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RIHA - Pyrimidine-specific ribonucleoside hydrolase RihA
UniProt: P41409 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12701
Length: 311 (310)
Sequences: 1832
Seq/Len: 5.91
RIHA
Paralog alert: 0.64 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: RIHA RIHB RIHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_C 110_K 3.998 1.00
106_E 136_S 3.637 1.00
4_P 29_D 2.867 1.00
167_I 274_T 2.844 1.00
32_A 107_L 2.654 1.00
22_A 245_I 2.62 1.00
175_E 179_Q 2.559 1.00
122_V 245_I 2.515 1.00
194_K 293_D 2.492 1.00
135_N 176_I 2.489 1.00
134_L 141_H 2.4 1.00
109_A 133_L 2.396 1.00
175_E 262_G 2.311 1.00
35_S 46_L 2.288 1.00
255_T 293_D 2.286 1.00
123_S 149_I 2.266 1.00
107_L 111_T 2.253 1.00
250_K 298_G 2.245 1.00
192_T 240_H 2.211 1.00
7_L 124_T 2.205 1.00
11_P 49_V 2.178 1.00
67_A 132_L 2.126 1.00
31_K 119_V 2.126 1.00
133_L 137_H 2.117 1.00
3_L 146_R 2.109 1.00
19_I 33_I 2.092 1.00
109_A 137_H 2.076 1.00
8_D 129_N 2.041 1.00
110_K 114_E 1.984 1.00
113_R 137_H 1.949 1.00
23_L 30_V 1.939 1.00
109_A 140_L 1.921 1.00
123_S 130_V 1.912 1.00
112_L 119_V 1.912 1.00
25_S 306_R 1.909 1.00
6_L 34_T 1.869 1.00
4_P 31_K 1.853 1.00
113_R 139_E 1.836 1.00
9_C 124_T 1.834 1.00
264_E 270_T 1.824 1.00
34_T 104_A 1.814 1.00
50_L 98_A 1.789 1.00
239_L 242_P 1.785 1.00
113_R 143_K 1.773 1.00
167_I 174_A 1.77 1.00
20_V 56_L 1.768 1.00
50_L 63_V 1.715 1.00
253_L 298_G 1.689 1.00
5_I 122_V 1.675 1.00
120_T 148_V 1.671 1.00
258_E 289_T 1.669 1.00
118_P 145_A 1.659 1.00
172_E 271_Q 1.648 1.00
297_Q 301_D 1.647 1.00
127_Q 177_V 1.644 1.00
127_Q 149_I 1.636 1.00
64_A 107_L 1.633 1.00
53_L 61_I 1.625 1.00
73_R 271_Q 1.596 0.99
137_H 140_L 1.59 0.99
204_R 301_D 1.57 0.99
7_L 30_V 1.569 0.99
64_A 100_Q 1.569 0.99
23_L 58_R 1.567 0.99
256_S 291_M 1.555 0.99
162_A 273_M 1.552 0.99
206_R 217_A 1.549 0.99
112_L 133_L 1.532 0.99
267_G 270_T 1.49 0.99
295_D 298_G 1.49 0.99
133_L 140_L 1.485 0.99
146_R 185_V 1.479 0.99
54_T 95_P 1.471 0.99
106_E 110_K 1.461 0.99
149_I 178_F 1.452 0.99
42_P 65_G 1.445 0.99
130_V 147_I 1.429 0.98
108_M 130_V 1.378 0.98
120_T 146_R 1.37 0.98
115_S 118_P 1.37 0.98
262_G 269_Y 1.363 0.98
123_S 127_Q 1.349 0.98
264_E 269_Y 1.345 0.97
270_T 275_V 1.339 0.97
108_M 133_L 1.337 0.97
123_S 147_I 1.334 0.97
151_G 167_I 1.329 0.97
214_T 218_E 1.329 0.97
55_L 215_I 1.327 0.97
167_I 178_F 1.324 0.97
149_I 167_I 1.315 0.97
246_A 299_F 1.31 0.97
9_C 49_V 1.289 0.96
105_V 133_L 1.286 0.96
3_L 145_A 1.281 0.96
27_E 306_R 1.273 0.96
149_I 186_M 1.252 0.96
35_S 49_V 1.251 0.96
243_C 294_V 1.237 0.95
30_V 124_T 1.229 0.95
243_C 254_F 1.226 0.95
47_R 51_R 1.222 0.95
247_W 254_F 1.216 0.95
134_L 180_S 1.215 0.95
116_A 143_K 1.213 0.95
187_A 291_M 1.211 0.95
111_T 114_E 1.211 0.95
6_L 32_A 1.208 0.94
112_L 143_K 1.207 0.94
178_F 186_M 1.207 0.94
264_E 267_G 1.202 0.94
108_M 140_L 1.186 0.94
83_G 86_G 1.185 0.94
42_P 46_L 1.181 0.94
6_L 107_L 1.173 0.93
134_L 144_I 1.161 0.93
47_R 94_E 1.149 0.92
105_V 109_A 1.135 0.92
34_T 129_N 1.132 0.92
142_S 145_A 1.131 0.91
54_T 97_F 1.127 0.91
264_E 268_K 1.126 0.91
160_T 163_A 1.125 0.91
263_V 274_T 1.117 0.91
21_L 302_L 1.109 0.90
175_E 265_T 1.105 0.90
201_D 300_V 1.095 0.90
270_T 273_M 1.094 0.90
53_L 58_R 1.093 0.90
103_T 136_S 1.092 0.89
261_V 288_A 1.08 0.89
112_L 140_L 1.077 0.89
103_T 106_E 1.074 0.88
259_R 276_V 1.074 0.88
189_L 240_H 1.072 0.88
185_V 247_W 1.071 0.88
12_G 16_A 1.071 0.88
157_G 163_A 1.065 0.88
53_L 63_V 1.054 0.87
31_K 111_T 1.041 0.86
22_A 122_V 1.04 0.86
10_D 14_D 1.038 0.86
71_L 131_A 1.037 0.86
13_H 88_D 1.03 0.85
64_A 102_C 1.027 0.85
146_R 183_P 1.022 0.85
203_E 207_A 1.022 0.85
7_L 22_A 1.02 0.85
3_L 120_T 1.019 0.85
148_V 247_W 1.007 0.84
158_N 163_A 1.006 0.84
121_I 130_V 1.003 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1yoeA10.99681000.019Contact Map0.819
1q8fA40.99361000.022Contact Map0.842
2masA40.99361000.023Contact Map0.831
4kpoA20.99041000.032Contact Map0.798
4kpnA80.99041000.033Contact Map0.822
3t8jA10.98391000.04Contact Map0.736
3t8iA40.97751000.057Contact Map0.822
3fz0A40.99361000.063Contact Map0.764
4i71A10.97431000.113Contact Map0.718
3epwA20.97431000.116Contact Map0.721
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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