.734 1.00
71_A 86_F 2.613 1.00
347_C 372_G 2.594 1.00
182_N 363_E 2.501 1.00
325_L 425_I 2.499 1.00
197_L 205_I 2.457 1.00
265_N 405_N 2.413 1.00
326_Y 345_V 2.39 1.00
95_R 104_E 2.373 1.00
355_A 407_A 2.343 1.00
44_R 112_G 2.294 1.00
326_Y 348_S 2.282 1.00
201_S 204_E 2.226 1.00
67_I 90_V 2.223 1.00
180_Y 184_T 2.159 0.99
91_E 109_R 2.137 0.99
210_A 309_P 2.104 0.99
179_A 183_E 2.083 0.99
194_Q 197_L 2.082 0.99
44_R 132_Y 2.081 0.99
300_Y 311_I 2.061 0.99
426_E 430_E 2.037 0.99
108_P 111_N 2.035 0.99
177_L 191_L 2.033 0.99
71_A 90_V 2.03 0.99
180_Y 191_L 2.029 0.99
8_F 319_A 1.991 0.99
94_E 108_P 1.984 0.99
244_R 248_V 1.976 0.99
322_I 352_A 1.952 0.99
34_V 102_R 1.944 0.99
209_F 316_F 1.931 0.98
189_S 314_R 1.924 0.98
89_D 93_R 1.875 0.98
88_R 92_E 1.872 0.98
206_D 313_T 1.865 0.98
32_D 139_Y 1.843 0.98
176_E 179_A 1.788 0.97
331_S 337_V 1.785 0.97
222_R 274_E 1.775 0.97
122_L 144_Y 1.768 0.97
9_K 24_K 1.732 0.96
331_S 341_G 1.723 0.96
334_G 397_A 1.719 0.96
46_A 130_H 1.712 0.96
43_T 133_N 1.709 0.96
233_P 387_Q 1.704 0.96
10_V 211_H 1.691 0.96
120_L 126_G 1.689 0.96
326_Y 373_M 1.685 0.96
360_G 411_L 1.682 0.96
4_L 320_G 1.669 0.95
130_H 137_V 1.663 0.95
48_D 130_H 1.647 0.95
434_D 439_Y 1.645 0.95
46_A 132_Y 1.607 0.94
181_C 362_P 1.605 0.94
193_M 206_D 1.599 0.94
419_V 451_V 1.585 0.93
265_N 398_I 1.557 0.93
202_K 206_D 1.557 0.93
256_D 408_R 1.545 0.92
186_Y 194_Q 1.539 0.92
219_C 281_V 1.519 0.91
169_Y 194_Q 1.516 0.91
130_H 140_S 1.51 0.91
108_P 112_G 1.505 0.91
43_T 134_G 1.5 0.91
206_D 309_P 1.495 0.90
49_V 66_I 1.494 0.90
361_S 364_Q 1.492 0.90
218_A 222_R 1.486 0.90
269_L 397_A 1.48 0.90
45_V 98_L 1.476 0.90
201_S 205_I 1.476 0.90
39_L 103_H 1.467 0.89
132_Y 137_V 1.459 0.89
366_C 417_P 1.459 0.89
28_Q 151_I 1.458 0.89
214_Q 218_A 1.456 0.89
48_D 116_H 1.451 0.89
227_E 245_R 1.449 0.88
169_Y 184_T 1.442 0.88
237_P 416_A 1.434 0.88
292_I 379_L 1.433 0.88
356_E 365_V 1.431 0.88
27_K 31_D 1.428 0.87
186_Y 191_L 1.408 0.86
241_S 245_R 1.403 0.86
229_V 235_R 1.4 0.86
190_G 194_Q 1.394 0.86
137_V 140_S 1.394 0.86
172_K 328_M 1.388 0.85
390_V 418_R 1.387 0.85
200_H 204_E 1.387 0.85
367_V 417_P 1.374 0.85
63_D 115_F 1.365 0.84
310_D 314_R 1.351 0.83
206_D 210_A 1.324 0.82
217_Q 298_A 1.321 0.81
345_V 399_A 1.309 0.80
67_I 71_A 1.308 0.80
67_I 113_M 1.3 0.80
301_D 312_Y 1.289 0.79
9_K 76_A 1.287 0.79
421_L 425_I 1.287 0.79
292_I 400_S 1.286 0.79
348_S 373_M 1.284 0.79
221_D 225_N 1.282 0.79
334_G 337_V 1.277 0.78
362_P 365_V 1.275 0.78
