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OPENSEQ.org
YJHU - Uncharacterized transcriptional regulator YjhU
UniProt: P39356 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12604
Length: 328 (308)
Sequences: 954
Seq/Len: 3.10
YJHU
Paralog alert: 0.41 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: LSRR YJHU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
258_D 262_M 5.683 1.00
211_T 279_Q 3.306 1.00
106_L 291_G 3.224 1.00
125_G 213_C 2.906 1.00
299_T 317_T 2.777 1.00
79_F 303_L 2.647 1.00
122_D 214_T 2.645 1.00
79_F 300_L 2.469 1.00
257_Y 301_G 2.39 1.00
288_F 308_V 2.334 1.00
220_V 288_F 2.324 1.00
290_A 299_T 2.289 1.00
219_V 288_F 2.24 1.00
58_H 62_D 2.234 1.00
149_V 175_L 2.194 1.00
313_V 317_T 2.105 1.00
136_S 167_S 2.096 1.00
113_Y 312_I 2.076 1.00
300_L 304_L 2.021 1.00
151_Q 165_I 1.992 1.00
300_L 321_L 1.992 1.00
250_G 301_G 1.954 1.00
28_K 36_I 1.877 0.99
50_T 54_N 1.869 0.99
241_Q 245_D 1.846 0.99
135_M 289_L 1.841 0.99
194_A 198_Q 1.825 0.99
73_L 76_R 1.733 0.99
210_L 213_C 1.722 0.99
218_F 288_F 1.706 0.99
75_I 84_V 1.69 0.98
125_G 152_M 1.68 0.98
296_Y 317_T 1.676 0.98
259_K 297_D 1.674 0.98
250_G 257_Y 1.668 0.98
88_P 315_E 1.661 0.98
188_V 193_L 1.66 0.98
82_Q 285_R 1.656 0.98
214_T 284_E 1.654 0.98
286_K 309_T 1.653 0.98
49_Q 53_E 1.577 0.97
113_Y 310_D 1.552 0.97
110_G 289_L 1.549 0.97
220_V 308_V 1.532 0.97
127_A 253_C 1.531 0.96
24_Y 59_I 1.531 0.96
23_Y 41_R 1.511 0.96
121_G 146_N 1.508 0.96
216_A 280_L 1.495 0.96
276_S 279_Q 1.484 0.96
258_D 264_V 1.484 0.96
42_V 45_V 1.461 0.95
19_A 33_V 1.455 0.95
123_V 209_V 1.454 0.95
204_R 208_D 1.432 0.94
44_V 48_L 1.428 0.94
292_G 314_D 1.416 0.94
74_Q 77_D 1.4 0.93
125_G 128_W 1.397 0.93
296_Y 321_L 1.38 0.93
16_V 56_L 1.377 0.93
257_Y 298_A 1.376 0.93
85_I 109_A 1.375 0.93
213_C 283_I 1.374 0.93
113_Y 117_V 1.364 0.92
216_A 283_I 1.363 0.92
139_M 171_I 1.349 0.92
259_K 301_G 1.338 0.91
124_L 215_K 1.337 0.91
27_G 52_R 1.327 0.91
220_V 298_A 1.319 0.90
107_S 291_G 1.305 0.90
87_V 109_A 1.298 0.90
81_L 309_T 1.295 0.89
285_R 310_D 1.294 0.89
191_A 270_Q 1.288 0.89
76_R 83_R 1.286 0.89
301_G 304_L 1.27 0.88
123_V 214_T 1.263 0.88
320_F 323_A 1.261 0.88
299_T 313_V 1.259 0.88
302_A 305_G 1.255 0.87
197_L 273_L 1.247 0.87
188_V 197_L 1.245 0.87
22_L 30_Q 1.241 0.86
83_R 310_D 1.241 0.86
296_Y 320_F 1.232 0.86
266_A 269_D 1.223 0.85
250_G 302_A 1.223 0.85
155_S 251_V 1.222 0.85
128_W 251_V 1.194 0.83
157_P 163_T 1.182 0.83
16_V 19_A 1.178 0.82
314_D 317_T 1.177 0.82
151_Q 163_T 1.163 0.81
107_S 134_Q 1.162 0.81
127_A 151_Q 1.154 0.81
219_V 299_T 1.147 0.80
191_A 195_M 1.145 0.80
123_V 213_C 1.143 0.80
151_Q 183_H 1.142 0.80
186_A 256_F 1.129 0.78
219_V 290_A 1.124 0.78
78_K 321_L 1.123 0.78
255_R 274_G 1.12 0.78
148_T 180_A 1.119 0.78
20_T 48_L 1.116 0.77
265_V 269_D 1.114 0.77
29_S 41_R 1.113 0.77
189_S 201_P 1.113 0.77
118_I 124_L 1.102 0.76
260_E 304_L 1.096 0.76
218_F 308_V 1.093 0.75
75_I 86_I 1.092 0.75
207_F 210_L 1.092 0.75
215_K 287_I 1.088 0.75
21_W 25_Q 1.081 0.74
124_L 149_V 1.071 0.73
70_D 74_Q 1.069 0.73
127_A 255_R 1.063 0.72
180_A 209_V 1.056 0.72
233_G 247_G 1.054 0.71
241_Q 244_R 1.05 0.71
128_W 255_R 1.05 0.71
75_I 79_F 1.05 0.71
75_I 120_N 1.036 0.70
79_F 210_L 1.032 0.69
239_E 271_R 1.032 0.69
106_L 110_G 1.031 0.69
189_S 200_E 1.02 0.68
23_Y 45_V 1.016 0.67
123_V 212_R 1.015 0.67
48_L 251_V 1.014 0.67
88_P 129_G 1.01 0.67
174_K 289_L 1.01 0.67
257_Y 278_A 1.008 0.67
118_I 147_V 1.005 0.66
200_E 254_G 1.005 0.66
242_T 246_L 1.005 0.66
34_A 44_V 1.001 0.66
117_V 215_K 1.001 0.66
200_E 229_L 1.001 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2w48A40.95121000.405Contact Map0.758
4go1A20.95431000.409Contact Map0.717
4l5jA40.94211000.412Contact Map0.753
4l4yA20.79881000.475Contact Map0.75
3efbA40.80181000.477Contact Map0.774
2r5fA10.79271000.493Contact Map0.754
2o0mA10.95431000.495Contact Map0.681
3kv1A10.80181000.496Contact Map0.704
2gnpA10.80791000.498Contact Map0.736
3nzeA20.80181000.503Contact Map0.697
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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