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OPENSEQ.org
LSRR - Transcriptional regulator LsrR
UniProt: P76141 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13805
Length: 317 (298)
Sequences: 962
Seq/Len: 3.23
LSRR
Paralog alert: 0.41 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: LSRR YJHU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
250_D 254_D 5.749 1.00
201_Q 272_A 3.42 1.00
121_A 203_A 2.911 1.00
292_I 310_T 2.881 1.00
118_Q 204_D 2.656 1.00
82_F 296_M 2.615 1.00
82_F 293_A 2.612 1.00
249_F 294_A 2.364 1.00
210_I 281_G 2.316 1.00
283_A 292_I 2.308 1.00
209_G 281_G 2.25 1.00
281_G 301_I 2.224 1.00
61_R 65_N 2.22 1.00
148_T 161_G 2.14 1.00
306_T 310_T 2.093 1.00
293_A 314_I 2.082 1.00
109_M 305_V 2.042 1.00
102_L 284_G 2.011 1.00
293_A 297_K 1.978 1.00
242_G 294_A 1.897 0.99
133_Q 163_L 1.896 0.99
31_L 39_R 1.877 0.99
78_L 87_V 1.869 0.99
132_L 282_V 1.845 0.99
53_K 57_S 1.824 0.99
233_L 237_R 1.782 0.99
289_A 310_T 1.758 0.99
76_T 79_R 1.743 0.99
184_A 188_K 1.741 0.99
208_V 281_G 1.724 0.99
121_A 149_L 1.714 0.99
251_A 290_E 1.711 0.99
91_P 308_Q 1.705 0.99
279_R 302_N 1.694 0.99
204_D 277_P 1.686 0.99
200_A 203_A 1.684 0.98
27_Y 62_V 1.681 0.98
85_Q 278_V 1.674 0.98
242_G 249_F 1.673 0.98
103_G 284_G 1.604 0.98
178_A 183_I 1.603 0.98
52_E 56_Q 1.593 0.98
77_Q 80_R 1.591 0.98
109_M 303_A 1.588 0.98
123_G 245_L 1.58 0.97
106_A 282_V 1.557 0.97
181_A 185_R 1.544 0.97
250_D 256_V 1.516 0.97
22_I 36_I 1.487 0.96
206_A 273_L 1.466 0.96
119_M 199_A 1.461 0.95
194_K 198_L 1.444 0.95
121_A 124_F 1.443 0.95
210_I 301_I 1.436 0.95
45_L 48_S 1.429 0.95
26_Y 44_R 1.399 0.94
269_P 272_A 1.399 0.94
136_S 167_C 1.397 0.94
251_A 294_A 1.397 0.94
285_G 307_D 1.387 0.94
120_L 205_V 1.375 0.93
292_I 306_T 1.364 0.93
25_F 33_Q 1.362 0.93
249_F 291_A 1.355 0.92
32_T 44_R 1.353 0.92
47_V 51_L 1.351 0.92
278_V 303_A 1.348 0.92
109_M 113_L 1.345 0.92
79_R 86_H 1.342 0.92
100_G 103_G 1.34 0.92
289_A 314_I 1.313 0.91
203_A 276_I 1.31 0.91
206_A 276_I 1.308 0.91
30_G 55_H 1.299 0.90
295_A 298_G 1.293 0.90
19_V 59_I 1.283 0.89
117_Q 143_Q 1.277 0.89
289_A 313_A 1.275 0.89
210_I 291_A 1.27 0.89
179_S 191_N 1.259 0.88
86_H 303_A 1.257 0.88
294_A 297_K 1.245 0.88
242_G 295_A 1.244 0.87
313_A 316_R 1.242 0.87
119_M 204_D 1.24 0.87
84_L 302_N 1.238 0.87
187_L 266_I 1.234 0.87
114_L 120_L 1.223 0.86
119_M 203_A 1.205 0.85
152_G 243_D 1.201 0.85
205_V 280_V 1.201 0.85
123_G 148_T 1.197 0.85
258_N 262_H 1.194 0.84
307_D 310_T 1.194 0.84
120_L 146_L 1.178 0.83
124_F 243_D 1.177 0.83
81_Q 314_I 1.173 0.83
178_A 187_L 1.157 0.82
24_W 28_H 1.148 0.81
148_T 173_P 1.139 0.80
247_Y 267_G 1.136 0.80
23_A 51_L 1.125 0.79
82_F 200_A 1.118 0.79
73_E 77_Q 1.113 0.78
209_G 283_A 1.11 0.78
45_L 66_S 1.106 0.78
176_L 248_F 1.104 0.77
181_A 263_N 1.099 0.77
102_L 105_G 1.094 0.76
209_G 292_I 1.086 0.76
208_V 301_I 1.071 0.74
96_A 250_D 1.066 0.74
197_L 200_A 1.064 0.74
257_T 262_H 1.064 0.74
148_T 159_G 1.06 0.73
124_F 247_Y 1.053 0.73
252_K 297_K 1.051 0.72
284_G 292_I 1.046 0.72
231_E 264_E 1.039 0.71
195_D 198_L 1.038 0.71
51_L 243_D 1.038 0.71
78_L 82_F 1.038 0.71
170_N 282_V 1.038 0.71
25_F 36_I 1.037 0.71
33_Q 45_L 1.034 0.71
78_L 116_P 1.029 0.70
123_G 247_Y 1.025 0.70
249_F 271_S 1.019 0.69
234_M 238_K 1.014 0.68
240_A 256_V 1.01 0.68
95_D 309_D 1.004 0.67
90_I 105_G 1.003 0.67
78_L 89_V 1.002 0.67
24_W 91_P 1 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4go1A20.98741000.367Contact Map0.734
4l5jA40.98741000.368Contact Map0.76
2w48A40.95581000.395Contact Map0.763
4l4yA20.82651000.451Contact Map0.772
3efbA40.80131000.475Contact Map0.773
2o0mA10.96211000.484Contact Map0.697
2r5fA10.78861000.49Contact Map0.772
3kv1A10.79181000.49Contact Map0.705
2gnpA10.79181000.495Contact Map0.754
3nzeA20.79811000.498Contact Map0.701
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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