200_H 208_Y 1.269 0.78
398_I 405_N 1.262 0.77
86_F 90_V 1.255 0.76
58_K 63_D 1.242 0.75
318_A 356_E 1.238 0.75
203_K 207_E 1.236 0.75
54_S 117_N 1.231 0.74
213_W 312_Y 1.23 0.74
26_G 129_I 1.23 0.74
81_D 105_V 1.23 0.74
66_I 127_M 1.227 0.74
367_V 413_R 1.227 0.74
366_C 415_S 1.224 0.74
376_N 379_L 1.221 0.74
399_A 409_M 1.22 0.74
236_V 279_G 1.219 0.73
309_P 313_T 1.207 0.72
74_E 77_T 1.199 0.72
263_W 303_F 1.189 0.71
172_K 176_E 1.185 0.70
427_T 447_L 1.18 0.70
170_P 195_N 1.18 0.70
208_Y 212_V 1.174 0.69
345_V 373_M 1.168 0.69
129_I 142_T 1.168 0.69
193_M 202_K 1.167 0.69
46_A 114_R 1.165 0.69
347_C 376_N 1.163 0.68
27_K 74_E 1.15 0.67
175_T 179_A 1.15 0.67
197_L 201_S 1.149 0.67
88_R 91_E 1.144 0.67
413_R 417_P 1.142 0.66
171_F 321_A 1.139 0.66
71_A 97_L 1.129 0.65
42_V 138_V 1.121 0.64
39_L 98_L 1.119 0.64
189_S 318_A 1.117 0.64
5_F 208_Y 1.114 0.64
331_S 432_G 1.112 0.63
224_M 244_R 1.111 0.63
146_I 220_I 1.105 0.63
2_I 328_M 1.097 0.62
81_D 222_R 1.097 0.62
141_K 153_D 1.095 0.62
13_G 18_H 1.093 0.61
94_E 109_R 1.093 0.61
213_W 217_Q 1.092 0.61
87_I 91_E 1.088 0.61
10_V 215_T 1.085 0.60
229_V 233_P 1.079 0.60
347_C 399_A 1.078 0.60
119_N 124_E 1.078 0.60
97_L 104_E 1.075 0.59
29_F 131_A 1.075 0.59
14_P 18_H 1.075 0.59
173_S 176_E 1.075 0.59
13_G 17_S 1.073 0.59
250_S 412_R 1.071 0.59
331_S 334_G 1.057 0.57
188_L 318_A 1.053 0.57
58_K 437_A 1.053 0.57
141_K 155_E 1.052 0.57
30_V 98_L 1.049 0.57
267_F 302_H 1.049 0.57
86_F 89_D 1.043 0.56
401_V 405_N 1.042 0.56
256_D 348_S 1.039 0.56
120_L 142_T 1.038 0.55
372_G 376_N 1.038 0.55
73_N 86_F 1.034 0.55
13_G 16_S 1.034 0.55
337_V 432_G 1.032 0.55
40_D 103_H 1.025 0.54
206_D 310_D 1.024 0.54
58_K 115_F 1.023 0.54
89_D 92_E 1.016 0.53
211_H 215_T 1.015 0.53
54_S 62_T 1.014 0.53
345_V 372_G 1.013 0.53
298_A 302_H 1.012 0.53
247_L 263_W 1.01 0.52
87_I 95_R 1.009 0.52
211_H 214_Q 1.008 0.52
41_S 138_V 1.007 0.52
329_N 334_G 1.006 0.52
217_Q 220_I 1.001 0.51
311_I 357_L 1 0.51
429_Y 433_K 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iafA10.32821000.724Contact Map0.86
1ygyA20.440598.90.936Contact Map0.445
1vs1A40.1528.40.986Contact Map0.682
3tsoC20.15866.70.987Contact Map0.505
3tmlA40.18945.80.987Contact Map0.404
1wotA10.21155.10.988Contact Map0.228
2nptA20.213750.988Contact Map0.38
2hp0A10.38994.60.988Contact Map0.139
2gzdC20.215940.988Contact Map0.279
4c4pB10.215940.988Contact Map0.331
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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